PMID- 32125187
OWN - NLM
STAT- MEDLINE
DCOM- 20220530
LR  - 20220601
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 128
IP  - 3
DP  - 2022 Jun
TI  - LncRNA LUADT1 inhibits cell apoptosis in diabetic retinopathy by regulating 
      miR-383/peroxiredoxin 3 axis.
PG  - 637-642
LID - 10.1080/13813455.2020.1716016 [doi]
AB  - This study aimed to investigate the involvement of long non-coding RNA (lncRNA) 
      lung adenocarcinoma transcript 1 (LUADT1) LUADT1 in diabetic retinopathy (DR). We 
      found LUADT1 may interact with miR-383 by RNA interaction prediction. QPCR 
      analysis showed that lncRNA LUADT1 was downregulated, and miR-383 was upregulated 
      in DR. However, correlation analysis revealed no significant correlation between 
      them. In retinal pigment epithelial cells (RPEpiC, h1RPE7 from Sigma-Aldrich), 
      overexpression of LUADT1 and miR-383 failed to affect the expression of each 
      other. However, LUADT1 overexpression led to increased and miR-383 overexpression 
      led to decreased expression level of peroxiredoxin 3 (PRX3). Cell apoptosis 
      analysis showed that LUADT1 and PRX3 overexpression resulted in the decreased 
      cell apoptosis. MiR-383 played an opposite role and reduced the effects of LUADT1 
      and PRX3 overexpression. Therefore, LUADT1 regulates PRX3 by serving as the 
      endogenous sponge of miR-383 in DR to regulate cell apoptosis.
FAU - Dai, Rongfeng
AU  - Dai R
AD  - Department of Endocrinology, The Third People's Hospital of Changzhou, Changzhou, 
      Jiangsu, PR China.
FAU - Sun, Zhuo
AU  - Sun Z
AD  - Department of Ophthalmology, The Third People's Hospital of Changzhou, Changzhou, 
      Jiangsu, PR China.
FAU - Qian, Yu
AU  - Qian Y
AD  - Department of Endocrinology, The Third People's Hospital of Changzhou, Changzhou, 
      Jiangsu, PR China.
FAU - Zhang, Bei
AU  - Zhang B
AD  - Department of Ophthalmology, The Third People's Hospital of Changzhou, Changzhou, 
      Jiangsu, PR China.
FAU - Han, Yan
AU  - Han Y
AD  - Department of Endocrinology, The Third People's Hospital of Changzhou, Changzhou, 
      Jiangsu, PR China.
FAU - Deng, Guohua
AU  - Deng G
AD  - Department of Ophthalmology, The Third People's Hospital of Changzhou, Changzhou, 
      Jiangsu, PR China.
LA  - eng
PT  - Journal Article
DEP - 20200303
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (MIRN383 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
RN  - EC 1.11.1.15 (PRDX3 protein, human)
RN  - EC 1.11.1.15 (Peroxiredoxin III)
SB  - IM
MH  - Apoptosis
MH  - *Diabetes Mellitus
MH  - *Diabetic Retinopathy/genetics
MH  - Humans
MH  - *MicroRNAs/genetics
MH  - *Peroxiredoxin III/genetics
MH  - *RNA, Long Noncoding/genetics
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - LUADT1
OT  - apoptosis
OT  - miR-383
OT  - peroxiredoxin 3
EDAT- 2020/03/04 06:00
MHDA- 2022/05/31 06:00
CRDT- 2020/03/04 06:00
PHST- 2020/03/04 06:00 [pubmed]
PHST- 2022/05/31 06:00 [medline]
PHST- 2020/03/04 06:00 [entrez]
AID - 10.1080/13813455.2020.1716016 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2022 Jun;128(3):637-642. doi: 
      10.1080/13813455.2020.1716016. Epub 2020 Mar 3.