PMID- 32118761
OWN - NLM
STAT- MEDLINE
DCOM- 20200316
LR  - 20200925
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 9
DP  - 2020 Feb
TI  - Diabetes mellitus as a risk factor for retinal vein occlusion: A meta-analysis.
PG  - e19319
LID - 10.1097/MD.0000000000019319 [doi]
LID - e19319
AB  - Retinal vein occlusion (RVO) is the second most common etiology for vision loss. 
      There is contrasting evidence on the association between diabetes mellitus (DM) 
      and the risk of RVO. We performed a meta-analysis of published articles before 
      October 31, 2019, to estimate a pooled odds ratio for the association between DM 
      and RVO, including central and branch RVO by a fixed or random effects model. We 
      identified 37 publications from 38 studies (1 publication was from 2 studies), 
      published between 1985 and 2019. In total, 148,654 cases and 23,768,820 controls 
      were included in this meta-analysis. The results of pooled analysis for all 37 
      publications (or 38 studies) showed a significant association between DM and the 
      risk of RVO (OR = 1.68, 95% CI: 1.43-1.99). Subgroup analysis indicated that DM 
      was significantly associated with CRVO (OR = 1.98, 95% CI: 1.29-3.03, I = 67.9%), 
      but not significantly associated with BRVO (OR = 1.22, 95% CI: 0.95-1.56, 
      I = 64.1%). In conclusion, the result of present meta-analysis suggested that DM 
      is a risk factor for RVO. More well-designed studies on the relationship between 
      RVO and DM should be undertaken in the future.
FAU - Wang, Yun
AU  - Wang Y
AD  - Department of Ophthalmology, Ningbo Eye Hospital, Ningbo.
FAU - Wu, Shanjun
AU  - Wu S
AD  - Department of Ophthalmology, Ningbo Eye Hospital, Ningbo.
FAU - Wen, Feng
AU  - Wen F
AD  - Department of Ophthalmology, Ningbo Eye Hospital, Ningbo.
FAU - Cao, Qixin
AU  - Cao Q
AD  - Department of Ophthalmology, Huzhou Traditional Chinese Medicine Hospital 
      Affiliated to Zhejiang Chinese Medical University, Huzhou, Zhejiang, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Diabetes Mellitus/*diagnosis/epidemiology
MH  - Humans
MH  - Odds Ratio
MH  - Retinal Vein Occlusion/*diagnosis/epidemiology
MH  - Risk Factors
PMC - PMC7478649
EDAT- 2020/03/03 06:00
MHDA- 2020/03/17 06:00
PMCR- 2020/02/28
CRDT- 2020/03/03 06:00
PHST- 2020/03/03 06:00 [entrez]
PHST- 2020/03/03 06:00 [pubmed]
PHST- 2020/03/17 06:00 [medline]
PHST- 2020/02/28 00:00 [pmc-release]
AID - 00005792-202002280-00061 [pii]
AID - MD-D-19-05821 [pii]
AID - 10.1097/MD.0000000000019319 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Feb;99(9):e19319. doi: 10.1097/MD.0000000000019319.