PMID- 32134324
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20210528
IS  - 1752-0371 (Electronic)
IS  - 1752-0363 (Linking)
VI  - 14
IP  - 4
DP  - 2020 Mar
TI  - Mean corpuscular hemoglobin concentration correlates with prognosis of resected 
      hepatocellular carcinoma.
PG  - 259-270
LID - 10.2217/bmm-2019-0224 [doi]
AB  - Aim: To evaluate the prognostic role of mean corpuscular hemoglobin concentration 
      (MCHC) in hepatocellular carcinoma (HCC) after hepatectomy. Patients & methods: A 
      total of 289 HCC patients were classified into two groups based on the cut-off 
      value of MCHC. Significant prognostic factors were screened by univariate and 
      multivariate analysis. Results: Low MCHC value was significantly associated with 
      tumor diameter (p = 0.004) and vascular invasion (p = 0.038). Besides, Cox 
      regression analysis showed that low MCHC was significantly associated with poor 
      prognostic outcomes with HCC after hepatectomy (overall survival: hazard ratio: 
      0.372; 95% CI: 0.206-0.672; p = 0.001; recurrence-free survival: hazard ratio: 
      0.450; 95% confidence interval: 0.317-0.638; p < 0.001). Conclusion: Preoperative 
      MCHC can predict prognosis for patients with HCC, and the lower MCHC value was 
      associated with poor prognosis after hepatectomy.
FAU - Kong, Weihao
AU  - Kong W
AD  - Department of Emergency surgery, Department of Emergency Medicine, the First 
      Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
AD  - Department of Hepatic Surgery and Liver Transplantation Center of the Third 
      Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
AD  - Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver 
      Disease Biotherapy and Translational Medicine of Guangdong Higher Education 
      Institutes, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 
      510630, China.
FAU - Zheng, Jun
AU  - Zheng J
AD  - Department of Hepatic Surgery and Liver Transplantation Center of the Third 
      Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
AD  - Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver 
      Disease Biotherapy and Translational Medicine of Guangdong Higher Education 
      Institutes, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 
      510630, China.
FAU - Chen, Liang
AU  - Chen L
AD  - Department of Hepatic Surgery and Liver Transplantation Center of the Third 
      Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
AD  - Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver 
      Disease Biotherapy and Translational Medicine of Guangdong Higher Education 
      Institutes, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 
      510630, China.
FAU - Zuo, Xiaomin
AU  - Zuo X
AD  - Department of General Surgery, the First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, China.
FAU - Wang, Hengyi
AU  - Wang H
AD  - Department of Emergency surgery, Department of Emergency Medicine, the First 
      Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
FAU - Wang, Xingyu
AU  - Wang X
AD  - Department of Emergency surgery, Department of Emergency Medicine, the First 
      Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
FAU - Yao, Jia
AU  - Yao J
AD  - Department of Hepatic Surgery and Liver Transplantation Center of the Third 
      Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
AD  - Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver 
      Disease Biotherapy and Translational Medicine of Guangdong Higher Education 
      Institutes, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 
      510630, China.
FAU - Chen, Wei
AU  - Chen W
AD  - Department of General Surgery, the First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200305
PL  - England
TA  - Biomark Med
JT  - Biomarkers in medicine
JID - 101312535
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Carcinoma, Hepatocellular/*blood/*diagnosis/pathology/surgery
MH  - *Erythrocyte Indices
MH  - Female
MH  - Hepatectomy
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Liver Neoplasms/*blood/*diagnosis/pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - hepatectomy
OT  - hepatocellular carcinoma
OT  - mean corpuscular hemoglobin concentration
OT  - overall survival
OT  - recurrence-free survival
EDAT- 2020/03/07 06:00
MHDA- 2021/05/29 06:00
CRDT- 2020/03/06 06:00
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
PHST- 2020/03/06 06:00 [entrez]
AID - 10.2217/bmm-2019-0224 [doi]
PST - ppublish
SO  - Biomark Med. 2020 Mar;14(4):259-270. doi: 10.2217/bmm-2019-0224. Epub 2020 Mar 5.