PMID- 32119973
OWN - NLM
STAT- MEDLINE
DCOM- 20210429
LR  - 20210429
IS  - 1522-9653 (Electronic)
IS  - 1063-4584 (Linking)
VI  - 28
IP  - 4
DP  - 2020 Apr
TI  - Association between serum immunoglobulin E levels and knee osteoarthritis in 
      Korean adults.
PG  - 462-467
LID - S1063-4584(20)30899-2 [pii]
LID - 10.1016/j.joca.2020.02.830 [doi]
AB  - OBJECTIVE: The objective of this study was to examine whether osteoarthritis (OA) 
      in the knees was associated with total immunoglobulin E (IgE), allergen-specific 
      IgE, or allergic sensitizations in a nationally representative population. 
      METHODS: The study population comprised of 785 adults aged 50 years or more in 
      the Korea National Health and Nutrition Examination Survey 2010. OA was diagnosed 
      as radiographic (rOA) and symptomatic osteoarthritis (sxOA). We performed 
      multivariable logistic regression analyses to investigate relationships of OA in 
      a knee with serum total IgE, allergen (Dermatophagoides farinae, cockroach, and 
      dog allergens)-specific IgE, and allergic sensitizations. RESULTS: Participants 
      with the highest tertile of the total IgE had 92% and 242% increased risk of knee 
      rOA and sxOA, respectively. Those with D. farinae-specific IgE had 2.2 times 
      increased risk of knee sxOA compared to the lowest tertile. Participants with 
      high total IgE (>150kU/L) had a 60% increased risk of knee rOA. Those with 
      D. farinae-specific sensitization (>0.35kU/L) had 2.0 times increased risk of 
      knee sxOA in compared to those without sensitization. Population-attributable 
      fractions of knee rOA caused by high total IgE and knee sxOA caused by 
      D. farinae-specific sensitization were 9.8% and 15.3%, respectively. CONCLUSIONS: 
      Total IgE and D. farinae-specific IgE were significantly associated with OA in 
      knees of Korean adults. High total IgE and D. farinae-specific sensitization were 
      also associated with their OA.
CI  - Copyright (c) 2020 Osteoarthritis Research Society International. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Park, S
AU  - Park S
AD  - Graduate School of Urban Public Health, University of Seoul, Seoul, Republic of 
      Korea.
FAU - Choi, N-K
AU  - Choi NK
AD  - Department of Health Convergence, Ewha Womans University, Seoul, Republic of 
      Korea. Electronic address: nchoi@ewha.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200228
PL  - England
TA  - Osteoarthritis Cartilage
JT  - Osteoarthritis and cartilage
JID - 9305697
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Insect Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Aged
MH  - Allergens/*immunology
MH  - Animals
MH  - Antigens, Dermatophagoides/immunology
MH  - Cockroaches/immunology
MH  - Dogs
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin E/*immunology
MH  - Insect Proteins/immunology
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*immunology
MH  - Republic of Korea
OTO - NOTNLM
OT  - Allergic sensitization
OT  - IgE
OT  - Immunoglobulin E
OT  - Osteoarthritis
EDAT- 2020/03/03 06:00
MHDA- 2021/04/30 06:00
CRDT- 2020/03/03 06:00
PHST- 2019/07/15 00:00 [received]
PHST- 2020/01/30 00:00 [revised]
PHST- 2020/02/13 00:00 [accepted]
PHST- 2020/03/03 06:00 [pubmed]
PHST- 2021/04/30 06:00 [medline]
PHST- 2020/03/03 06:00 [entrez]
AID - S1063-4584(20)30899-2 [pii]
AID - 10.1016/j.joca.2020.02.830 [doi]
PST - ppublish
SO  - Osteoarthritis Cartilage. 2020 Apr;28(4):462-467. doi: 
      10.1016/j.joca.2020.02.830. Epub 2020 Feb 28.