PMID- 32131470
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2304-8158 (Print)
IS  - 2304-8158 (Electronic)
IS  - 2304-8158 (Linking)
VI  - 9
IP  - 3
DP  - 2020 Mar 2
TI  - Phytopharmacological Strategies in the Management of Type 2 Diabetes Mellitus.
LID - 10.3390/foods9030271 [doi]
LID - 271
AB  - Type 2 Diabetes Mellitus (T2DM) is a chronic disease which corresponds to 90% of 
      the worldwide cases of diabetes, mainly due to epigenetic factors such as 
      unhealthy lifestyles. First line therapeutic approaches are based on lifestyle 
      changes, most of the time complemented with medication mostly associated with 
      several side effects and high costs. As a result, the scientific community is 
      constantly working for the discovery and development of natural therapeutic 
      strategies that provide lower financial impact and minimize side effects. This 
      review focus on these nature-based therapeutic strategies for prevention and 
      control of T2DM, with a special emphasis on natural compounds that present 
      pharmacological activity as dipeptidyl peptidase-4 (DPP4), alpha-amylase, 
      alpha-glucosidase, lipase, and protein tyrosine phosphatase 1B (PTP1B) 
      inhibitors.
FAU - Duarte, Ana M
AU  - Duarte AM
AUID- ORCID: 0000-0001-7103-3924
AD  - MARE-Marine and Environmental Sciences Center, Politecnico de Leiria, 2520-630 
      Peniche, Portugal.
FAU - Guarino, Maria P
AU  - Guarino MP
AUID- ORCID: 0000-0001-6079-1105
AD  - ciTechCare-Center for Innovative Care and Health Technology, Politecnico de 
      Leiria, 2410-541 Leiria, Portugal.
FAU - Barroso, Sonia
AU  - Barroso S
AD  - MARE-Marine and Environmental Sciences Center, Politecnico de Leiria, 2520-630 
      Peniche, Portugal.
FAU - Gil, Maria M
AU  - Gil MM
AD  - MARE-Marine and Environmental Sciences Center, Politecnico de Leiria, 2520-630 
      Peniche, Portugal.
LA  - eng
GR  - UID/MAR/04292/2019/Fundacao para a Ciencia e a Tecnologia, Portugal/
PT  - Journal Article
PT  - Review
DEP - 20200302
PL  - Switzerland
TA  - Foods
JT  - Foods (Basel, Switzerland)
JID - 101670569
PMC - PMC7143818
OTO - NOTNLM
OT  - alpha-amylase
OT  - alpha-glucosidase
OT  - dipeptidyl peptidase-4 (DPP4)
OT  - lipase
OT  - phytopharmacology
OT  - protein tyrosine phosphatase 1B (PTP1B)
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2020/03/07 06:00
MHDA- 2020/03/07 06:01
PMCR- 2020/03/02
CRDT- 2020/03/06 06:00
PHST- 2020/02/03 00:00 [received]
PHST- 2020/02/19 00:00 [revised]
PHST- 2020/02/25 00:00 [accepted]
PHST- 2020/03/06 06:00 [entrez]
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2020/03/07 06:01 [medline]
PHST- 2020/03/02 00:00 [pmc-release]
AID - foods9030271 [pii]
AID - foods-09-00271 [pii]
AID - 10.3390/foods9030271 [doi]
PST - epublish
SO  - Foods. 2020 Mar 2;9(3):271. doi: 10.3390/foods9030271.