PMID- 32125862
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20210528
IS  - 1543-8392 (Electronic)
IS  - 1543-8384 (Linking)
VI  - 17
IP  - 4
DP  - 2020 Apr 6
TI  - Dual Stimuli-Responsive Supramolecular Self-Assemblies Based on the Host-Guest 
      Interaction between beta-Cyclodextrin and Azobenzene for Cellular Drug Release.
PG  - 1100-1113
LID - 10.1021/acs.molpharmaceut.9b01142 [doi]
AB  - Health has always been a hot topic of concern, whereas cancer is one of the 
      largest security risks to human health. Although the existing drug delivery 
      systems (DDSs) have been extensively reported and commercially applied, there are 
      still some issues that have yet to be well-resolved, including the toxicity, 
      side-effects, and targeted therapy efficiency of drugs. Consequently, it is still 
      necessary to develop a novel, highly efficient, controlled and targeted DDS for 
      cancer therapy. For this, a supramolecular polymer, beta-CD-g-PDMAEMA@Azo-PCL, was 
      designed and developed through the host-guest inclusion complexation interactions 
      between a host polymer, beta-cyclodextrin-graft-poly(2-(dimethylamino)ethyl 
      methacrylate) (beta-CD-g-PDMAEMA), and a guest polymer, azobenzene modified 
      poly(epsilon-caprolactone) (Azo-PCL), and was characterized by various analysis 
      techniques. The supramolecular assembly was examined in various pH environments 
      and/or under UV-vis irradiation, showing the formation of supramolecular 
      assemblies from regular spherical shapes to irregular aggregates with various 
      hydrodynamic diameters. The 2D NOESY NMR studies showed the formation of 
      inclusion complexation between Azo-PCL and beta-CD-g-PDMAEMA and between beta-CD and 
      the side groups of PDMAEMA. The supramolecular assemblies could encapsulate 
      doxorubicin to form spherical core-shell drug-carrying micelles with an 
      entrapment efficiency of 66.1%. The effects of external environment stimuli on 
      the in vitro drug release were investigated, showing light- and pH-modulated drug 
      release properties. The cytotoxicity assessment indicated that the blank 
      supramolecular micelles were nontoxic, whereas the drug-loaded micelles exhibited 
      comparable or even superior anticancer activity to the anticancer activity of 
      free DOX and inhibition of cancer cell proliferation. Therefore, the developed 
      supramolecular assemblies can potentially be used as drug-controlled release 
      carriers.
FAU - Zhang, JianGuo
AU  - Zhang J
AD  - Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry 
      and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, P.R. China.
FAU - Zhou, Zi-Hao
AU  - Zhou ZH
AD  - Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry 
      and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, P.R. China.
FAU - Li, Lin
AU  - Li L
AD  - Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry 
      and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, P.R. China.
FAU - Luo, Yan-Ling
AU  - Luo YL
AUID- ORCID: 0000-0003-0470-5393
AD  - Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry 
      and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, P.R. China.
FAU - Xu, Feng
AU  - Xu F
AD  - Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry 
      and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, P.R. China.
FAU - Chen, Yashao
AU  - Chen Y
AUID- ORCID: 0000-0002-1230-8446
AD  - Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry 
      and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200311
PL  - United States
TA  - Mol Pharm
JT  - Molecular pharmaceutics
JID - 101197791
RN  - 0 (Azo Compounds)
RN  - 0 (Caproates)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Lactones)
RN  - 0 (Methacrylates)
RN  - 0 (Micelles)
RN  - 0 (Nylons)
RN  - 0 (Polymers)
RN  - 0 (beta-Cyclodextrins)
RN  - 0 (poly(2-(dimethylamino)ethyl methacrylate))
RN  - 56RE988L1R (caprolactone)
RN  - 80168379AG (Doxorubicin)
RN  - F0U1H6UG5C (azobenzene)
SB  - IM
MH  - Azo Compounds/*chemistry/pharmacology
MH  - Caproates/chemistry/pharmacology
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Delayed-Action Preparations/chemistry/pharmacology
MH  - Doxorubicin/chemistry/pharmacology
MH  - Drug Delivery Systems/methods
MH  - Drug Liberation/*physiology
MH  - HeLa Cells
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Lactones/chemistry/pharmacology
MH  - Methacrylates/chemistry
MH  - Micelles
MH  - Nylons/chemistry
MH  - Polymers/chemistry
MH  - beta-Cyclodextrins/*chemistry/pharmacology
OTO - NOTNLM
OT  - azobenzene
OT  - host-guest interactions
OT  - stimulus responsiveness
OT  - beta-cyclodextrin
EDAT- 2020/03/04 06:00
MHDA- 2021/05/29 06:00
CRDT- 2020/03/04 06:00
PHST- 2020/03/04 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
PHST- 2020/03/04 06:00 [entrez]
AID - 10.1021/acs.molpharmaceut.9b01142 [doi]
PST - ppublish
SO  - Mol Pharm. 2020 Apr 6;17(4):1100-1113. doi: 10.1021/acs.molpharmaceut.9b01142. 
      Epub 2020 Mar 11.