PMID- 32114182
OWN - NLM
STAT- MEDLINE
DCOM- 20200413
LR  - 20200413
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 120
DP  - 2020 Apr
TI  - The ontogenetic path of human dendritic cells.
PG  - 122-129
LID - S0161-5890(19)30925-3 [pii]
LID - 10.1016/j.molimm.2020.02.010 [doi]
AB  - Dendritic cells (DCs) orchestrate adaptive immune responses. In healthy 
      individuals, DCs are drivers and fine-tuners of T cell responses directed against 
      invading pathogens or cancer cells. In parallel, DCs control autoreactive T 
      cells, thereby maintaining T cell tolerance. Under various disease conditions, a 
      disruption of this delicate balance can lead to chronic infections, tumor 
      evasion, or autoimmunity. While great efforts have been made to unravel the 
      origin and development of this powerful cell type in mice, only little is known 
      about the ontogeny of human DCs. Here, we summarize the current understanding of 
      the developmental path of DCs from hematopoietic stem cells to fully functional 
      DCs in their local tissue environment and provide a template for the 
      identification of DCs across various tissues.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Amon, Lukas
AU  - Amon L
AD  - Laboratory of Dendritic Cell Biology, Department of Dermatology, University 
      Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nurnberg, 
      Hartmannstrasse 14, D-91052 Erlangen, Germany.
FAU - Lehmann, Christian H K
AU  - Lehmann CHK
AD  - Laboratory of Dendritic Cell Biology, Department of Dermatology, University 
      Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nurnberg, 
      Hartmannstrasse 14, D-91052 Erlangen, Germany; Medical Immunology Campus Erlangen, 
      D-91054 Erlangen, Germany.
FAU - Heger, Lukas
AU  - Heger L
AD  - Laboratory of Dendritic Cell Biology, Department of Dermatology, University 
      Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nurnberg, 
      Hartmannstrasse 14, D-91052 Erlangen, Germany.
FAU - Heidkamp, Gordon F
AU  - Heidkamp GF
AD  - Laboratory of Dendritic Cell Biology, Department of Dermatology, University 
      Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nurnberg, 
      Hartmannstrasse 14, D-91052 Erlangen, Germany; Roche Innovation Center Munich, 
      Roche Pharmaceutical Research and Early Development, pRED, Munich, Germany.
FAU - Dudziak, Diana
AU  - Dudziak D
AD  - Laboratory of Dendritic Cell Biology, Department of Dermatology, University 
      Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nurnberg, 
      Hartmannstrasse 14, D-91052 Erlangen, Germany; Medical Immunology Campus Erlangen, 
      D-91054 Erlangen, Germany. Electronic address: diana.dudziak@uk-erlangen.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200228
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
SB  - IM
MH  - Animals
MH  - Autoimmunity
MH  - Cell Differentiation/immunology
MH  - Cellular Microenvironment/immunology
MH  - Dendritic Cells/classification/*cytology/*immunology
MH  - Hematopoietic Stem Cells/classification/cytology/immunology
MH  - Humans
MH  - Immune Tolerance
MH  - Mice
MH  - Models, Immunological
MH  - Organ Specificity
MH  - Phenotype
OTO - NOTNLM
OT  - Conventional
OT  - DC
OT  - Human
OT  - Ontogeny
OT  - Progeny
OT  - Transcription factor
EDAT- 2020/03/03 06:00
MHDA- 2020/04/14 06:00
CRDT- 2020/03/02 06:00
PHST- 2019/12/24 00:00 [received]
PHST- 2020/02/15 00:00 [accepted]
PHST- 2020/03/03 06:00 [pubmed]
PHST- 2020/04/14 06:00 [medline]
PHST- 2020/03/02 06:00 [entrez]
AID - S0161-5890(19)30925-3 [pii]
AID - 10.1016/j.molimm.2020.02.010 [doi]
PST - ppublish
SO  - Mol Immunol. 2020 Apr;120:122-129. doi: 10.1016/j.molimm.2020.02.010. Epub 2020 
      Feb 28.