PMID- 32132993
OWN - NLM
STAT- MEDLINE
DCOM- 20210308
LR  - 20210308
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 11
DP  - 2020
TI  - Wnt Signaling Cascade in Dendritic Cells and Regulation of Anti-tumor Immunity.
PG  - 122
LID - 10.3389/fimmu.2020.00122 [doi]
LID - 122
AB  - Dendritic cells (DCs) control the strength and quality of antigen-specific 
      adaptive immune responses. This is critical for launching a robust immunity 
      against invading pathogens while maintaining a state of tolerance to 
      self-antigens. However, this also represents a fundamental barrier to anti-tumor 
      immune responses and cancer immunotherapy. DCs in the tumor microenvironment 
      (TME) play a key role in this process. The factors in the TME and signaling 
      networks that program DCs to a regulatory state are not fully understood. Recent 
      advances point to novel mechanisms by which the canonical Wnt signaling cascade 
      in DCs regulates immune suppression, and the same pathway in tumors is associated 
      with the evasion of anti-tumor immunity. Here, we review these recent advances in 
      the context of the pleiotropic effects of the Wnts in shaping anti-tumor immune 
      responses by modulating DC functions. In addition, we will discuss how 
      Wnt/beta-catenin pathway in DCs can be targeted for successful cancer immunotherapy.
CI  - Copyright (c) 2020 Suryawanshi, Hussein, Prasad and Manicassamy.
FAU - Suryawanshi, Amol
AU  - Suryawanshi A
AD  - Department of Pathobiology, College of Veterinary Medicine, Auburn University, 
      Auburn, AL, United States.
FAU - Hussein, Mohamed S
AU  - Hussein MS
AD  - Georgia Cancer Center, Augusta University, Augusta, GA, United States.
FAU - Prasad, Puttur D
AU  - Prasad PD
AD  - Department of Biochemistry and Molecular Biology, Medical College of Georgia, 
      Augusta University, Augusta, GA, United States.
FAU - Manicassamy, Santhakumar
AU  - Manicassamy S
AD  - Georgia Cancer Center, Augusta University, Augusta, GA, United States.
AD  - Department of Biochemistry and Molecular Biology, Medical College of Georgia, 
      Augusta University, Augusta, GA, United States.
AD  - Department of Medicine, Medical College of Georgia, Augusta University, Augusta, 
      GA, United States.
LA  - eng
GR  - R01 DK097271/DK/NIDDK NIH HHS/United States
GR  - R01 DK123360/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200217
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (beta Catenin)
SB  - IM
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Humans
MH  - Immunity/*immunology
MH  - Immunotherapy
MH  - Neoplasms/immunology
MH  - Signal Transduction/immunology
MH  - Tumor Microenvironment/*immunology/*physiology
MH  - Wnt Signaling Pathway/*immunology
MH  - beta Catenin/immunology/metabolism
PMC - PMC7039855
OTO - NOTNLM
OT  - Wnt
OT  - anti-tumor immunity
OT  - beta-catenin (beta-catenin)
OT  - dendritic cells
OT  - immunotherapy
OT  - tumor microenvironment (TME)
EDAT- 2020/03/07 06:00
MHDA- 2021/03/09 06:00
PMCR- 2020/01/01
CRDT- 2020/03/06 06:00
PHST- 2019/06/10 00:00 [received]
PHST- 2020/01/16 00:00 [accepted]
PHST- 2020/03/06 06:00 [entrez]
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2021/03/09 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2020.00122 [doi]
PST - epublish
SO  - Front Immunol. 2020 Feb 17;11:122. doi: 10.3389/fimmu.2020.00122. eCollection 
      2020.