PMID- 32134530
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 1521-4095 (Electronic)
IS  - 0935-9648 (Linking)
VI  - 32
IP  - 16
DP  - 2020 Apr
TI  - Nitric Oxide Release Device for Remote-Controlled Cancer Therapy by Wireless 
      Charging.
PG  - e2000376
LID - 10.1002/adma.202000376 [doi]
AB  - Traditional phototherapies face the issue that the insufficient penetration of 
      light means it is difficult to reach deep lesions, which greatly reduces the 
      feasibility of cancer therapy. Here, an implantable nitric oxide (NO)-release 
      device is developed to achieve long-term, long-distance, remote-controllable gas 
      therapy for cancer. The device consists of a wirelessly powered light-emitting 
      diode (wLED) and S-nitrosoglutathione encapsulated with poly(dimethylsiloxane) 
      (PDMS), obtaining the NO-release wLED (NO-wLED). It is found that NO release from 
      the NO-wLED can be triggered by wireless charging and the concentration of 
      produced NO reaches 0.43 x 10(-6) m min(-1) , which can achieve a killing effect 
      on cancer cells. In vivo anticancer experiments exhibit obvious inhibitory effect 
      on the growth of orthotopic cancer when the implanted NO-wLED is irradiated by 
      wireless charging. In addition, recurrence of cancer can be prevented by NO 
      produced from the NO-wLED after surgery. By illumination in the body, this 
      strategy overcomes the poor penetration and long-wavelength dependence of 
      traditional phototherapies, which also provides a promising approach for in vivo 
      gas therapy remote-controlled by wireless charging.
CI  - (c) 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Li, Bin
AU  - Li B
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education and Department of 
      Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
FAU - Ji, Ping
AU  - Ji P
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education and Department of 
      Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
FAU - Peng, Si-Yuan
AU  - Peng SY
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education and Department of 
      Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
FAU - Pan, Pei
AU  - Pan P
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education and Department of 
      Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
FAU - Zheng, Di-Wei
AU  - Zheng DW
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education and Department of 
      Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
FAU - Li, Chu-Xin
AU  - Li CX
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education and Department of 
      Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
FAU - Sun, Yun-Xia
AU  - Sun YX
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education and Department of 
      Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
FAU - Zhang, Xian-Zheng
AU  - Zhang XZ
AUID- ORCID: 0000-0001-6242-6005
AD  - Key Laboratory of Biomedical Polymers of Ministry of Education and Department of 
      Chemistry, Wuhan University, Wuhan, 430072, P. R. China.
LA  - eng
GR  - 51833007/National Natural Science Foundation of China/
GR  - 51690152/National Natural Science Foundation of China/
GR  - 51988102/National Natural Science Foundation of China/
GR  - 51873161/National Natural Science Foundation of China/
GR  - 21721005/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20200305
PL  - Germany
TA  - Adv Mater
JT  - Advanced materials (Deerfield Beach, Fla.)
JID - 9885358
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Colonic Neoplasms/metabolism/*therapy
MH  - Electric Power Supplies
MH  - Mice
MH  - Nitric Oxide/*metabolism
MH  - Phototherapy/*instrumentation
MH  - *Wireless Technology
OTO - NOTNLM
OT  - cancer therapy
OT  - nitric oxide
OT  - remote-control
OT  - wireless charging
EDAT- 2020/03/07 06:00
MHDA- 2021/01/12 06:00
CRDT- 2020/03/06 06:00
PHST- 2020/01/16 00:00 [received]
PHST- 2020/02/15 00:00 [revised]
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2020/03/06 06:00 [entrez]
AID - 10.1002/adma.202000376 [doi]
PST - ppublish
SO  - Adv Mater. 2020 Apr;32(16):e2000376. doi: 10.1002/adma.202000376. Epub 2020 Mar 
      5.