PMID- 3213425
OWN - NLM
STAT- MEDLINE
DCOM- 19890221
LR  - 20200304
IS  - 0001-6322 (Print)
IS  - 0001-6322 (Linking)
VI  - 76
IP  - 3
DP  - 1988
TI  - Nerve cell injury in the brain of stroke-prone spontaneously hypertensive rats.
PG  - 227-37
AB  - The brain lesions in stroke-prone spontaneously hypertensive rats (SHRSP) are 
      characterized by multifocal microvascular and spongy-cystic parenchymal 
      alterations particularly in the gray matter. An essential feature of the lesions 
      is the presence of edema with massive extravasation of plasma constituents as 
      evidenced by specific gravity measurements, Evans blue technique and 
      immunohistochemistry. The nerve cell injury occurring in the brain lesions in 
      SHRSP is further characterized by light and electron microscopy in the present 
      study. Two types of neuronal changes were seen within the blood-brain barrier 
      (BBB) leakage sites. A small number of neurons with dark condensed nucleus and 
      cytoplasm were found most often at the periphery of recent lesions. The majority 
      of injured neurons were pale and showed intracellular edema confined to the 
      dendrites and perikarya sparing axons and synapses. Their nuclei were well 
      preserved with finely dispersed chromatin. The swollen and watery cell processes 
      of neurons and astrocytes gave a spongy appearance to the neuropil. The 
      intracellular edema seemed to result in cytolysis. The results suggest that 
      primary anoxia-ischemia is not the major pathogenetic mechanism behind the nerve 
      cell injury in severely hypertensive SHRSP, rather it is the massive BBB leakage 
      and consequent brain edema that causes cytolytic destruction of neurons. 
      Secondary focal ischemia as a consequence of occlusion in microvessels may, 
      however, contribute to the nerve cell destruction.
FAU - Fredriksson, K
AU  - Fredriksson K
AD  - Department of Neurology, University Hospital, Lund, Sweden.
FAU - Kalimo, H
AU  - Kalimo H
FAU - Nordborg, C
AU  - Nordborg C
FAU - Johansson, B B
AU  - Johansson BB
FAU - Olsson, Y
AU  - Olsson Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Acta Neuropathol
JT  - Acta neuropathologica
JID - 0412041
RN  - 45PG892GO1 (Evans Blue)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier
MH  - Brain/*pathology
MH  - Cerebrovascular Disorders/*genetics/pathology
MH  - Evans Blue
MH  - Hypertension/*genetics/pathology
MH  - Immunohistochemistry
MH  - Male
MH  - Microscopy, Electron
MH  - Neurons/*pathology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred Strains
MH  - Rats, Inbred WKY
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1007/BF00687769 [doi]
PST - ppublish
SO  - Acta Neuropathol. 1988;76(3):227-37. doi: 10.1007/BF00687769.