PMID- 32133587
OWN - NLM
STAT- MEDLINE
DCOM- 20210414
LR  - 20211103
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 30
IP  - 6
DP  - 2020 Jun
TI  - Impact of Postprandial Hypoglycemia on Weight Loss After Bariatric Surgery.
PG  - 2266-2273
LID - 10.1007/s11695-020-04465-9 [doi]
AB  - INTRODUCTION: Postprandial hypoglycemia (PPHG) is a well-known complication after 
      bariatric surgery (BS). However, it is not known whether PPHG affects weight loss 
      after BS. AIMS: To assess the impact of PPHG on weight loss after BS in subjects 
      without and with type 2 diabetes mellitus (T2D). METHODS: Data from 338 subjects 
      who had undergone gastric bypass (RYGB) or sleeve gastrectomy (LSG) and were 
      followed up for at least 2 years were analyzed. At each follow-up visit, the 
      patient's anthropometric and biochemical characteristics were recorded and the 
      Edinburgh Questionnaire was performed to evaluate the presence of PPHG symptoms. 
      RESULTS: Before surgery: younger age and lower BMI predicted PPHG after BS 
      (p = 0.02 and p = 0.0008, respectively). Also, the baseline OGTT indicated that 
      subjects who developed PPHG had an earlier glucose peak and more often had low 
      glucose levels at 2 h compared with the no-PPHG group (p = 0.03 and p = 0.004, 
      respectively). After surgery: Mild-to-moderate PPHG occurred equally after RYGB 
      and LSG (38% vs 25%, p = ns when accounting for confounders), and in T2D who 
      achieved remission and those who did not (29.5% vs 28.6%, ns). At the 2-year 
      follow-up, occurrence of PPHG was independently associated with smaller weight 
      loss (p = 0.0006). CONCLUSIONS: Mild-to-moderate PPHG is a frequent complication 
      after bariatric surgery and results in smaller weight loss after 2 years. Age, 
      baseline BMI, and an earlier glucose peak during OGTT predict PPHG after 
      bariatric surgery.
FAU - Rebelos, Eleni
AU  - Rebelos E
AUID- ORCID: 0000-0003-3050-8692
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy. eleni.rebelos@utu.fi.
FAU - Moriconi, Diego
AU  - Moriconi D
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Scalese, Marco
AU  - Scalese M
AD  - CNR Institute of Clinical Physiology, Pisa, Italy.
FAU - Denoth, Francesca
AU  - Denoth F
AD  - CNR Institute of Clinical Physiology, Pisa, Italy.
FAU - Molinaro, Sabrina
AU  - Molinaro S
AD  - CNR Institute of Clinical Physiology, Pisa, Italy.
FAU - Siciliano, Valeria
AU  - Siciliano V
AD  - CNR Institute of Clinical Physiology, Pisa, Italy.
FAU - Anselmino, Marco
AU  - Anselmino M
AD  - Unit of Bariatric Surgery, AOUP, Pisa, Italy.
FAU - Taddei, Stefano
AU  - Taddei S
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
FAU - Ferrannini, Ele
AU  - Ferrannini E
AD  - CNR Institute of Clinical Physiology, Pisa, Italy.
FAU - Nannipieri, Monica
AU  - Nannipieri M
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 
      Italy.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
SB  - IM
MH  - *Bariatric Surgery/adverse effects
MH  - *Diabetes Mellitus, Type 2/surgery
MH  - Gastrectomy/adverse effects
MH  - *Gastric Bypass/adverse effects
MH  - Humans
MH  - *Hypoglycemia/etiology
MH  - *Obesity, Morbid/surgery
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Weight Loss
OTO - NOTNLM
OT  - Bariatric surgery
OT  - Postprandial hypoglycemia
OT  - RYGB
OT  - Sleeve gastrectomy
OT  - Weight loss
EDAT- 2020/03/07 06:00
MHDA- 2021/04/15 06:00
CRDT- 2020/03/06 06:00
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2021/04/15 06:00 [medline]
PHST- 2020/03/06 06:00 [entrez]
AID - 10.1007/s11695-020-04465-9 [pii]
AID - 10.1007/s11695-020-04465-9 [doi]
PST - ppublish
SO  - Obes Surg. 2020 Jun;30(6):2266-2273. doi: 10.1007/s11695-020-04465-9.