PMID- 32131113
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 129
IP  - 10
DP  - 2021 Oct
TI  - Carotid Intima-Media Thickness is a Predictor of Subclinical Myocardial Damage in 
      Men with Type 2 Diabetes Mellitus.
PG  - 750-756
LID - 10.1055/a-1107-2657 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) promotes the development of 
      atherosclerosis and is a major risk factor for cardiovascular disease. 
      High-sensitivity cardiac troponin I (hs-cTnI) assays fundamentally improved the 
      diagnosis of myocardial injury and even enable the prediction of future 
      cardiovascular events in the general population. However, data about the 
      association of hs-cTnI with cardiovascular risk factors and carotid intima media 
      thickness (cIMT) as a marker of atherosclerosis are limited, especially in 
      patients with T2DM. METHODS: In this cross-sectional study we analyzed clinical 
      and laboratory parameters of 234 patients (43% women) with T2DM and a median age 
      of 65 years (interquartile range: 57-71). The median duration of diabetes 
      mellitus was 10 years (6-17). Anthropometric data, blood pressure, glycemic 
      parameters and lipid profiles were determined. Hs-cTnI plasma concentrations were 
      measured on an ADVIA Centaur XPT immunoassay analyzer and cIMT was evaluated by 
      high-resolution ultrasound. RESULTS: Hs-cTnI plasma concentrations were below the 
      gender-specific 99(th)  percentile in 93% of T2DM patients with a median 
      concentration of 4.0 ng/l (interquartile range: 2.0-10.0). Hs-cTnI was 
      significantly associated with gender, renal function and C-reactive protein in 
      the entire study cohort. Gender-specific analyses revealed cIMT and renal 
      function to be significantly associated with hs-cTnI in men. Contrary, only age 
      was significantly associated with hs-cTnI in women. CONCLUSION: In a real-world 
      clinical setting in patients with T2DM, cIMT is a predictor of subclinical 
      myocardial damage in men, but not in women.
CI  - Georg Thieme Verlag KG Rudigerstrasse 14, 70469 Stuttgart, Germany.
FAU - Horber, Sebastian
AU  - Horber S
AD  - Department for Diagnostic Laboratory Medicine, Institute for Clinical Chemistry 
      and Pathobiochemistry, University Hospital Tubingen, Germany.
AD  - Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center 
      Munich at the University of Tubingen, Germany.
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
FAU - Lehn-Stefan, Angela
AU  - Lehn-Stefan A
AD  - Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center 
      Munich at the University of Tubingen, Germany.
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
FAU - Hieronimus, Anja
AU  - Hieronimus A
AD  - Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center 
      Munich at the University of Tubingen, Germany.
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
AD  - Department of Internal Medicine IV, Division of Endocrinology and Diabetology, 
      Nephrology University Hospital of Tubingen, Germany.
FAU - Hudak, Sarah
AU  - Hudak S
AD  - Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center 
      Munich at the University of Tubingen, Germany.
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
AD  - Department of Internal Medicine IV, Division of Endocrinology and Diabetology, 
      Nephrology University Hospital of Tubingen, Germany.
FAU - Fritsche, Louise
AU  - Fritsche L
AD  - Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center 
      Munich at the University of Tubingen, Germany.
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
AD  - Department of Internal Medicine IV, Division of Endocrinology and Diabetology, 
      Nephrology University Hospital of Tubingen, Germany.
FAU - Fritsche, Andreas
AU  - Fritsche A
AUID- ORCID: 0000-0002-4987-1961
AD  - Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center 
      Munich at the University of Tubingen, Germany.
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
AD  - Department of Internal Medicine IV, Division of Endocrinology and Diabetology, 
      Nephrology University Hospital of Tubingen, Germany.
FAU - Heni, Martin
AU  - Heni M
AD  - Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center 
      Munich at the University of Tubingen, Germany.
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
AD  - Department of Internal Medicine IV, Division of Endocrinology and Diabetology, 
      Nephrology University Hospital of Tubingen, Germany.
FAU - Haring, Hans-Ulrich
AU  - Haring HU
AD  - Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center 
      Munich at the University of Tubingen, Germany.
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
AD  - Department of Internal Medicine IV, Division of Endocrinology and Diabetology, 
      Nephrology University Hospital of Tubingen, Germany.
FAU - Peter, Andreas
AU  - Peter A
AD  - Department for Diagnostic Laboratory Medicine, Institute for Clinical Chemistry 
      and Pathobiochemistry, University Hospital Tubingen, Germany.
AD  - Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center 
      Munich at the University of Tubingen, Germany.
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
FAU - Randrianarisoa, Elko
AU  - Randrianarisoa E
AD  - Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center 
      Munich at the University of Tubingen, Germany.
AD  - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200304
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Troponin I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Carotid Intima-Media Thickness
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Cardiomyopathies/blood/*diagnosis/etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Sex Factors
MH  - Troponin I/*blood
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/03/05 06:00
MHDA- 2022/02/01 06:00
CRDT- 2020/03/05 06:00
PHST- 2020/03/05 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2020/03/05 06:00 [entrez]
AID - 10.1055/a-1107-2657 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2021 Oct;129(10):750-756. doi: 10.1055/a-1107-2657. 
      Epub 2020 Mar 4.