PMID- 32126303
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20210628
IS  - 1567-7257 (Electronic)
IS  - 1567-1348 (Linking)
VI  - 81
DP  - 2020 Jul
TI  - From role of gut microbiota to microbial-based therapies in type 2-diabetes.
PG  - 104268
LID - S1567-1348(20)30099-X [pii]
LID - 10.1016/j.meegid.2020.104268 [doi]
AB  - The incidence of type 2 diabetes mellitus (T2DM) has increased dramatically at an 
      alarming level around the world.T2DM is associated with changeable risk factors 
      in lifestyle as well as genetic and family associated risk factors. More 
      importantly, imbalanced or impaired gut microbial distribution (dysbiosis) has 
      been reported as a contributing risk factor in insulin resistance progression in 
      T2DM. Dysbiosis may restructure the metabolic and functional pathways in the 
      intestine which are involved in the development of T2DM. However, several studies 
      have indicated the constructive and helpful effect of prebiotics, probiotics, and 
      fecal microbiota transplantation (FMT) on the improvement of gut microbiota (GM) 
      and accordingly host metabolism. In this review, the association between GM and 
      T2DM have been evaluated and the role of prebiotics, probiotics and FMT, as 
      potential therapeutic approaches have been discussed. Relevant studies were 
      obtained randomly from online databases such as PubMed/Medline and ISI Web of 
      Science.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Ebrahimzadeh Leylabadlo, Hamed
AU  - Ebrahimzadeh Leylabadlo H
AD  - Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical 
      Sciences, Tabriz, Iran; Department of Bacteriology and Virology, Faculty of 
      Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Sanaie, Sarvin
AU  - Sanaie S
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; 
      Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Sadeghpour Heravi, Fatemah
AU  - Sadeghpour Heravi F
AD  - Surgical Infection Research Group, Faculty of Medicine and Health Science, 
      Macquarie University, Sydney 2019, Australia.
FAU - Ahmadian, Zainab
AU  - Ahmadian Z
AD  - Department of Pharmaceutics, School of Pharmacy, Zanjan University of Medical 
      Science, 45139-56184 Zanjan, Iran.
FAU - Ghotaslou, Reza
AU  - Ghotaslou R
AD  - Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical 
      Sciences, Tabriz, Iran; Department of Bacteriology and Virology, Faculty of 
      Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic 
      address: rzgottaslo@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200229
PL  - Netherlands
TA  - Infect Genet Evol
JT  - Infection, genetics and evolution : journal of molecular epidemiology and 
      evolutionary genetics in infectious diseases
JID - 101084138
RN  - 0 (Prebiotics)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*microbiology/*therapy
MH  - Dysbiosis/microbiology/therapy
MH  - Fecal Microbiota Transplantation/methods
MH  - Gastrointestinal Microbiome/*physiology
MH  - Humans
MH  - Prebiotics/microbiology
MH  - Probiotics/therapeutic use
OTO - NOTNLM
OT  - Microbiome
OT  - Microbiota
OT  - Prebiotics
OT  - Probiotics
OT  - Type 2 diabetes
COIS- Declaration of Competing Interest None.
EDAT- 2020/03/04 06:00
MHDA- 2021/06/29 06:00
CRDT- 2020/03/04 06:00
PHST- 2020/01/15 00:00 [received]
PHST- 2020/02/18 00:00 [revised]
PHST- 2020/02/27 00:00 [accepted]
PHST- 2020/03/04 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2020/03/04 06:00 [entrez]
AID - S1567-1348(20)30099-X [pii]
AID - 10.1016/j.meegid.2020.104268 [doi]
PST - ppublish
SO  - Infect Genet Evol. 2020 Jul;81:104268. doi: 10.1016/j.meegid.2020.104268. Epub 
      2020 Feb 29.