PMID- 32112065
OWN - NLM
STAT- MEDLINE
DCOM- 20200903
LR  - 20200903
IS  - 2972-4066 (Electronic)
IS  - 0304-4602 (Linking)
VI  - 48
IP  - 12
DP  - 2019 Dec
TI  - Renal Transplant Outcomes in Spousal and Living-Related Donors in Malaysia.
PG  - 403-411
AB  - INTRODUCTION: Studies have shown that a compatible human leukocyte antigen (HLA) 
      match can confer a favourable effect on graft outcomes. We examined the outcomes 
      of HLA matching in renal transplant donors in Malaysia. MATERIALS AND METHODS: A 
      total of 140 patients who had compatible ABO blood type with negative T-cell 
      lymphocytotoxicity crossmatch were included in the study and 25% of them were 
      spousal transplant donors. No remarkable differences in acute rejection rate, 
      graft survival, patient survival and serum creatinine level were observed between 
      the spousal and living-related donor groups. RESULTS: The spousal donor group had 
      a higher degree of HLA mismatch than the living-related donor group. HLA-A 
      mismatch was associated with increased rejection risk at 6 months (odds ratio 
      [OR], 2.75; P = 0.04), 1 year (OR, 2.54; P = 0.03) and 3 years (OR, 3.69; P = 
      0.001). It was also observed in the deleterious effects of HLA-B and HLA-DQ loci 
      when the number of antigen mismatches increased. The risk was 7 times higher in 
      patients with >/=1 mismatch at HLA-A, HLA-B and HLA-DR loci than those who did not 
      have a mismatch at these loci at 6 months (P = 0.01), 1 year (P = 0.03) and 3 
      years (P = 0.003). CONCLUSION: A good match for HLA-A, HLA-B, HLA-DR and HLA-DQ 
      can prevent acute rejection risk in renal transplant patients. Consequently, 
      spousal donor transplants could be a safe intervention in renal patients.
FAU - Guad, Rhanye Mac
AU  - Guad RM
AD  - Department of Biomedical Science and Therapeutics, Faculty of Medicine and Health 
      Sciences, Universiti Malaysia Sabah, Malaysia.
FAU - Ng, Kok Peng
AU  - Ng KP
FAU - Lim, Soo Kun
AU  - Lim SK
FAU - Hirayama, Kenji
AU  - Hirayama K
FAU - Eng, Hooi Sian
AU  - Eng HS
FAU - Wan Md Adnan, Wan Ahmad Hafiz
AU  - Wan Md Adnan WAH
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Ann Acad Med Singap
JT  - Annals of the Academy of Medicine, Singapore
JID - 7503289
SB  - IM
MH  - Adult
MH  - *Family
MH  - Female
MH  - Graft Rejection/epidemiology
MH  - Graft Survival
MH  - Histocompatibility Testing
MH  - Humans
MH  - Kidney Transplantation/*statistics & numerical data
MH  - Malaysia
MH  - Male
MH  - Spouses/*statistics & numerical data
MH  - Tissue Donors/*statistics & numerical data
MH  - Treatment Outcome
EDAT- 2020/03/01 06:00
MHDA- 2020/09/04 06:00
CRDT- 2020/03/01 06:00
PHST- 2020/03/01 06:00 [entrez]
PHST- 2020/03/01 06:00 [pubmed]
PHST- 2020/09/04 06:00 [medline]
PST - ppublish
SO  - Ann Acad Med Singap. 2019 Dec;48(12):403-411.