PMID- 32119803
OWN - NLM
STAT- MEDLINE
DCOM- 20201023
LR  - 20210302
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Print)
IS  - 1096-620X (Linking)
VI  - 23
IP  - 3
DP  - 2020 Mar
TI  - Biochemical, Anthropometric, and Physiological Responses to 
      Carbohydrate-Restricted Diets Versus a Low-Fat Diet in Obese Adults: A Randomized 
      Crossover Trial.
PG  - 206-214
LID - 10.1089/jmf.2019.0266 [doi]
AB  - Some research supports high-fat carbohydrate (CHO)-restricted diets for weight 
      and fat loss and improvement of cardiovascular disease risk factors. To test 
      this, a randomized crossover study was designed. Subjects (17 obese men and women 
      [BMI: 30-38 kg/m(2)]) were fed three diets (supplying 1600 and 2200 kilocalories 
      (kcal)/day for women and men, respectively) for 4 weeks, with each trial 
      separated by 4-week washout periods. One CHO-restricted diet (10% CHO, 50% fat, 
      and 40% protein content) was rich in plant foods and mushrooms, while the other 
      CHO-restricted diet included more animal foods (10% CHO, 60% fat, and 30% protein 
      content). The third diet was lower in fat and protein content (LF) and higher in 
      CHOs (61% CHO, 21% fat, and 18% protein content). Body composition was assessed 
      through hydrostatic weighing before and after each diet trial. Fasting blood 
      samples were collected weekly for analysis of hormones and lipids. Data were 
      analyzed through repeated measures analysis of variance with post hoc paired 
      comparison t-tests. Weight and fat loss were similar (P > .05) among trials. 
      Subjects lost lean mass (P < .05) during CHO-restricted trials, but not in the LF 
      trial. Insulin concentrations decreased (P < .05) during the CHO-restricted trial 
      and tended (P = .05) to decrease during the LF trial. Total cholesterol decreased 
      (P < .05) for all trials; however, high-density lipoprotein cholesterol decreased 
      (P < .05) and triacylglycerols were higher (P < .05) following the LF trial. 
      Taken together, energy restriction regardless of diet composition promoted 
      similar weight loss; however, CHO-restricted diets based on either 
      plants/mushrooms or animal foods elicited a more beneficial lipid-altering effect 
      in comparison with the LF diet.
FAU - Petrisko, Mayumi
AU  - Petrisko M
AD  - School of Exercise and Nutritional Sciences, San Diego State University, San 
      Diego, California, USA.
FAU - Kloss, Rebecca
AU  - Kloss R
AD  - School of Exercise and Nutritional Sciences, San Diego State University, San 
      Diego, California, USA.
FAU - Bradley, Patricia
AU  - Bradley P
AD  - School of Exercise and Nutritional Sciences, San Diego State University, San 
      Diego, California, USA.
FAU - Birrenkott, Erika
AU  - Birrenkott E
AD  - School of Exercise and Nutritional Sciences, San Diego State University, San 
      Diego, California, USA.
FAU - Spindler, Audrey
AU  - Spindler A
AD  - School of Exercise and Nutritional Sciences, San Diego State University, San 
      Diego, California, USA.
FAU - Clayton, Zachary S
AU  - Clayton ZS
AD  - School of Exercise and Nutritional Sciences, San Diego State University, San 
      Diego, California, USA.
FAU - Kern, Mark
AU  - Kern M
AD  - School of Exercise and Nutritional Sciences, San Diego State University, San 
      Diego, California, USA.
LA  - eng
GR  - T32 DK007135/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200302
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Anthropometry
MH  - Body Composition
MH  - Body Mass Index
MH  - Body Weight
MH  - Cholesterol, HDL/blood
MH  - Diet, Carbohydrate-Restricted
MH  - Diet, Fat-Restricted
MH  - Energy Intake
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*diet therapy/metabolism/physiopathology
MH  - Triglycerides/blood
PMC - PMC7207060
OTO - NOTNLM
OT  - animal protein
OT  - carbohydrate restriction
OT  - high fat diet
OT  - low fat diet
OT  - mushrooms
OT  - plant protein
COIS- No competing financial interests exist.
EDAT- 2020/03/03 06:00
MHDA- 2020/10/24 06:00
PMCR- 2021/03/01
CRDT- 2020/03/03 06:00
PHST- 2020/03/03 06:00 [pubmed]
PHST- 2020/10/24 06:00 [medline]
PHST- 2020/03/03 06:00 [entrez]
PHST- 2021/03/01 00:00 [pmc-release]
AID - 10.1089/jmf.2019.0266 [pii]
AID - 10.1089/jmf.2019.0266 [doi]
PST - ppublish
SO  - J Med Food. 2020 Mar;23(3):206-214. doi: 10.1089/jmf.2019.0266. Epub 2020 Mar 2.