PMID- 32133237
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2156-7085 (Print)
IS  - 2156-7085 (Electronic)
IS  - 2156-7085 (Linking)
VI  - 11
IP  - 2
DP  - 2020 Feb 1
TI  - Raman spectroscopy combined with multivariate analysis to study the biochemical 
      mechanism of lung cancer microwave ablation.
PG  - 1061-1072
LID - 10.1364/BOE.383869 [doi]
AB  - Lung cancer is the leading cause of death in cancer patients, and microwave 
      ablation (MWA) has been extensively used in clinical treatment. In this study, we 
      characterized the spectra of MWA-treated and untreated lung squamous cell 
      carcinoma (LSCC) tissues, as well as healthy lung tissue, and conducted a 
      preliminary analysis of spectral variations associated with MWA treatment. The 
      results of characteristic spectral analysis of different types of tissues 
      indicated that MWA treatment induces an increase in the content of nucleic acids, 
      proteins, and lipid components in lung cancer tissues. The discriminant model 
      based on the principal component analysis - linear discriminant analysis 
      (PCA-LDA) algorithm together with leave-one-out cross validation (LOOCV) method 
      yield the sensitivities of 90%, 80%, and 96%, and specificities of 86.2%, 93.8%, 
      and 100% among untreated and MWA-treated cancerous tissue, and healthy lung 
      tissue, respectively. These results indicate that Raman spectroscopy combined 
      with multivariate analysis techniques can be used to explore the biochemical 
      response mechanism of cancerous tissue to MWA therapy.
CI  - (c) 2020 Optical Society of America under the terms of the OSA Open Access 
      Publishing Agreement.
FAU - Song, Dongliang
AU  - Song D
AD  - Institute of Photonics and Photon-Technology, Northwest University, Xi'an, 
      Shaanxi, 710069, China.
AD  - Department of physics, Northwest University, Xi'an, Shaanxi, 710069, China.
FAU - Yu, Fan
AU  - Yu F
AD  - Institute of Photonics and Photon-Technology, Northwest University, Xi'an, 
      Shaanxi, 710069, China.
FAU - Chen, Shilin
AU  - Chen S
AD  - Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu 
      Cancer Hospital, Nanjing, Jiangsu, 210009, China.
AD  - chenshilin@163.com.
FAU - Chen, Yishen
AU  - Chen Y
AD  - Institute of Photonics and Photon-Technology, Northwest University, Xi'an, 
      Shaanxi, 710069, China.
FAU - He, Qingli
AU  - He Q
AUID- ORCID: 0000-0002-7413-8411
AD  - Department of physics, Northwest University, Xi'an, Shaanxi, 710069, China.
FAU - Zhang, Zhe
AU  - Zhang Z
AD  - Department of Pathology, Nanjing Medical University Affiliated Cancer Hospital, 
      Jiangsu Cancer Hospital, Nanjing, Jiangsu, 210009, China.
FAU - Zhang, Jingyuan
AU  - Zhang J
AD  - Department of Pathology, Nanjing Medical University Affiliated Cancer Hospital, 
      Jiangsu Cancer Hospital, Nanjing, Jiangsu, 210009, China.
FAU - Wang, Shuang
AU  - Wang S
AUID- ORCID: 0000-0002-5558-4029
AD  - Institute of Photonics and Photon-Technology, Northwest University, Xi'an, 
      Shaanxi, 710069, China.
AD  - swang@nwu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200123
PL  - United States
TA  - Biomed Opt Express
JT  - Biomedical optics express
JID - 101540630
PMC - PMC7041477
COIS- The authors declare that there are no conflicts of interest related to this 
      article.
EDAT- 2020/03/07 06:00
MHDA- 2020/03/07 06:01
PMCR- 2020/02/01
CRDT- 2020/03/06 06:00
PHST- 2019/11/25 00:00 [received]
PHST- 2020/01/14 00:00 [revised]
PHST- 2020/01/15 00:00 [accepted]
PHST- 2020/03/06 06:00 [entrez]
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2020/03/07 06:01 [medline]
PHST- 2020/02/01 00:00 [pmc-release]
AID - 383869 [pii]
AID - 10.1364/BOE.383869 [doi]
PST - epublish
SO  - Biomed Opt Express. 2020 Jan 23;11(2):1061-1072. doi: 10.1364/BOE.383869. 
      eCollection 2020 Feb 1.