PMID- 32122266
OWN - NLM
STAT- MEDLINE
DCOM- 20210209
LR  - 20210209
IS  - 1557-8534 (Electronic)
IS  - 1547-3287 (Linking)
VI  - 29
IP  - 10
DP  - 2020 May 15
TI  - Donor Selection in HLA-Mismatched Hematopoietic Stem Cell Microtransplantation 
      for Acute Myeloid Leukemia.
PG  - 648-654
LID - 10.1089/scd.2019.0295 [doi]
AB  - To remedy the lack of human leukocyte antigen (HLA)-matched donors and address 
      the problems bedeviling traditional allogeneic hematopoietic stem cell 
      transplantation which induces the resultant graft-versus-host disease, we 
      designed a scheme called HLA-mismatched hematopoietic stem cell 
      microtransplantation (MST) for patients with acute myeloid leukemia (AML), where 
      encouraging results were achieved. In providing answers to such questions as how 
      to select the donors of MST and which factors were involved in the outcome of 
      MST. One hundred thirty-one AML patients from four centers with lower or standard 
      risk of prognosis after complete remission were given three courses of MST: high 
      dose of cytarabine plus infusion of granulocyte colony-stimulating factor 
      mobilized peripheral blood stem cells from HLA-mismatched donors. Leukemia-free 
      survival (LFS) and overall survival were compared, with respect to gender 
      difference, number of HLA-matched loci, killer cell immunoglobulin-like receptor 
      (KIR), and ligand mismatch between donors and recipients. Median LFS of 
      recipients with different KIR ligands from those of donors was found to be 
      significantly higher than that of recipients having identical ligands with donors 
      (P < 0.05). The mean LFS was statistically different between recipients whose 
      donors had HLA-C1/C2 ligand and those whose donors had C1/C1 or C2/C2 ligand 
      (P < 0.05). The following factors were found to promote long-term survival: 
      female recipients of male donors' stem cell, and donors with different KIR 
      ligands from recipients.
FAU - Hu, Kai-Xun
AU  - Hu KX
AD  - Department of Hematology and Transplantation, the Fifth Medical Center of the 
      People's Liberation Army General Hospital, Beijing, China.
FAU - Ai, Hui-Sheng
AU  - Ai HS
AD  - Department of Hematology and Transplantation, the Fifth Medical Center of the 
      People's Liberation Army General Hospital, Beijing, China.
FAU - Guo, Mei
AU  - Guo M
AD  - Department of Hematology and Transplantation, the Fifth Medical Center of the 
      People's Liberation Army General Hospital, Beijing, China.
FAU - Yu, Chang-Lin
AU  - Yu CL
AD  - Department of Hematology and Transplantation, the Fifth Medical Center of the 
      People's Liberation Army General Hospital, Beijing, China.
FAU - Qiao, Jian-Hui
AU  - Qiao JH
AD  - Department of Hematology and Transplantation, the Fifth Medical Center of the 
      People's Liberation Army General Hospital, Beijing, China.
FAU - Sun, Qi-Yun
AU  - Sun QY
AD  - Department of Hematology and Transplantation, the Fifth Medical Center of the 
      People's Liberation Army General Hospital, Beijing, China.
FAU - Dong, Zheng
AU  - Dong Z
AD  - Department of Hematology and Transplantation, the Fifth Medical Center of the 
      People's Liberation Army General Hospital, Beijing, China.
FAU - Cai, Bo
AU  - Cai B
AD  - Department of Hematology and Transplantation, the Fifth Medical Center of the 
      People's Liberation Army General Hospital, Beijing, China.
FAU - Sun, Wan-Jun
AU  - Sun WJ
AD  - Department of Hematology, Second Artillery General Hospital, Beijing, China.
FAU - Wang, Yi
AU  - Wang Y
AD  - Department of Hematology and Transplantation, the Fifth Medical Center of the 
      People's Liberation Army General Hospital, Beijing, China.
FAU - Zhan, Xinrong
AU  - Zhan X
AD  - Department of Hematology, Central Hospital of Xinxiang City, Xinxiang, China.
FAU - Liu, Xiangjun
AU  - Liu X
AD  - Cellular and Molecular Diagnostic Lab of Jing-Meng Hi-Tech Stem Cell, Beijing, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200330
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Disease-Free Survival
MH  - *Donor Selection/methods
MH  - Female
MH  - Graft vs Host Disease/etiology
MH  - Granulocyte Colony-Stimulating Factor/metabolism
MH  - Hematopoietic Stem Cells/immunology/*metabolism
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*metabolism/mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - Remission Induction/methods
MH  - Young Adult
OTO - NOTNLM
OT  - KIR ligand
OT  - NK cells
OT  - acute myeloid leukemia
OT  - hematopoietic stem cell
OT  - microtransplantation
EDAT- 2020/03/04 06:00
MHDA- 2021/02/10 06:00
CRDT- 2020/03/04 06:00
PHST- 2020/03/04 06:00 [pubmed]
PHST- 2021/02/10 06:00 [medline]
PHST- 2020/03/04 06:00 [entrez]
AID - 10.1089/scd.2019.0295 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2020 May 15;29(10):648-654. doi: 10.1089/scd.2019.0295. Epub 2020 
      Mar 30.