PMID- 32128023
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 1939-4551 (Print)
IS  - 1939-4551 (Electronic)
IS  - 1939-4551 (Linking)
VI  - 13
IP  - 2
DP  - 2020 Feb
TI  - IgE allergy diagnostics and other relevant tests in allergy, a World Allergy 
      Organization position paper.
PG  - 100080
LID - 10.1016/j.waojou.2019.100080 [doi]
LID - 100080
AB  - Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of 
      diagnostic evaluation in suspected allergic conditions. This review provides a 
      thorough and updated critical appraisal of the most frequently used diagnostic 
      tests, both in vivo and in vitro. It discusses skin tests, challenges, and 
      serological and cellular in vitro tests, and provides an overview of indications, 
      advantages and disadvantages of each in conditions such as respiratory, food, 
      venom, drug, and occupational allergy. Skin prick testing remains the first line 
      approach in most instances; the added value of serum specific IgE to whole 
      allergen extracts or components, as well as the role of basophil activation 
      tests, is evaluated. Unproven, non-validated, diagnostic tests are also 
      discussed. Throughout the review, the reader must bear in mind the relevance of 
      differentiating between sensitization and allergy; the latter entails not only 
      allergic sensitization, but also clinically relevant symptoms triggered by the 
      culprit allergen.
CI  - (c) 2019 The Authors.
FAU - Ansotegui, Ignacio J
AU  - Ansotegui IJ
AD  - Hospital Quironsalud Bizkaia, Bilbao-Erandio, Spain.
FAU - Melioli, Giovanni
AU  - Melioli G
AD  - Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, 
      Italy.
FAU - Canonica, Giorgio Walter
AU  - Canonica GW
AD  - Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 
      Personalized Medicine, Asthma and Allergy, Humanitas Research Hospital, Rozzano, 
      Milan, Italy.
FAU - Caraballo, Luis
AU  - Caraballo L
AD  - Institute for Immunological Research, University of Cartagena, Cartagena, 
      Colombia.
FAU - Villa, Elisa
AU  - Villa E
AD  - Azienda Sanitaria Locale di Vercelli, S.C. Pneumologia, Vercelli, Italia.
FAU - Ebisawa, Motohiro
AU  - Ebisawa M
AD  - Clinical Research Center for Allergy and Rheumatology, Sagamihara National 
      Hospital, Sagamihara, Kanagawa, Japan.
FAU - Passalacqua, Giovanni
AU  - Passalacqua G
AD  - Allergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of 
      Genoa, Genoa, Italy.
FAU - Savi, Eleonora
AU  - Savi E
AD  - Ospedale Civile, Gossolengo, PC, Italy.
FAU - Ebo, Didier
AU  - Ebo D
AD  - Department of Immunology - Allergology - Rheumatology, Antwerp University 
      Hospital, Antwerp University, Department Immunology and Allergology, AZ Jan 
      Palfijn Gent, Ghent, Belgium.
FAU - Gomez, R Maximiliano
AU  - Gomez RM
AD  - Universidad Catolica de Salta, Fundacion Ayre, Buenos Aires, Argentina.
FAU - Luengo Sanchez, Olga
AU  - Luengo Sanchez O
AD  - Allergy Section, Department of Internal Medicine, Vall d'Hebron University 
      Hospital, Barcelona, Spain.
FAU - Oppenheimer, John J
AU  - Oppenheimer JJ
AD  - Pulmonary & Allergy Associates, Denville, NJ, USA.
FAU - Jensen-Jarolim, Erika
AU  - Jensen-Jarolim E
AD  - Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, 
      Infectiology and Immunology, The Interuniversity Messerli Research Institute, 
      University of Veterinary Medicine Vienna, Medical University Vienna, Vienna, 
      Austria.
FAU - Fischer, David A
AU  - Fischer DA
AD  - Fischer Medicine Professional Corporation, Barrie, Ontario, Canada.
FAU - Haahtela, Tari
AU  - Haahtela T
AD  - Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland.
FAU - Antila, Martti
AU  - Antila M
AD  - Clinica de Alergia, Sorocaba, Sao Paulo, Brazil.
FAU - Bousquet, Jean J
AU  - Bousquet JJ
AD  - MACVIA-France, Montpellier, France.
AD  - INSERM, Villejuif, France.
AD  - Universite Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux, France.
AD  - Euforea, Brussels, Belgium.
AD  - CHU Montpellier, France.
FAU - Cardona, Victoria
AU  - Cardona V
AD  - Universitat Autonoma de Barcelona, Hospital Universitario Vall d'Hebron, Servicio 
      de Medicina Interna, Seccion de Alergologia, Barcelona, Spain.
FAU - Chiang, Wen Chin
AU  - Chiang WC
AD  - Mount Elizabeth Medical Centre, Chiang Children's Allergy & Asthma Clinic, 
      Singapore, Singapore.
FAU - Demoly, Pascal M
AU  - Demoly PM
AD  - University Hospital Montpellier, Montpellier, France.
AD  - Sorbonne Universite, Paris, France.
FAU - DuBuske, Lawrence M
AU  - DuBuske LM
AD  - Immunology Research Institute of New England, Gardner, MA, USA.
FAU - Ferrer Puga, Marta
AU  - Ferrer Puga M
AD  - The Unidad de Educacion Medica, Department of Medical Education, School of 
      Medicine, Clinica Universitad de Navarra, Navarra, Spain.
FAU - Gerth van Wijk, Roy
AU  - Gerth van Wijk R
AD  - Erasmus MC, Sector Allergologie, Rotterdam, the Netherlands.
FAU - Gonzalez Diaz, Sandra Nora
AU  - Gonzalez Diaz SN
AD  - Universidad Autonoma de Nuevo Leon, Hospital Universitario, Monterrey, Nuevo 
      Leon, Mexico.
FAU - Gonzalez-Estrada, Alexei
AU  - Gonzalez-Estrada A
AD  - Department of Allergy, Mayo Clinic, Jacksonville, FL, USA.
FAU - Jares, Edgardo
AU  - Jares E
AD  - Femeca Femedica, Buenos Aires, Argentina.
FAU - Kalpaklioglu, Ayse Fusun
AU  - Kalpaklioglu AF
AD  - Kirikkale Universitesi, Tip Fakultesi, Kirikkale, Turkey.
FAU - Kase Tanno, Luciana
AU  - Kase Tanno L
AD  - Hospital Sirio Libanes, University of Sao Paulo, Sao Paulo, Brazil.
FAU - Kowalski, Marek L
AU  - Kowalski ML
AD  - Faculty of Medicine, Department of Clinical Immunology & Allergy, Medical 
      University of Lodz, Lodz, Poland.
FAU - Ledford, Dennis K
AU  - Ledford DK
AD  - University of South Florida College of Medicine, Tampa, FL, USA.
FAU - Monge Ortega, Olga Patricia
AU  - Monge Ortega OP
AD  - Allergology Unit, San Juan de Dios Hospital, University of Costa Rica, San Jose, 
      Costa Rica.
FAU - Morais Almeida, Mario
AU  - Morais Almeida M
AD  - Hospital CUF-Descobertas, Lisbon, Portugal.
FAU - Pfaar, Oliver
AU  - Pfaar O
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology 
      and Allergy, University Hospital Marburg, Philipps-Universitat Marburg, Marburg, 
      Germany.
FAU - Poulsen, Lars K
AU  - Poulsen LK
AD  - Gentofte University Hospital, Lab for Allergology, Allergy Clinic, Hellerup, 
      Denmark.
FAU - Pawankar, Ruby
AU  - Pawankar R
AD  - Nippon Medical School, Dept. of Otolaryngology, Tokyo, Japan.
FAU - Renz, Harald E
AU  - Renz HE
AD  - University Hospital GI & MR GmbH, Institute of Laboratory Medicine & Pathology, 
      Standort Marburg, Marburg, Germany.
FAU - Romano, Antonino G
AU  - Romano AG
AD  - Stallergenes, Rome, Italy.
FAU - Rosario Filho, Nelson A
AU  - Rosario Filho NA
AD  - University of Parana, Curitiba, PR, Brazil.
FAU - Rosenwasser, Lanny
AU  - Rosenwasser L
AD  - University of Missouri at Kansas City, School of Medicine, Kansas City, MO, USA.
FAU - Sanchez Borges, Mario A
AU  - Sanchez Borges MA
AD  - Centro Medico Docente La Trinidad, Caracas, Venezuela.
FAU - Scala, Enrico
AU  - Scala E
AD  - Experimental Allergy Unit, Istituto Dermopatico dell'Immacolata, Rome, Italy.
FAU - Senna, Gian-Enrico
AU  - Senna GE
AD  - Ospedale Civile Maggiore, Verona, Italy.
FAU - Sisul, Juan Carlos
AU  - Sisul JC
AD  - Allergy & Asthma Institute, Asuncion, Paraguay.
FAU - Tang, Mimi L K
AU  - Tang MLK
AD  - Royal Children's Hospital, Department of Allergy & Immunology, Parkville, 
      Victoria, Australia.
FAU - Thong, Bernard Yu-Hor
AU  - Thong BY
AD  - Tan Tock Seng Hospital, Deptartment of Rheumatology, Allergy & Immunology, 
      Singapore, Singapore.
FAU - Valenta, Rudolf
AU  - Valenta R
AD  - Division of Immunopathology, Department of Pathophysiology and Allergy Research, 
      Center for Pathophysiology, Infectiology and Immunology, Medical University of 
      Vienna, Vienna, Austria.
AD  - NRC Institute of Immunology FMBA of Russia, Moscow, Russia.
AD  - Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, 
      Sechenov First Moscow State Medical University, Moscow, Russia.
FAU - Wood, Robert A
AU  - Wood RA
AD  - Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, 
      MD, USA.
FAU - Zuberbier, Torsten
AU  - Zuberbier T
AD  - Campus Charite Mitte, Klinik fur Dermatologie & Allergologie, Berlin, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200225
PL  - United States
TA  - World Allergy Organ J
JT  - The World Allergy Organization journal
JID - 101481283
EIN - World Allergy Organ J. 2021 Jun 17;14(7):100557. PMID: 34221218
PMC - PMC7044795
OTO - NOTNLM
OT  - AAAAI, American Academy of Allergy Asthma and Immunology
OT  - ABA, Allergen Bead Array
OT  - ACAAI, American College of Allergy Asthma and Immunology
OT  - AEC, Allergen Exposure Chambers
OT  - AIT, allergen immunotherapy
OT  - AP, Alkaline Phosphatase
OT  - AU/mL, Allergenic Units milliLiter
OT  - Allergy
OT  - Anti-IgE, Antibody against IgE
OT  - BAT, Basophil Activation Test
OT  - BAU/mL, Biologic Allergenic Units milliLiter
OT  - CBA, Cytometric Bead Array
OT  - CCD, Cross-reactive Carbohydrate Determinants
OT  - CDER, Center for Drug Evaluation and Research (USA)
OT  - CL, Chemiluminescence
OT  - CaFE, Calibrated Fluorescence Enhancement
OT  - DBPCFC, Double-Blind Placebo-Controlled Food Challenge
OT  - Diagnostic strategies
OT  - EAACI, European Academy of Allergy and Immunology
OT  - EIA, Enzyme Immune Assay
OT  - ELISA, Enzyme Linked Immuno Sorbent Analysis
OT  - EMEA, European MEdicine Agencies
OT  - ENPP-3, EctoNucleotide Pyrophosphatase/Phosphodiesterase 3
OT  - FACS, Fluorescence-Activated Cell Sorting
OT  - FDA, Food and Drug Administration (U.S. Department of Health and Human Services)
OT  - FEIA, Fluorescent Enzyme Immunoassays
OT  - FcepsilonRI, High affinity IgE receptor
OT  - H1, Histamine 1 receptor
OT  - H2, Histamine 2 receptor
OT  - HPO, Horseradish Peroxidase
OT  - IDT, Intradermal Test
OT  - ISAC, Immuno-Solid phase Allergen Chip
OT  - IUIS, International Union of Immunological Societies
OT  - IVD, in vitro diagnostic tool
OT  - IgE
OT  - IgE, immunoglobulin E
OT  - In vitro tests
OT  - LAMP-3, Lysosomal-Associated Membrane Protein
OT  - MBAD, Molecule Based Allergy Diagnostics
OT  - MRGPRX2, Mas-related G protein receptor 2
OT  - NIH, National Institutes of Health (USA)
OT  - NMBAs, NeuroMuscular Blocking Agents
OT  - NPA, Negative Percent Agreement
OT  - NSAIDs, Non-Steroidal Anti-Inflammatory Drugs
OT  - PPA, Positive Percent Agreement
OT  - PPT, Prick-Prick Test
OT  - RAST, Radio Allergo Sorbent Test
OT  - SCAR, severe cutaneous adverse drug reactions
OT  - SPT, Skin prick test
OT  - Skin tests
OT  - kUA/L, kilo Units of Allergen/Liter for allergen-specific IgE antibody assays
OT  - mAb, Monoclonal Antibody
OT  - pNPP, p-Nitrophenylphosphate
OT  - sIgE, specific IgE
OT  - w/v, weight /volume
EDAT- 2020/03/05 06:00
MHDA- 2020/03/05 06:01
PMCR- 2020/02/25
CRDT- 2020/03/05 06:00
PHST- 2019/08/15 00:00 [received]
PHST- 2019/10/08 00:00 [accepted]
PHST- 2020/03/05 06:00 [entrez]
PHST- 2020/03/05 06:00 [pubmed]
PHST- 2020/03/05 06:01 [medline]
PHST- 2020/02/25 00:00 [pmc-release]
AID - S1939-4551(19)31236-0 [pii]
AID - 100080 [pii]
AID - 10.1016/j.waojou.2019.100080 [doi]
PST - epublish
SO  - World Allergy Organ J. 2020 Feb 25;13(2):100080. doi: 
      10.1016/j.waojou.2019.100080. eCollection 2020 Feb.