PMID- 32112839
OWN - NLM
STAT- MEDLINE
DCOM- 20210203
LR  - 20210203
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 152
DP  - 2020 Jun 1
TI  - Fabrication of bioinspired chitosan/gelatin/allantoin biocomposite film for wound 
      dressing application.
PG  - 873-883
LID - S0141-8130(19)40291-2 [pii]
LID - 10.1016/j.ijbiomac.2020.02.289 [doi]
AB  - A biocomposite film composed of biopolymers chitosan (CS), gelatin (GE) and 
      allantoin (AT) was fabricated by solution casting technique. The functional group 
      interaction of the biocomposite films was inspected through the Attenuated total 
      reflectance Fourier transform spectrometer (ATR-FTIR). The morphological changes 
      and crystallinity of biocomposite films with varied ratios of chitosan/gelatin 
      (CS/GE) and allantoin were examined under Scanning electron microscope (SEM) and 
      X-ray diffractometer (XRD). The water-absorbing capacity was found enhanced by an 
      increase in the chitosan ratio. The biocomposite films exhibit good antioxidant, 
      anti-inflammatory properties. The biocomposite films also display enhanced 
      stability with steady degradation under the PBS medium. The biocomposite films 
      reveal improved antibacterial activity against Escherichia coli (E.coli) and 
      Staphylococcus aureus (S.aureus). Blood compatibility studies explore the 
      non-hemolytic nature. The in vitro cytotoxicity by MTT assay shows excellent 
      biocompatibility. The fibroblast adhesion on the biocomposite film displays 
      enhanced proliferation and viability. These significant biological properties of 
      biocomposite film make it an appropriate candidate for wound dressing 
      application.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Sakthiguru, Nagarajan
AU  - Sakthiguru N
AD  - PG and Research Department of Chemistry, Islamiah College (Autonomous), 
      Vaniyambadi 635 752, Tamil Nadu, India.
FAU - Sithique, Mohamed Aboobucker
AU  - Sithique MA
AD  - PG and Research Department of Chemistry, Islamiah College (Autonomous), 
      Vaniyambadi 635 752, Tamil Nadu, India. Electronic address: masithique@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20200226
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Free Radical Scavengers)
RN  - 344S277G0Z (Allantoin)
RN  - 9000-70-8 (Gelatin)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Allantoin/*chemistry
MH  - Animals
MH  - Anti-Bacterial Agents/chemistry/pharmacology
MH  - Anti-Inflammatory Agents/chemistry/pharmacology
MH  - *Bandages
MH  - Biocompatible Materials/*chemistry/*pharmacology
MH  - Cell Adhesion/drug effects
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Chitosan/*chemistry
MH  - Free Radical Scavengers/chemistry/pharmacology
MH  - Gelatin/*chemistry
MH  - Materials Testing
MH  - Mechanical Phenomena
MH  - Mice
MH  - Wound Healing/*drug effects
OTO - NOTNLM
OT  - Allantoin
OT  - Antibacterial
OT  - Biocompatibility
OT  - Blood compatible
OT  - Cell adhesion
OT  - Chitosan
OT  - Gelatin
EDAT- 2020/03/01 06:00
MHDA- 2021/02/04 06:00
CRDT- 2020/03/01 06:00
PHST- 2019/12/13 00:00 [received]
PHST- 2020/02/21 00:00 [revised]
PHST- 2020/02/25 00:00 [accepted]
PHST- 2020/03/01 06:00 [pubmed]
PHST- 2021/02/04 06:00 [medline]
PHST- 2020/03/01 06:00 [entrez]
AID - S0141-8130(19)40291-2 [pii]
AID - 10.1016/j.ijbiomac.2020.02.289 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2020 Jun 1;152:873-883. doi: 10.1016/j.ijbiomac.2020.02.289. 
      Epub 2020 Feb 26.