PMID- 32132811
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210302
IS  - 1061-1711 (Print)
IS  - 1615-5939 (Electronic)
IS  - 1061-1711 (Linking)
VI  - 29
IP  - 1
DP  - 2020 Mar
TI  - Factors Affecting Mortality in Patients with Blood-Culture Negative Infective 
      Endocarditis.
PG  - 12-18
LID - 10.1055/s-0039-3402744 [doi]
AB  - Infective endocarditis retains high morbidity and mortality rates despite recent 
      advances in diagnostics, pharmacotherapy, and surgical intervention. Risk 
      stratification in endocarditis patients, including blood-culture negative 
      endocarditis, is crucial in deciding the optimal management strategy; however, 
      the studies investigating risk stratification in these patients were lacking 
      despite the difference with blood-culture positive endocarditis. The aim of this 
      study is to identify risk factors associated with in-hospital mortality in 
      blood-culture negative infective endocarditis patients. A retrospective cohort 
      study was conducted at National Cardiovascular Center Harapan Kita, Jakarta in 
      blood-culture negative infective endocarditis patients from 2013 to 2015. Patient 
      characteristics, clinical parameters, echocardiographic parameters, and clinical 
      complications were collected from medical records and hospital information 
      systems. There were 146 patients that satisfy the inclusion and exclusion 
      criteria out of 162 patients with blood-culture infective endocarditis. The 
      in-hospital mortality rate was 13.5%. On bivariate analyses, factors that were 
      related to in-hospital mortality include New York Heart Association (NYHA) class 
      III and IV heart failure ( p  = 0.007), history of hypertension ( p  = 0.021), 
      stroke during hospitalization ( p  < 0.001), the decline in renal function ( p 
       < 0.001), and surgery ( p  = 0.028). Variables that were independently 
      associated with mortality upon multivariate analysis were heart failure NYHA 
      functional class III and IV (OR 7.56, p  = 0.011), worsening kidney function (OR 
      10.23, p  < 0.001), and stroke during hospitalization (OR 8.92, p  = 0.001). 
      Presence of heart failure with NYHA functional class III and IV, worsening kidney 
      function, and stroke during hospitalization were independently associated with 
      in-hospital mortality in blood-culture infective endocarditis patients.
CI  - (c) Thieme Medical Publishers.
FAU - Firiana, Lira
AU  - Firiana L
AD  - Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas 
      Indonesia, National Cardiovascular Center Harapan Kita, Jakarta.
FAU - Siswanto, Bambang Budi
AU  - Siswanto BB
AUID- ORCID: 0000-0003-3998-1590
AD  - Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas 
      Indonesia, National Cardiovascular Center Harapan Kita, Jakarta.
FAU - Yonas, Emir
AU  - Yonas E
AUID- ORCID: 0000-0002-8604-405X
AD  - Faculty of Medicine, Universitas Yarsi, Jakarta, Indonesia.
FAU - Prakoso, Radityo
AU  - Prakoso R
AD  - Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas 
      Indonesia, National Cardiovascular Center Harapan Kita, Jakarta.
FAU - Pranata, Raymond
AU  - Pranata R
AUID- ORCID: 0000-0003-3998-6551
AD  - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20200204
PL  - United States
TA  - Int J Angiol
JT  - The International journal of angiology : official publication of the 
      International College of Angiology, Inc
JID - 9504821
PMC - PMC7054058
OTO - NOTNLM
OT  - blood-culture negative infective endocarditis
OT  - heart failure
OT  - mortality
OT  - renal function
COIS- Conflicts of Interest None.
EDAT- 2020/03/07 06:00
MHDA- 2020/03/07 06:01
PMCR- 2021/03/01
CRDT- 2020/03/06 06:00
PHST- 2020/03/06 06:00 [entrez]
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2020/03/07 06:01 [medline]
PHST- 2021/03/01 00:00 [pmc-release]
AID - 190063 [pii]
AID - 10.1055/s-0039-3402744 [doi]
PST - ppublish
SO  - Int J Angiol. 2020 Mar;29(1):12-18. doi: 10.1055/s-0039-3402744. Epub 2020 Feb 4.