PMID- 32114592
OWN - NLM
STAT- MEDLINE
DCOM- 20201230
LR  - 20240404
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Print)
IS  - 0007-0920 (Linking)
VI  - 122
IP  - 8
DP  - 2020 Apr
TI  - Omega-3, omega-6 and total dietary polyunsaturated fat on cancer incidence: 
      systematic review and meta-analysis of randomised trials.
PG  - 1260-1270
LID - 10.1038/s41416-020-0761-6 [doi]
AB  - BACKGROUND: The relationship between long-chain omega-3 (LCn3), alpha-linolenic 
      acid (ALA), omega-6 and total polyunsaturated fatty acid (PUFA) intakes and 
      cancer risk is unclear. METHODS: We searched Medline, Embase, CENTRAL and trials 
      registries for RCTs comparing higher with lower LCn3, ALA, omega-6 and/or total 
      PUFA, that assessed cancers over >/=12 months. Random-effects meta-analyses, 
      sensitivity analyses, subgrouping, risk of bias and GRADE were used. RESULTS: We 
      included 47 RCTs (108,194 participants). Increasing LCn3 has little or no effect 
      on cancer diagnosis (RR1.02, 95% CI 0.98-1.07), cancer death (RR0.97, 95% CI 
      0.90-1.06) or breast cancer diagnosis (RR1.03, 95% CI 0.89-1.20); increasing ALA 
      has little or no effect on cancer death (all high/moderate-quality evidence). 
      Increasing LCn3 (NNTH 334, RR1.10, 95% CI 0.97-1.24) and ALA (NNTH 334, RR1.30, 
      95% CI 0.72-2.32) may slightly increase prostate cancer risk; increasing total 
      PUFA may slightly increase risk of cancer diagnosis (NNTH 125, RR1.19, 95% CI 
      0.99-1.42) and cancer death (NNTH 500, RR1.10, 95% CI 0.48-2.49) but total PUFA 
      doses were very high in some trials. CONCLUSIONS: The most extensive systematic 
      review to assess the effects of increasing PUFAs on cancer risk found increasing 
      total PUFA may very slightly increase cancer risk, offset by small protective 
      effects on cardiovascular diseases.
FAU - Hanson, Sarah
AU  - Hanson S
AD  - School of Health Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.
FAU - Thorpe, Gabrielle
AU  - Thorpe G
AD  - School of Health Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.
FAU - Winstanley, Lauren
AU  - Winstanley L
AD  - Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK.
FAU - Abdelhamid, Asmaa S
AU  - Abdelhamid AS
AD  - Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK.
FAU - Hooper, Lee
AU  - Hooper L
AUID- ORCID: 0000-0002-7904-3331
AD  - Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK. 
      L.Hooper@uea.ac.uk.
CN  - PUFAH group
LA  - eng
GR  - HQNHD1612458/World Health Organization (WHO)/International
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20200229
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Omega-6)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0RBV727H71 (alpha-Linolenic Acid)
SB  - IM
MH  - Fatty Acids, Omega-3/*administration & dosage
MH  - Fatty Acids, Omega-6/*administration & dosage
MH  - Fatty Acids, Unsaturated/*administration & dosage
MH  - Humans
MH  - Incidence
MH  - Neoplasms/*epidemiology
MH  - Randomized Controlled Trials as Topic
MH  - Risk
MH  - alpha-Linolenic Acid/administration & dosage
PMC - PMC7156752
COIS- S.H., G.T., A.S.A. and L.H. had financial support via the University of East 
      Anglia from the World Health Organization for the submitted work, and L.H. and 
      A.A. were also funded to attend WHO meetings and present review results; no 
      financial relationships with any organisations that might have an interest in the 
      submitted work in the previous three years; no other relationships or activities 
      that could appear to have influenced the submitted work.
FIR - Abdelhamid, Asmaa
IR  - Abdelhamid A
FIR - Ajabnoor, Sarah
IR  - Ajabnoor S
FIR - Alabdulghafoor, Faye
IR  - Alabdulghafoor F
FIR - Alkhudairy, Lena
IR  - Alkhudairy L
FIR - Biswas, Priti
IR  - Biswas P
FIR - Brainard, Julii
IR  - Brainard J
FIR - Bridges, Charlene
IR  - Bridges C
FIR - Brown, Tracey J
IR  - Brown TJ
FIR - Deane, Katherine
IR  - Deane K
FIR - Donaldson, Daisy
IR  - Donaldson D
FIR - Hanson, Sarah
IR  - Hanson S
FIR - Hooper, Lee
IR  - Hooper L
FIR - Jimoh, Oluseyi Florence
IR  - Jimoh OF
FIR - Martin, Nicole
IR  - Martin N
FIR - O'Brien, Alex
IR  - O'Brien A
FIR - Rees, Karen
IR  - Rees K
FIR - Alkhudairy, Lena
IR  - Alkhudairy L
FIR - Song, Fujian
IR  - Song F
FIR - Thorpe, Gabrielle
IR  - Thorpe G
FIR - Wang, Xia
IR  - Wang X
FIR - Winstanley, Lauren
IR  - Winstanley L
EDAT- 2020/03/03 06:00
MHDA- 2020/12/31 06:00
PMCR- 2021/02/28
CRDT- 2020/03/02 06:00
PHST- 2019/10/10 00:00 [received]
PHST- 2020/02/05 00:00 [accepted]
PHST- 2020/01/27 00:00 [revised]
PHST- 2020/03/03 06:00 [pubmed]
PHST- 2020/12/31 06:00 [medline]
PHST- 2020/03/02 06:00 [entrez]
PHST- 2021/02/28 00:00 [pmc-release]
AID - 10.1038/s41416-020-0761-6 [pii]
AID - 761 [pii]
AID - 10.1038/s41416-020-0761-6 [doi]
PST - ppublish
SO  - Br J Cancer. 2020 Apr;122(8):1260-1270. doi: 10.1038/s41416-020-0761-6. Epub 2020 
      Feb 29.