PMID- 32112445 OWN - NLM STAT- MEDLINE DCOM- 20210430 LR - 20210430 IS - 1097-0274 (Electronic) IS - 0271-3586 (Linking) VI - 63 IP - 5 DP - 2020 May TI - Occupational exposure to manganese and risk of creatine kinase and creatine kinase-MB elevation among ferromanganese refinery workers. PG - 394-401 LID - 10.1002/ajim.23097 [doi] AB - BACKGROUND: Elevated exposure to manganese (Mn) could induce cardiovascular dysfunction. However, limited research is available on the effects of occupational Mn exposure on myocardial enzymes. We aimed to evaluate the relationships between Mn exposure and myocardial enzyme elevation among Mn-exposed workers. METHODS: Data were from a follow-up investigation of a Mn-exposed workers healthy cohort in 2017. A total of 744 workers were divided into low-exposure and high-exposure groups according to Mn time-weighted average (Mn-TWA) of less than or equal to 0.15 mg/m(3) or greater than 0.15 mg/m(3) , respectively. Serum levels of myocardial enzymes, including creatine kinase (CK) and creatine kinase-MB (CK-MB), lactic dehydrogenase, alpha-hydroxybutyrate dehydrogenase, and aspartate transaminase, were assessed, as well as airborne Mn exposure levels. RESULTS: After adjustment for sex, body mass index, seniority, education, current smoking status, current drinking status, and hypertension, Mn-TWA levels were positively associated with the risk of CK elevation (odds ratio [OR] = 1.47 (95% confidence interval [CI]: 1.18-1.83) per interquartile range [IQR] increase), and risk of CK-MB elevation [OR = 1.57 (95% CI: 1.03-2.38) per IQR increase]. In a stratified analysis, Mn-TWA levels were positively correlated with CK elevation in workers of seniority greater than 19 years, male workers, current smokers, and drinkers. CONCLUSION: Our results suggest that occupational exposure to Mn is associated with increased risk of CK and CK-MB elevation. The potential mechanisms of the associations between airborne exposure to Mn and increased risk of these myocardial enzyme elevations warrant further investigation. CI - (c) 2020 Wiley Periodicals, Inc. FAU - Huang, Sifang AU - Huang S AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. FAU - Liu, Zhenfang AU - Liu Z AD - Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. FAU - Ge, Xiaoting AU - Ge X AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. FAU - Luo, Xiaoyu AU - Luo X AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. FAU - Zhou, Yanting AU - Zhou Y AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. FAU - Li, Defu AU - Li D AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. FAU - Li, Longman AU - Li L AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. FAU - Chen, Xiang AU - Chen X AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. FAU - Huang, Lulu AU - Huang L AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. FAU - Cheng, Hong AU - Cheng H AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. FAU - Hou, Qingzhi AU - Hou Q AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. FAU - Zan, Gaohui AU - Zan G AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. FAU - Tan, Yanli AU - Tan Y AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. FAU - Liu, Chaoqun AU - Liu C AD - Department of Nutrition and Food Hygiene, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. FAU - Zou, Yunfeng AU - Zou Y AD - Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, Guangxi, China. FAU - Yang, Xiaobo AU - Yang X AUID- ORCID: 0000-0001-9866-7724 AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. AD - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, Guangxi, China. AD - Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200229 PL - United States TA - Am J Ind Med JT - American journal of industrial medicine JID - 8101110 RN - 0 (Air Pollutants, Occupational) RN - 0 (Biomarkers) RN - 0 (ferro-manganese alloy) RN - 42Z2K6ZL8P (Manganese) RN - E1UOL152H7 (Iron) RN - EC 2.7.3.2 (Creatine Kinase) RN - EC 2.7.3.2 (Creatine Kinase, MB Form) SB - IM MH - Adult MH - Air Pollutants, Occupational/*adverse effects/analysis MH - Biomarkers/blood MH - Creatine Kinase/*blood MH - Creatine Kinase, MB Form/*blood MH - Female MH - Follow-Up Studies MH - Humans MH - Iron MH - Male MH - Manganese/*adverse effects/analysis MH - *Metallurgy MH - Middle Aged MH - Occupational Exposure/*adverse effects/analysis MH - Odds Ratio MH - Risk Factors OTO - NOTNLM OT - creatine kinase OT - creatine kinase-MB OT - manganese OT - myocardial enzyme OT - occupation EDAT- 2020/03/01 06:00 MHDA- 2021/05/01 06:00 CRDT- 2020/03/01 06:00 PHST- 2019/10/05 00:00 [received] PHST- 2020/02/13 00:00 [revised] PHST- 2020/02/14 00:00 [accepted] PHST- 2020/03/01 06:00 [pubmed] PHST- 2021/05/01 06:00 [medline] PHST- 2020/03/01 06:00 [entrez] AID - 10.1002/ajim.23097 [doi] PST - ppublish SO - Am J Ind Med. 2020 May;63(5):394-401. doi: 10.1002/ajim.23097. Epub 2020 Feb 29.