PMID- 32125615
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1931-7565 (Electronic)
IS  - 1931-7557 (Linking)
VI  - 15
IP  - 1
DP  - 2021 Feb
TI  - Smaller volume of right hippocampal CA2/3 in patients with panic disorder.
PG  - 320-326
LID - 10.1007/s11682-020-00259-w [doi]
AB  - The hippocampus is thought to play an important role in conveying contextual 
      information to the amygdala as the neural basis of panic disorder (PD). Previous 
      studies have revealed functional abnormalities in the hippocampus in patients 
      with PD compared with healthy control subjects (HC), but no study has reported 
      volume abnormalities in the hippocampus or evaluated minute structural changes in 
      the hippocampus in such patients. We thus investigated volume abnormalities in 
      the subfields of the hippocampus to better understand the neurobiological basis 
      of PD. The hippocampus was extracted from structural brain magnetic resonance 
      images obtained from 38 patients with PD and 38 HC and then segmented into six 
      subfields. The relative volume of each subfield was compared between the two 
      groups. The severity of symptoms was assessed using the Panic Disorder Severity 
      Scale (PDSS) and social functioning was assessed using the Global Assessment of 
      Functioning (GAF) scale. Our results revealed that patients with PD had a 
      significantly smaller volume of the right cornu ammonis (CA) 2/3 hippocampal 
      subfield compared with HC. No significant associations were found between the 
      volumes of the right CA 2/3 and the PDSS or GAF scores in correlation analyses. 
      In conclusion, CA2/3 is thought to be related to contextual memory function, and 
      our results suggest that this particular hippocampal subfield plays a role in the 
      development of PD symptoms.
FAU - Takaishi, Masao
AU  - Takaishi M
AD  - Department of Psychiatry, Graduate School of Medicine, Yokohama City University, 
      3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan.
FAU - Asami, Takeshi
AU  - Asami T
AUID- ORCID: 0000-0003-1269-5965
AD  - Department of Psychiatry, Graduate School of Medicine, Yokohama City University, 
      3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan. t_asami@yokohama-cu.ac.jp.
FAU - Yoshida, Haruhisa
AU  - Yoshida H
AD  - Department of Psychiatry, Graduate School of Medicine, Yokohama City University, 
      3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan.
FAU - Nakamura, Ryota
AU  - Nakamura R
AD  - Department of Psychiatry, Graduate School of Medicine, Yokohama City University, 
      3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan.
FAU - Yoshimi, Asuka
AU  - Yoshimi A
AD  - Department of Psychiatry, Graduate School of Medicine, Yokohama City University, 
      3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan.
FAU - Hirayasu, Yoshio
AU  - Hirayasu Y
AD  - Department of Psychiatry, Graduate School of Medicine, Yokohama City University, 
      3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan.
AD  - Heian Hospital, Okinawa, Japan.
LA  - eng
GR  - 200400762A,/Ministry of Health, Labor and Welfare/
GR  - 200500806A/Ministry of Health, Labor and Welfare/
GR  - 200632005A, B/Ministry of Health, Labor and Welfare/
GR  - JP25861023/JSPS KAKENHI/
GR  - JP17K10313/JSPS KAKENHI/
PT  - Journal Article
PL  - United States
TA  - Brain Imaging Behav
JT  - Brain imaging and behavior
JID - 101300405
SB  - IM
MH  - Amygdala
MH  - Hippocampus/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Organ Size
MH  - *Panic Disorder/diagnostic imaging
OTO - NOTNLM
OT  - Cornu ammonis
OT  - Hippocampal subfield
OT  - Hippocampus
OT  - MRI
OT  - Panic disorder
OT  - Volume
EDAT- 2020/03/04 06:00
MHDA- 2021/04/28 06:00
CRDT- 2020/03/04 06:00
PHST- 2020/03/04 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2020/03/04 06:00 [entrez]
AID - 10.1007/s11682-020-00259-w [pii]
AID - 10.1007/s11682-020-00259-w [doi]
PST - ppublish
SO  - Brain Imaging Behav. 2021 Feb;15(1):320-326. doi: 10.1007/s11682-020-00259-w.