PMID- 32117723
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 10
DP  - 2020
TI  - miR-936 Suppresses Cell Proliferation, Invasion, and Drug Resistance of Laryngeal 
      Squamous Cell Carcinoma and Targets GPR78.
PG  - 60
LID - 10.3389/fonc.2020.00060 [doi]
LID - 60
AB  - MicroRNAs (miRs) play important roles in tumor progression. miR-936 has been 
      reported to suppress cell invasion and proliferation of glioma and non-small cell 
      lung cancer. Nevertheless, the function of miR-936 in laryngeal squamous cell 
      carcinoma (LSCC) remains undiscovered. Hence, our study was to investigate the 
      role of miR-936 in LSCC. In our present research, we have testified that miR-936 
      was substantially downregulated in LSCC tissues compared with adjacent normal 
      tissues. Furthermore, miR-936 could inhibit proliferation, migration and 
      invasion, and improve the sensitivity to doxorubicin and cisplatin of LSCC cells. 
      Additionally, luciferase reporter assays were performed to confirm that GPR78 was 
      a novel target of miR-936, and the protein expression of GPR78 was obviously 
      inhibited by miR-936 in LSCC cells. In summary, our study indicates that the 
      miR-936/GPR78 axis could be both a diagnostic marker and a therapeutic target for 
      LSCC.
CI  - Copyright (c) 2020 Lin, Liu, Li, Wang, Yang, Di, Jiang, Yang, Huang, Yuan, Xing, 
      Wei, Li, Shi and Ye.
FAU - Lin, Xi-Jun
AU  - Lin XJ
AD  - Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated 
      Hospital, Sun Yat-sen University, Guangzhou, China.
FAU - Liu, Hui
AU  - Liu H
AD  - Division of Pulmonary and Critical Care, Department of Internal Medicine, The 
      Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
FAU - Li, Pei
AU  - Li P
AD  - Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated 
      Hospital, Sun Yat-sen University, Guangzhou, China.
FAU - Wang, Hai-Feng
AU  - Wang HF
AD  - Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated 
      Hospital, Sun Yat-sen University, Guangzhou, China.
FAU - Yang, An-Kui
AU  - Yang AK
AD  - Department of Head and Neck, Sun Yat-sen University Cancer Center, Guangzhou, 
      China.
AD  - State Key Laboratory of Oncology in South China, Guangzhou, China.
AD  - Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
FAU - Di, Jin-Ming
AU  - Di JM
AD  - Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Jiang, Qi-Wei
AU  - Jiang QW
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, China.
FAU - Yang, Yang
AU  - Yang Y
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, China.
FAU - Huang, Jia-Rong
AU  - Huang JR
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, China.
FAU - Yuan, Meng-Ling
AU  - Yuan ML
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, China.
FAU - Xing, Zi-Hao
AU  - Xing ZH
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, China.
FAU - Wei, Meng-Ning
AU  - Wei MN
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, China.
FAU - Li, Yao
AU  - Li Y
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, China.
FAU - Shi, Zhi
AU  - Shi Z
AD  - Department of Cell Biology & Institute of Biomedicine, National Engineering 
      Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of 
      Bioengineering Medicine, College of Life Science and Technology, Jinan 
      University, Guangzhou, China.
FAU - Ye, Jin
AU  - Ye J
AD  - Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated 
      Hospital, Sun Yat-sen University, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20200204
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC7011958
OTO - NOTNLM
OT  - GPR78
OT  - drug resistance
OT  - invasion
OT  - laryngeal squamous cell carcinoma
OT  - miR-936
OT  - proliferation
EDAT- 2020/03/03 06:00
MHDA- 2020/03/03 06:01
PMCR- 2020/01/01
CRDT- 2020/03/03 06:00
PHST- 2019/06/27 00:00 [received]
PHST- 2020/01/14 00:00 [accepted]
PHST- 2020/03/03 06:00 [entrez]
PHST- 2020/03/03 06:00 [pubmed]
PHST- 2020/03/03 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2020.00060 [doi]
PST - epublish
SO  - Front Oncol. 2020 Feb 4;10:60. doi: 10.3389/fonc.2020.00060. eCollection 2020.