PMID- 32122449
OWN - NLM
STAT- MEDLINE
DCOM- 20210106
LR  - 20210106
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 41
IP  - 2
DP  - 2020 Mar 1
TI  - Association of serum 25-OH vitamin D(3) with serum IgE and the Pediatric Asthma 
      Severity Score in patients with pediatric asthma.
PG  - 126-133
LID - 10.2500/aap.2020.41.190025 [doi]
AB  - Background: Pediatric asthma is a prevalent disease and has a significant 
      immunologic and inflammatory nature. In recent years, the role of vitamin D(3) in 
      immunologic processes has been studied, and many aspects of this role have been 
      clarified in some human diseases. Objective: The aim of this study was to 
      evaluate the relationship among the vitamin D(3) status, Pediatric Asthma Severity 
      Score (PASS), and inflammatory indicators of pediatric asthma. Methods: Among all 
      of the pediatric patients with asthma and with asthma exacerbation, 100 patients 
      were randomly enrolled in the study and subdivided into three groups according to 
      serum levels of 25-OH vitamin D(3). The control group consisted of 100 sex- and 
      age-matched healthy subjects. Asthma exacerbation severity was evaluated based on 
      the PASS before starting the medical care. The count of the white blood cells, 
      eosinophil count, and serum levels of total immunoglobulin E (IgE) plus 25-OH 
      vitamin D(3) were measured in all the subjects. The obtained data were then 
      compared via proper statistical tests. A p value of <0.05 was considered as 
      statistically significant. Results: The median level of serum IgE was increased 
      in patients with vitamin D(3) deficiency compared with other groups. There was a 
      significant inverse correlation between serum levels of 25-OH vitamin D(3) and IgE 
      in pediatric patients with asthma (r = -0.483, p = 0.001). Furthermore, the serum 
      levels of 25-OH vitamin D(3) also significantly inversely correlated with the PASS 
      (r = -0.285, p = 0.004). Conclusion: Vitamin D(3) deficiency is associated with 
      exacerbation severity and serum IgE levels in patients with pediatric asthma; 
      hence, it can have an important role in pediatric asthma pathogenesis, possibly 
      through IgE.
FAU - Mohammadzadeh, Iraj
AU  - Mohammadzadeh I
AD  - From the Non-Communicable Pediatric Diseases Research Center, Health Research 
      Institute, Babol University of Medical Sciences, Babol, Iran.
FAU - Darvish, Sorena
AU  - Darvish S
AD  - Infectious Diseases and Tropical Medicine Research Center, Health Research 
      Institute, Babol University of Medical Sciences, Babol, Iran.
FAU - Qujeq, Durdi
AU  - Qujeq D
AD  - Cellular and Molecular Biology Research Center, Health Research Institute, Babol 
      University of Medical Sciences. Babol, Iran.
FAU - Hajiahmadi, Mahmoud
AU  - Hajiahmadi M
AD  - From the Non-Communicable Pediatric Diseases Research Center, Health Research 
      Institute, Babol University of Medical Sciences, Babol, Iran.
FAU - Vaghari-Tabari, Mostafa
AU  - Vaghari-Tabari M
AD  - Department of Clinical Biochemistry and Laboratory Medicine, School of Medicine, 
      Tabriz University of Medical Sciences, Tabriz, Iran, and.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 37341-29-0 (Immunoglobulin E)
RN  - P6YZ13C99Q (Calcifediol)
SB  - IM
MH  - Adolescent
MH  - Asthma/epidemiology/immunology/*metabolism
MH  - Calcifediol/*blood
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Iran/epidemiology
MH  - Male
MH  - Prevalence
MH  - Severity of Illness Index
MH  - Vitamin D Deficiency/*epidemiology
EDAT- 2020/03/04 06:00
MHDA- 2021/01/07 06:00
CRDT- 2020/03/04 06:00
PHST- 2020/03/04 06:00 [entrez]
PHST- 2020/03/04 06:00 [pubmed]
PHST- 2021/01/07 06:00 [medline]
AID - 10.2500/aap.2020.41.190025 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2020 Mar 1;41(2):126-133. doi: 10.2500/aap.2020.41.190025.