PMID- 32126726
OWN - NLM
STAT- MEDLINE
DCOM- 20210531
LR  - 20210531
IS  - 1533-4899 (Electronic)
IS  - 1533-4880 (Linking)
VI  - 20
IP  - 8
DP  - 2020 Aug 1
TI  - Montmorillonite Intercalated Norfloxacin and Tobramycin for New Drug-Delivery 
      Systems.
PG  - 5246-5251
LID - 10.1166/jnn.2020.18532 [doi]
AB  - The urgent need of safe, therapeutically and patient-compliant drug delivery 
      systems (DDSs) continuously stimulates researchers to explore novel tools and 
      strategies to monitor the loading and release of drugs. In this context, this 
      study demonstrates that montmorillonite clay (MMT) is an appropriate material for 
      changing the release behavior of Tobramycin and Norfloxacin drugs into medium. 
      The DDSs were prepared by the intercalation of Tobramycin or Norfloxacin between 
      MMT layers. The MMT-drug systems were analyzed using X-ray diffraction (XRD) 
      analysis, scanning electron microscope (SEM), and Fourier transforms infrared 
      (FT-IR). After insertion of the drugs between the layers of MMT, the periodicity 
      in c-axis changed because of the formation of layered hybrid structures. The 
      release of drugs was investigated using UV-spectrophotometer. The release rates 
      are found to be dependent on pH of the medium. Moreover, we found that the 
      percentage of release increases as the pH increases, however the release rate is 
      low. These findings would be beneficial for controlled release of drugs for 
      prolonged time in the future.
FAU - Kenawy, El-Refaie
AU  - Kenawy ER
AD  - Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
FAU - Shaker, Nehal O
AU  - Shaker NO
AD  - Chemistry Department, Faculty of Science, Al-Azhar University, Cairo 11651, 
      Egypt.
FAU - Azaam, Mohamed
AU  - Azaam M
AD  - Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
FAU - Lasheen, Aya S
AU  - Lasheen AS
AD  - Chemistry Department, Faculty of Science, Al-Azhar University, Cairo 11651, 
      Egypt.
FAU - Lin, Jianjian
AU  - Lin J
AD  - Key Laboratory of Eco-Chemical Engineering, College of Chemistry and Molecular 
      Engineering, Qingdao University of Science and Technology (QUST), Qingdao 266042, 
      China.
FAU - Zakaria, Mohamed B
AU  - Zakaria MB
AD  - Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nanosci Nanotechnol
JT  - Journal of nanoscience and nanotechnology
JID - 101088195
RN  - 1302-78-9 (Bentonite)
RN  - N0F8P22L1P (Norfloxacin)
RN  - VZ8RRZ51VK (Tobramycin)
SB  - IM
MH  - *Bentonite
MH  - Drug Delivery Systems
MH  - Humans
MH  - *Norfloxacin
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Tobramycin
MH  - X-Ray Diffraction
EDAT- 2020/03/05 06:00
MHDA- 2021/06/01 06:00
CRDT- 2020/03/05 06:00
PHST- 2020/03/05 06:00 [entrez]
PHST- 2020/03/05 06:00 [pubmed]
PHST- 2021/06/01 06:00 [medline]
AID - 10.1166/jnn.2020.18532 [doi]
PST - ppublish
SO  - J Nanosci Nanotechnol. 2020 Aug 1;20(8):5246-5251. doi: 10.1166/jnn.2020.18532.