PMID- 32128921
OWN - NLM
STAT- MEDLINE
DCOM- 20210708
LR  - 20210708
IS  - 1099-1492 (Electronic)
IS  - 0952-3480 (Print)
IS  - 0952-3480 (Linking)
VI  - 33
IP  - 6
DP  - 2020 Jun
TI  - The relationship between liver triglyceride composition and proton density fat 
      fraction as assessed by (1) H MRS.
PG  - e4286
LID - 10.1002/nbm.4286 [doi]
AB  - The aim of this study was to estimate parameters determining liver triglyceride 
      composition (TC) using (1) H MRS and to assess how TC estimability is affected by 
      proton density fat fraction (PDFF) in adults with nonalcoholic fatty liver 
      disease (NAFLD). In this prospective single-site study, 199 adults with known or 
      suspected NAFLD in whom other causes of liver disease were excluded underwent two 
      (1) H MRS STimulated Echo Acquisition Method (STEAM) sequences at 3 T. A 
      respiratory-gated water-suppressed free breathing sequence (TE 10 ms, 16 signal 
      averages) was used to assess TC in terms of the number of double bonds (ndb) and 
      methylene-interrupted double bonds (nmidb), and a single breath-hold-long TR, 
      multi-TE sequence (TR 3500 ms), which acquired five single average spectra over 
      TE 10-30 ms, was used to estimate liver PDFF. Ndb and nmidb estimability was 
      qualitatively assessed for each case and summarized descriptively. The 
      consistency of ndb and nmidb estimation was examined using ROC analysis. The 
      relationship between ndb and nmidb values and PDFF was presented graphically. 
      Quality-of-fit of ndb and nmidb versus PDFF was evaluated by Pearson-r 
      correlation. A significance level of 0.05 was used. In 263 (1) H MRS examinations 
      performed on 199 adult participants, ndb and nmidb were successfully estimated in 
      7/53 (13.2%) examinations with PDFF < 4%, 13/30 (43.3%) examinations with PDFF 
      between 4% and 7%, 33/41 (80.5%) examinations with PDFF between 7% and 10%, and 
      124/139 (89.2%) examinations with PDFF > 10% (maximum PDFF 38.1%). Liver TC could 
      be estimated consistently for PDFF > 6.7%. Both ndb and nmidb decreased with 
      increasing PDFF (ndb = 2.83-0.0160.PDFF, r = -0.449, P < 0.0001); nmidb = 
      0.75-0.0088.PDFF, r = -0.350, P < 0.0001). In a cohort of adults with known or 
      suspected NAFLD, liver TC becomes more saturated as PDFF increases.
CI  - (c) 2020 John Wiley & Sons, Ltd.
FAU - Hamilton, Gavin
AU  - Hamilton G
AUID- ORCID: 0000-0001-9302-5546
AD  - Liver Imaging Group, Department of Radiology, University of California San Diego, 
      La Jolla, California.
FAU - Schlein, Alex N
AU  - Schlein AN
AD  - Liver Imaging Group, Department of Radiology, University of California San Diego, 
      La Jolla, California.
FAU - Wolfson, Tanya
AU  - Wolfson T
AD  - Computational and Applied Statistic Laboratory, San Diego Supercomputing Center, 
      University of California San Diego, San Diego, California.
FAU - Cunha, Guilherme M
AU  - Cunha GM
AD  - Liver Imaging Group, Department of Radiology, University of California San Diego, 
      La Jolla, California.
FAU - Fowler, Kathryn J
AU  - Fowler KJ
AD  - Liver Imaging Group, Department of Radiology, University of California San Diego, 
      La Jolla, California.
FAU - Middleton, Michael S
AU  - Middleton MS
AD  - Liver Imaging Group, Department of Radiology, University of California San Diego, 
      La Jolla, California.
FAU - Loomba, Rohit
AU  - Loomba R
AD  - Division of Epidemiology, Department of Family Medicine and Public Health, 
      University of California San Diego, La Jolla, California.
AD  - NAFLD Research Center, Division of Gastroenterology, Department of Medicine, 
      University of California San Diego, La Jolla, California.
FAU - Sirlin, Claude B
AU  - Sirlin CB
AD  - Liver Imaging Group, Department of Radiology, University of California San Diego, 
      La Jolla, California.
LA  - eng
GR  - R01 DK088925/DK/NIDDK NIH HHS/United States
GR  - R01 DK075128/DK/NIDDK NIH HHS/United States
GR  - R56 DK090350/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20200303
PL  - England
TA  - NMR Biomed
JT  - NMR in biomedicine
JID - 8915233
RN  - 0 (Protons)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Liver/*diagnostic imaging/*metabolism
MH  - Male
MH  - Middle Aged
MH  - *Proton Magnetic Resonance Spectroscopy
MH  - *Protons
MH  - ROC Curve
MH  - Triglycerides/*metabolism
MH  - Young Adult
PMC - PMC7211117
MID - NIHMS1571439
OTO - NOTNLM
OT  - fatty acids
OT  - hepatic triglyceride saturation
OT  - magnetic resonance spectroscopy
OT  - nonalcoholic fatty liver disease
OT  - nonalcoholic steatohepatitis
OT  - proton density fat fraction
OT  - triglyceride composition
EDAT- 2020/03/05 06:00
MHDA- 2021/07/09 06:00
PMCR- 2021/06/01
CRDT- 2020/03/05 06:00
PHST- 2019/07/03 00:00 [received]
PHST- 2020/02/11 00:00 [revised]
PHST- 2020/02/12 00:00 [accepted]
PHST- 2020/03/05 06:00 [pubmed]
PHST- 2021/07/09 06:00 [medline]
PHST- 2020/03/05 06:00 [entrez]
PHST- 2021/06/01 00:00 [pmc-release]
AID - 10.1002/nbm.4286 [doi]
PST - ppublish
SO  - NMR Biomed. 2020 Jun;33(6):e4286. doi: 10.1002/nbm.4286. Epub 2020 Mar 3.