PMID- 32134042
OWN - NLM
STAT- MEDLINE
DCOM- 20200831
LR  - 20220413
IS  - 1119-3077 (Print)
VI  - 23
IP  - 3
DP  - 2020 Mar
TI  - Warfarin therapy adherence and health-related quality of life among patients 
      using warfarin in Saudi Arabia.
PG  - 398-407
LID - 10.4103/njcp.njcp_608_18 [doi]
AB  - BACKGROUND: Treatment satisfaction and medication adherence to oral anticoagulant 
      therapy are important measures that often decrease morbidity and mortality. 
      Though warfarin is a frequently prescribed oral anticoagulant, warfarin therapy 
      adherence (WTA) and its impact on overall Health-Related Quality of Life (HRQoL) 
      has not been studied in Saudi Arabia. OBJECTIVES: To assess the association 
      between WTA and HRQoL among patients on warfarin in Saudi Arabia. METHODS: A 
      prospective, cross-sectional, descriptive study was conducted on 387 patients on 
      warfarin therapy attending an outpatient anticoagulation clinic in Alkharj, Saudi 
      Arabia. WTA was assessed using medication adherence measuring scale (MAMS) 
      whereas HRQoL was measured using World Health Organization QOL-BREF 
      (WHOQOL-BREF). Descriptive and inferential statistics were used to examine 
      patients' demographic characteristics and to determine the association among 
      different variables. Spearman's correlation coefficient was used to determine the 
      association between various study variables. RESULTS: Of the total 387 
      participants, there were more females than males (n=257, 66.4%, and n=130, 33.6% 
      respectively). The mean adherence score for the study population was 5.86+/-1.21. 
      Mean HRQoL score for physical health domain, psychological domain, social 
      relationships domain, and environment domain were 62.11+/-15.53, 68.20+/-16.11, 
      64.46+/-26.19 and 63.43+/-17.60 respectively. The correlation coefficients for all 
      the four domains of the WHOQOL-BREF vs total mean score of warfarin therapy 
      adherence were 0.124, 0.051, 0.063 and 0.083 respectively indicating a weak 
      positive association between warfarin therapy adherence and physical health 
      domain (P < 0.005). Study results indicate a positive association between WTA and 
      the physical health domain of the WHOQOL-BREF among patients on warfarin. 
      CONCLUSION: Better warfarin therapy adherence can improve the physical health of 
      patients on warfarin.
FAU - Al-Saikhan, F I
AU  - Al-Saikhan FI
AD  - Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz 
      University, Alkharj, Saudi Arabia.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Niger J Clin Pract
JT  - Nigerian journal of clinical practice
JID - 101150032
RN  - 0 (Anticoagulants)
RN  - 5Q7ZVV76EI (Warfarin)
SB  - IM
MH  - Anticoagulants/*therapeutic use
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Medication Adherence/*statistics & numerical data
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Saudi Arabia/epidemiology
MH  - Warfarin/*therapeutic use
OTO - NOTNLM
OT  - HRQOL
OT  - Saudi Arabia
OT  - WHOQOL-BREF
OT  - warfarin
OT  - warfarin therapy adherence
COIS- None
EDAT- 2020/03/07 06:00
MHDA- 2020/09/01 06:00
CRDT- 2020/03/06 06:00
PHST- 2020/03/06 06:00 [entrez]
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2020/09/01 06:00 [medline]
AID - NigerJClinPract_2020_23_3_398_280038 [pii]
AID - 10.4103/njcp.njcp_608_18 [doi]
PST - ppublish
SO  - Niger J Clin Pract. 2020 Mar;23(3):398-407. doi: 10.4103/njcp.njcp_608_18.