PMID- 32130717
OWN - NLM
STAT- MEDLINE
DCOM- 20211004
LR  - 20211004
IS  - 1920-7476 (Electronic)
IS  - 0008-4263 (Print)
IS  - 0008-4263 (Linking)
VI  - 111
IP  - 5
DP  - 2020 Oct
TI  - Association between C-reactive protein and mood disorder in a representative 
      sample of the Canadian population: analysis of CHMS data 2013-2014.
PG  - 743-751
LID - 10.17269/s41997-020-00297-3 [doi]
AB  - OBJECTIVES: The inflammatory biomarker C-reactive protein (CRP) measures systemic 
      inflammation and has been shown to be increased in patients with mood disorders 
      such as depression. The objective of this study was to determine the association 
      between self-reported mood disorders with CRP levels in a representative sample 
      of the Canadian population using the Canadian Health Measures Survey (CHMS) data 
      2013-2014. METHODS: The CHMS is an ongoing national cross-sectional survey of 
      Canadians about their general health. The current study used the data collected 
      from Cycle 3 (2012/13) and was limited to adults aged 18 and older. Survey 
      weights were assigned to adjust for non-response and non-random sample selection 
      of the responding sample. RESULTS: Data were analyzed from 5782 respondents (400 
      (6.9%) self-reported mood disorders and 5382 (93.1%) reported no mood disorders). 
      The CRP level was significantly higher among those with mood disorders than 
      among those without (3.22 (0.17) vs. 2.34 (0.04) mg/L, p = 0.003). Respondents 
      with CRP levels > 10.00 mg/L had 2.69 greater odds of reporting a mood disorder 
      compared with those with CRP levels </= 1.00 mg/L (p = 0.02). Higher proportions of 
      respondents with mood disorders were older, had lower BMI, had secondary 
      education, had weak sense of community, had higher proportion of asthma or 
      arthritis, were current/past smokers, had daily consumption of 3+ drinks of 
      alcohol, and used prescription drugs, cannabis/hashish, or other drugs compared 
      with those without mood disorders (all p's < 0.05). CONCLUSION: This study 
      supported the association of CRP and mood disorder, specifically in a 
      representative sample of the Canadian population. Targeting inflammation in 
      depression and mood disorder warrants further study.
FAU - Leung, Brenda M Y
AU  - Leung BMY
AUID- ORCID: 0000-0002-4699-8086
AD  - Faculty of Health Sciences, University of Lethbridge, 4401 University Drive, 
      Lethbridge, AB, T1K 3M4, Canada. Brenda.leung@uleth.ca.
FAU - Nwoke, Chinenye
AU  - Nwoke C
AD  - Faculty of Health Sciences, University of Lethbridge, 4401 University Drive, 
      Lethbridge, AB, T1K 3M4, Canada.
LA  - eng
PT  - Journal Article
DEP - 20200304
PL  - Switzerland
TA  - Can J Public Health
JT  - Canadian journal of public health = Revue canadienne de sante publique
JID - 0372714
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - *C-Reactive Protein/metabolism
MH  - Canada/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Health Surveys
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mood Disorders/blood/epidemiology
PMC - PMC7501392
OTO - NOTNLM
OT  - Biomarker
OT  - CRP
OT  - Depression
OT  - Inflammation
OT  - Mood disorder
EDAT- 2020/03/05 06:00
MHDA- 2021/10/05 06:00
PMCR- 2021/03/04
CRDT- 2020/03/05 06:00
PHST- 2019/09/17 00:00 [received]
PHST- 2020/02/04 00:00 [accepted]
PHST- 2020/03/05 06:00 [pubmed]
PHST- 2021/10/05 06:00 [medline]
PHST- 2020/03/05 06:00 [entrez]
PHST- 2021/03/04 00:00 [pmc-release]
AID - 10.17269/s41997-020-00297-3 [pii]
AID - 297 [pii]
AID - 10.17269/s41997-020-00297-3 [doi]
PST - ppublish
SO  - Can J Public Health. 2020 Oct;111(5):743-751. doi: 10.17269/s41997-020-00297-3. 
      Epub 2020 Mar 4.