PMID- 32112506 OWN - NLM STAT- MEDLINE DCOM- 20211108 LR - 20211108 IS - 1097-0193 (Electronic) IS - 1065-9471 (Print) IS - 1065-9471 (Linking) VI - 41 IP - 8 DP - 2020 Jun 1 TI - Parietal memory network and default mode network in first-episode drug-naive schizophrenia: Associations with auditory hallucination. PG - 1973-1984 LID - 10.1002/hbm.24923 [doi] AB - Atypical spontaneous activities in resting-state networks may play a role in auditory hallucinations (AHs), but networks relevant to AHs are not apparent. Given the debating role of the default mode network (DMN) in AHs, a parietal memory network (PMN) may better echo cognitive theories of AHs in schizophrenia, because PMN is spatially adjacent to the DMN and more relevant to memory processing or information integration. To examine whether PMN is more relevant to AHs than DMN, we characterized these intrinsic networks in AHs with 59 first-episode, drug-naive schizophrenics (26 AH+ and 33 AH-) and 60 healthy participants in resting-state fMRI. We separated the PMN, DMN, and auditory network (AN) using independent component analysis, and compared their functional connectivity across the three groups. We found that only AH+ patients displayed dysconnectivity in PMN, both AH+ and AH- patients exhibited dysfunctions of AN, but neither patient group showed abnormal connectivity within DMN. The connectivity of PMN significantly correlated with memory performance of the patients. Further region-of-interest analyses confirmed that the connectivity between the core regions of PMN, the left posterior cingulate gyrus and the left precuneus, was significantly lower only in the AH+ group. In exploratory correlation analysis, this functional connectivity metric significantly correlated with the severity of AH symptoms. The results implicate that compared to the DMN, the PMN is more relevant to the AH symptoms in schizophrenia, and further provides a more precise potential brain modulation target for the intervention of AH symptoms. CI - (c) 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. FAU - Guo, Qian AU - Guo Q AUID- ORCID: 0000-0001-5199-6942 AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China. AD - Department of Early Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Hu, Yang AU - Hu Y AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China. FAU - Zeng, Botao AU - Zeng B AD - Department of Psychiatry, Qingdao Mental Health Center, Qingdao, China. FAU - Tang, Yingying AU - Tang Y AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Li, Guanjun AU - Li G AD - Department of Early Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhang, Tianhong AU - Zhang T AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wang, Jinhong AU - Wang J AD - Department of Medical Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Northoff, Georg AU - Northoff G AD - University of Ottawa Brain and Mind Research Institute, and Mind Brain Imaging and Neuroethics Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada. FAU - Li, Chunbo AU - Li C AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China. AD - Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Bio-X Institutes, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China. AD - Institute of Psychology and Behaviour Science, Shanghai Jiao Tong University, Shanghai, China. FAU - Goff, Donald AU - Goff D AD - Department of Psychiatry, New York University School of Medicine, New York, New York. FAU - Wang, Jijun AU - Wang J AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China. AD - Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Bio-X Institutes, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China. AD - Institute of Psychology and Behaviour Science, Shanghai Jiao Tong University, Shanghai, China. FAU - Yang, Zhi AU - Yang Z AUID- ORCID: 0000-0002-2222-2312 AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China. AD - Institute of Psychology and Behaviour Science, Shanghai Jiao Tong University, Shanghai, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200229 PL - United States TA - Hum Brain Mapp JT - Human brain mapping JID - 9419065 SB - IM MH - Adolescent MH - Adult MH - *Connectome MH - Default Mode Network/diagnostic imaging/*physiopathology MH - Female MH - Hallucinations/diagnostic imaging/etiology/*physiopathology MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Memory MH - Nerve Net/diagnostic imaging/*physiopathology MH - Schizophrenia/complications/diagnostic imaging/*physiopathology MH - Young Adult PMC - PMC7267906 OTO - NOTNLM OT - auditory hallucination OT - default mode network OT - functional connectivity OT - parietal memory network COIS- The authors report no biomedical financial interests or potential conflicts of interest. EDAT- 2020/03/01 06:00 MHDA- 2021/11/09 06:00 PMCR- 2020/02/29 CRDT- 2020/03/01 06:00 PHST- 2019/08/16 00:00 [received] PHST- 2019/11/29 00:00 [revised] PHST- 2020/01/01 00:00 [accepted] PHST- 2020/03/01 06:00 [pubmed] PHST- 2021/11/09 06:00 [medline] PHST- 2020/03/01 06:00 [entrez] PHST- 2020/02/29 00:00 [pmc-release] AID - HBM24923 [pii] AID - 10.1002/hbm.24923 [doi] PST - ppublish SO - Hum Brain Mapp. 2020 Jun 1;41(8):1973-1984. doi: 10.1002/hbm.24923. Epub 2020 Feb 29.