PMID- 32130979
OWN - NLM
STAT- MEDLINE
DCOM- 20210329
LR  - 20210329
IS  - 1096-1208 (Electronic)
IS  - 0882-4010 (Linking)
VI  - 143
DP  - 2020 Jun
TI  - TNF-alpha polymorphisms might influence predisposition to periodontitis: A 
      meta-analysis.
PG  - 104113
LID - S0882-4010(20)30151-0 [pii]
LID - 10.1016/j.micpath.2020.104113 [doi]
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) polymorphisms might influence 
      predisposition to periodontitis, but the results of already published studies 
      were still controversial and ambiguous. So the authors designed this 
      meta-analysis to more precisely estimate relationship between TNF-alpha polymorphisms 
      and periodontitis by pooling the results of already published related studies. 
      METHODS: The authors searched Pubmed, Embase, Web of Science and CNKI for already 
      published studies. Forty-five already published studies were pooled analyzed in 
      this meta-analysis. RESULTS: The crude pooled meta-analyses results showed that 
      distributions of TNF-alpha rs361525, rs1800629, rs1800630 and rs1799964 polymorphisms 
      among patients and controls differed significantly, which suggested that these 
      polymorphisms might influence predisposition to periodontitis in the general 
      population. We also got similar significant results for rs361525, rs1800629, 
      rs1800630 and rs1799964 polymorphisms in subgroup analyses in Asians. The crude 
      findings were further subjected to Bonferroni correction to account for multiple 
      comparisons. For rs361525, rs1800629 and rs1799964 polymorphisms, basically no 
      changes of results were detected. But for rs1800630 polymorphism, the results 
      were no longer significant after adjustment for multiple comparisons. 
      CONCLUSIONS: This meta-analysis suggested that TNF-alpha rs361525, rs1800629 and 
      rs1799964 polymorphisms might influence predisposition to periodontitis, 
      particularly in Asians.
CI  - Published by Elsevier Ltd.
FAU - Li, Ying
AU  - Li Y
AD  - Department of Stomatology, Lishui Central Hospital of Zhejiang Province, Lishui, 
      323000, Zhejiang, China. Electronic address: liyingdhusf@163.com.
FAU - Yang, Jie
AU  - Yang J
AD  - Department of Infectious Diseases, Lishui Central Hospital of Zhejiang Province, 
      Lishui, 323000, Zhejiang, China. Electronic address: yangjieshus@126.com.
FAU - Wu, Xiaoyan
AU  - Wu X
AD  - Department of Radiotherapy, Lishui Municipal Central Hospital, Lishui, 323000, 
      Zhejiang, China. Electronic address: wuyxiaogyanf@163.com.
FAU - Sun, Weifeng
AU  - Sun W
AD  - School of Medicine and Health Sciences, Lishui University, Lishui, 323000, 
      Zhejiang, China. Electronic address: sunfeishwzi@126.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20200301
PL  - England
TA  - Microb Pathog
JT  - Microbial pathogenesis
JID - 8606191
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - Periodontitis/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
OTO - NOTNLM
OT  - Asians
OT  - Meta-analysis
OT  - Periodontitis
OT  - Polymorphisms
OT  - Tumor necrosis factor-alpha (TNF-alpha)
COIS- Declaration of competing interest The authors declare that they have no conflict 
      of interest.
EDAT- 2020/03/05 06:00
MHDA- 2021/03/30 06:00
CRDT- 2020/03/05 06:00
PHST- 2020/01/28 00:00 [received]
PHST- 2020/02/24 00:00 [revised]
PHST- 2020/02/28 00:00 [accepted]
PHST- 2020/03/05 06:00 [pubmed]
PHST- 2021/03/30 06:00 [medline]
PHST- 2020/03/05 06:00 [entrez]
AID - S0882-4010(20)30151-0 [pii]
AID - 10.1016/j.micpath.2020.104113 [doi]
PST - ppublish
SO  - Microb Pathog. 2020 Jun;143:104113. doi: 10.1016/j.micpath.2020.104113. Epub 2020 
      Mar 1.