PMID- 32129011
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 2192-2659 (Electronic)
IS  - 2192-2640 (Linking)
VI  - 9
IP  - 7
DP  - 2020 Apr
TI  - A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue.
PG  - e1901697
LID - 10.1002/adhm.201901697 [doi]
AB  - A needle-type microrobot (MR) for targeted drug delivery is developed to stably 
      deliver drugs to a target microtissue (MT) for a given period time without the 
      need for an external force after affixing. The MRs are fabricatedby 3D laser 
      lithography and nickel (Ni)/titanium oxide (TiO(2) ) layers are coated by 
      physical vapor deposition. The translational velocity of the MR is 714 microm s(-1) 
      at 20 mT and affixed to the target MT under the control of a rotating magnetic 
      field. The manipulability of the MR is shown by using both manual and automatic 
      controls. Finally, drug release from the paclitaxel-loaded MR is characterized to 
      determine the efficiency of targeted drug delivery. This study demonstrates the 
      utility of the proposed needle-type MR for targeted drug delivery to MT with 
      various flow rates in vitro physiological fluidic environments.
CI  - (c) 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Lee, Seungmin
AU  - Lee S
AD  - Department of Robotics Engineering, DGIST-ETH Microrobot Research Center, 
      Daegu-Gyeongbuk Institute of Science & Technology (DGIST), 333 Techno 
      jungang-daero, Hyeonpung-eup, Dalseong-Gun, Daegu, 42988, Republic of Korea.
FAU - Kim, Jin-Young
AU  - Kim JY
AD  - Department of Robotics Engineering, DGIST-ETH Microrobot Research Center, 
      Daegu-Gyeongbuk Institute of Science & Technology (DGIST), 333 Techno 
      jungang-daero, Hyeonpung-eup, Dalseong-Gun, Daegu, 42988, Republic of Korea.
FAU - Kim, Junyoung
AU  - Kim J
AD  - Department of Robotics Engineering, DGIST-ETH Microrobot Research Center, 
      Daegu-Gyeongbuk Institute of Science & Technology (DGIST), 333 Techno 
      jungang-daero, Hyeonpung-eup, Dalseong-Gun, Daegu, 42988, Republic of Korea.
FAU - Hoshiar, Ali Kafash
AU  - Hoshiar AK
AD  - School of Computer Science and Electronic Engineering, University of Essex, 
      Colchester, CO4 3SQ, UK.
FAU - Park, Jongeon
AU  - Park J
AD  - Department of Robotics Engineering, DGIST-ETH Microrobot Research Center, 
      Daegu-Gyeongbuk Institute of Science & Technology (DGIST), 333 Techno 
      jungang-daero, Hyeonpung-eup, Dalseong-Gun, Daegu, 42988, Republic of Korea.
FAU - Lee, Sunkey
AU  - Lee S
AD  - Department of Robotics Engineering, DGIST-ETH Microrobot Research Center, 
      Daegu-Gyeongbuk Institute of Science & Technology (DGIST), 333 Techno 
      jungang-daero, Hyeonpung-eup, Dalseong-Gun, Daegu, 42988, Republic of Korea.
FAU - Kim, Jonghyun
AU  - Kim J
AD  - School of Mechanical Engineering, Sungkyunkwan University, 2066 Seobu-ro, 
      Jangan-gu, Suwon-si, Gyeonggi-do, 16419, South Korea.
FAU - Pane, Salvador
AU  - Pane S
AD  - Institute of Robotics and Intelligent Systems, ETH Zurich, Zurich, CH-8092, 
      Switzerland.
FAU - Nelson, Bradley J
AU  - Nelson BJ
AD  - Institute of Robotics and Intelligent Systems, ETH Zurich, Zurich, CH-8092, 
      Switzerland.
FAU - Choi, Hongsoo
AU  - Choi H
AUID- ORCID: 0000-0003-3613-2833
AD  - Department of Robotics Engineering, DGIST-ETH Microrobot Research Center, 
      Daegu-Gyeongbuk Institute of Science & Technology (DGIST), 333 Techno 
      jungang-daero, Hyeonpung-eup, Dalseong-Gun, Daegu, 42988, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200303
PL  - Germany
TA  - Adv Healthc Mater
JT  - Advanced healthcare materials
JID - 101581613
RN  - 0 (Pharmaceutical Preparations)
RN  - P88XT4IS4D (Paclitaxel)
SB  - IM
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Needles
MH  - Paclitaxel
MH  - *Pharmaceutical Preparations
OTO - NOTNLM
OT  - drug delivery
OT  - fixation
OT  - magnetic manipulation
OT  - microrobots
OT  - targeted drug delivery
EDAT- 2020/03/05 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/03/05 06:00
PHST- 2019/11/26 00:00 [received]
PHST- 2020/02/10 00:00 [revised]
PHST- 2020/03/05 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/03/05 06:00 [entrez]
AID - 10.1002/adhm.201901697 [doi]
PST - ppublish
SO  - Adv Healthc Mater. 2020 Apr;9(7):e1901697. doi: 10.1002/adhm.201901697. Epub 2020 
      Mar 3.