PMID- 32126567
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20240412
IS  - 1423-0267 (Electronic)
IS  - 0030-3755 (Linking)
VI  - 243
IP  - 5
DP  - 2020
TI  - Predicting Progression of Untreated Macular Pucker Using Retinal Surface En Face 
      Optical Coherence Tomography.
PG  - 323-333
LID - 10.1159/000497490 [doi]
AB  - PURPOSE: To review visual outcomes in untreated premacular membrane (PMM) with 
      macular pucker (MP) and evaluate novel predictors of progression. METHODS: In 
      this retrospective observation study, we included 342 eyes with untreated PMM 
      with MP between 2012 and 2015. PMMs were characterized by spectral-domain optical 
      coherence tomography (SD-OCT) imaging based on foveal morphologies, number of 
      retinal contraction centers, central subfield thickness (CST), inner segment 
      ellipsoid band integrity, and photoreceptor deformation index. Additionally, the 
      thickened retina portion was identified by en face OCT and processed digitally to 
      calculate its area. Parameters were retrospectively analyzed using multiple 
      regression analyses to identify associations with change in visual acuity (VA) 
      between initial to final follow-up visit. RESULTS: In 468 eyes with untreated 
      PMM, VA and CST did not change significantly during a mean observation period of 
      448 days (p = 0.52 and 0.35, respectively). Specifically, VA improved or stayed 
      the same in 80% and worsened by 2 lines or more in 20% of eyes. The only 
      consistent predictor of PMM progression was area of retinal thickening: for every 
      1 mm2 of retinal thickening at baseline, the odds of having worsened vision at 
      follow-up increased by 6% (OR 1.0606, 95% CI 1.0031-1.1214, p = 0.0387). 
      CONCLUSIONS: The majority of eyes with PMM and good visual function at baseline 
      remain stable or spontaneously improve in VA and macular thickness. Area of 
      retinal thickening as evaluated by en face OCT may be a novel predictor of vision 
      loss in untreated PMM with MP.
CI  - (c) 2019 S. Karger AG, Basel.
FAU - Li, Daniel Q
AU  - Li DQ
AD  - Department of Ophthalmology and Visual Sciences, McGill University, Montreal, 
      Quebec, Canada.
FAU - Rudkin, Adam K
AU  - Rudkin AK
AD  - Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, 
      Ontario, Canada.
AD  - St. Michael's Hospital, Toronto, Ontario, Canada.
FAU - Altomare, Filiberto
AU  - Altomare F
AD  - Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, 
      Ontario, Canada.
AD  - St. Michael's Hospital, Toronto, Ontario, Canada.
FAU - Giavedoni, Louis
AU  - Giavedoni L
AD  - Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, 
      Ontario, Canada.
AD  - St. Michael's Hospital, Toronto, Ontario, Canada.
FAU - Wong, David T
AU  - Wong DT
AD  - Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, 
      Ontario, Canada, WONGD@smh.ca.
AD  - St. Michael's Hospital, Toronto, Ontario, Canada, WONGD@smh.ca.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20200303
PL  - Switzerland
TA  - Ophthalmologica
JT  - Ophthalmologica. Journal international d'ophtalmologie. International journal of 
      ophthalmology. Zeitschrift fur Augenheilkunde
JID - 0054655
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Macular Edema/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retina/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
OTO - NOTNLM
OT  - Optical coherence tomography
OT  - Premacular membrane
EDAT- 2020/03/04 06:00
MHDA- 2021/06/24 06:00
CRDT- 2020/03/04 06:00
PHST- 2018/10/05 00:00 [received]
PHST- 2019/02/04 00:00 [accepted]
PHST- 2020/03/04 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2020/03/04 06:00 [entrez]
AID - 000497490 [pii]
AID - 10.1159/000497490 [doi]
PST - ppublish
SO  - Ophthalmologica. 2020;243(5):323-333. doi: 10.1159/000497490. Epub 2020 Mar 3.