PMID- 32111301
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 1873-7528 (Electronic)
IS  - 0149-7634 (Linking)
VI  - 110
DP  - 2020 Mar
TI  - Glucose signaling in the brain and periphery to memory.
PG  - 100-113
LID - S0149-7634(18)30365-8 [pii]
LID - 10.1016/j.neubiorev.2019.03.018 [doi]
AB  - Glucose has many diverse physiological roles such as energy metabolism, appetite 
      control and memory consolidation. We recently reported that memory-related gene 
      expression is epigenetically controlled in murine brain cells and that glucose 
      can regulate gene expression in a cell-specific manner. However, the literature 
      reviews have indicated that glucose can also regulate gut cells to release 
      incretins which might play a role in memory processes directly or indirectly by 
      vagus nerve stimulation. In this review, we discussed the effects of glucose on 
      the gut and brain, aiming to understand more in-depth the role of glucose in 
      memory function. In addition, we also discussed the alteration of 
      glucose-signaling in type-2 diabetes mellitus (T2DM) and a possible link to 
      Alzheimer's disease (AD) pathologies.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Hossain, Md Shamim
AU  - Hossain MS
AD  - Department of Neuroinflammation and Brain Fatigue Science, Kyushu University 
      Graduate School of Medical Sciences, Fukuoka, Japan. Electronic address: 
      shamim@physiol.med.kyushu-u.ac.jp.
FAU - Oomura, Yutaka
AU  - Oomura Y
AD  - Department of Neuroinflammation and Brain Fatigue Science, Kyushu University 
      Graduate School of Medical Sciences, Fukuoka, Japan.
FAU - Fujino, Takehiko
AU  - Fujino T
AD  - Institute of Rheological Functions of Food, 2241-1 Kubara, Hisayama-machi, 
      Kasuya-gun, Fukuoka, 811-2501, Japan.
FAU - Akashi, Koichi
AU  - Akashi K
AD  - Department of Medicine and Biosystemic Science, Kyushu University Graduate School 
      of Medical Sciences, Fukuoka, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Neurosci Biobehav Rev
JT  - Neuroscience and biobehavioral reviews
JID - 7806090
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Alzheimer Disease/metabolism/*physiopathology
MH  - Animals
MH  - Brain/*physiology/physiopathology
MH  - Diabetes Mellitus, Type 2/metabolism
MH  - Glucose/*metabolism
MH  - Humans
MH  - Memory/*physiology
MH  - Signal Transduction/physiology
OTO - NOTNLM
OT  - BDNF
OT  - Epigenetics
OT  - FGF-1
OT  - Glucose
OT  - Incretins
OT  - Memory
OT  - Vagus nerve
EDAT- 2020/03/01 06:00
MHDA- 2021/01/12 06:00
CRDT- 2020/03/01 06:00
PHST- 2018/05/20 00:00 [received]
PHST- 2019/01/30 00:00 [revised]
PHST- 2019/03/24 00:00 [accepted]
PHST- 2020/03/01 06:00 [entrez]
PHST- 2020/03/01 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
AID - S0149-7634(18)30365-8 [pii]
AID - 10.1016/j.neubiorev.2019.03.018 [doi]
PST - ppublish
SO  - Neurosci Biobehav Rev. 2020 Mar;110:100-113. doi: 
      10.1016/j.neubiorev.2019.03.018.