PMID- 32133014
OWN - NLM
STAT- MEDLINE
DCOM- 20210325
LR  - 20210325
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 11
DP  - 2020
TI  - TRIM59 Protects Mice From Sepsis by Regulating Inflammation and Phagocytosis in 
      Macrophages.
PG  - 263
LID - 10.3389/fimmu.2020.00263 [doi]
LID - 263
AB  - Sepsis is associated with bacterial invasion and inflammation and has a high 
      mortality rate. Previous studies have demonstrated that tripartite motif 59 
      (TRIM59) was involved in NF-kappaB signaling and could promote phagocytosis of 
      macrophages, but the role of TRIM59 in sepsis is still unknown. In our study, we 
      found that TRIM59 was downregulated in lipopolysaccharide (LPS)-stimulated bone 
      marrow-derived macrophages (BMDMs). In the cecal ligation and puncture (CLP) 
      sepsis mice model, the mortality of Trim59(flox/flox)Lyz-Cre (Trim59-cKO) mice 
      was higher, the immune cell infiltration and damage of liver and lung were more 
      severe, and bacteria burden was increased. We also found that TRIM59 altered the 
      production of pro-inflammation cytokines, as well as macrophage phagocytosis 
      ability. Further analysis indicated that NF-kappaB signal pathway and Fcgamma receptors 
      might be involved in these regulations. Our study demonstrated for the first time 
      that TRIM59 protects mice from sepsis by regulating inflammation and phagocytosis 
      in macrophages.
CI  - Copyright (c) 2020 Jin, Zhu, Liu, Hou, Tang, Zhu, Tian, Li, Yan and Zhu.
FAU - Jin, Zheng
AU  - Jin Z
AD  - Department of Immunology, College of Basic Medical Sciences, Jilin University, 
      Changchun, China.
FAU - Zhu, Zhenhua
AU  - Zhu Z
AD  - Department of Orthopaedic Trauma, The First Hospital of Jilin University, 
      Changchun, China.
FAU - Liu, Shanshan
AU  - Liu S
AD  - Department of Immunology, College of Basic Medical Sciences, Jilin University, 
      Changchun, China.
FAU - Hou, Yuyang
AU  - Hou Y
AD  - Department of Immunology, College of Basic Medical Sciences, Jilin University, 
      Changchun, China.
FAU - Tang, Mengyan
AU  - Tang M
AD  - Department of Immunology, College of Basic Medical Sciences, Jilin University, 
      Changchun, China.
FAU - Zhu, Pei
AU  - Zhu P
AD  - Department of Immunology, College of Basic Medical Sciences, Jilin University, 
      Changchun, China.
FAU - Tian, Yuan
AU  - Tian Y
AD  - Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, 
      Jilin University, Changchun, China.
FAU - Li, Dong
AU  - Li D
AD  - Department of Immunology, College of Basic Medical Sciences, Jilin University, 
      Changchun, China.
FAU - Yan, Dongmei
AU  - Yan D
AD  - Department of Immunology, College of Basic Medical Sciences, Jilin University, 
      Changchun, China.
FAU - Zhu, Xun
AU  - Zhu X
AD  - Department of Immunology, College of Basic Medical Sciences, Jilin University, 
      Changchun, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200218
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Cytokines)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Receptors, IgG)
RN  - 0 (Trim59 protein, mouse)
RN  - 0 (Tripartite Motif Proteins)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Cytokines/biosynthesis
MH  - Inflammation/*prevention & control
MH  - Intracellular Signaling Peptides and Proteins/*physiology
MH  - Macrophages/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - NF-kappa B/physiology
MH  - Neutrophil Infiltration
MH  - *Phagocytosis
MH  - Receptors, IgG/analysis
MH  - Sepsis/*immunology
MH  - Signal Transduction/physiology
MH  - Tripartite Motif Proteins/*physiology
PMC - PMC7041419
OTO - NOTNLM
OT  - TRIM59
OT  - inflammation
OT  - macrophages
OT  - phagocytosis
OT  - sepsis
EDAT- 2020/03/07 06:00
MHDA- 2021/03/26 06:00
PMCR- 2020/01/01
CRDT- 2020/03/06 06:00
PHST- 2019/11/08 00:00 [received]
PHST- 2020/01/31 00:00 [accepted]
PHST- 2020/03/06 06:00 [entrez]
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2021/03/26 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2020.00263 [doi]
PST - epublish
SO  - Front Immunol. 2020 Feb 18;11:263. doi: 10.3389/fimmu.2020.00263. eCollection 
      2020.