PMID- 32134592
OWN - NLM
STAT- MEDLINE
DCOM- 20200804
LR  - 20200804
IS  - 2791-6421 (Electronic)
IS  - 0041-4301 (Linking)
VI  - 61
IP  - 6
DP  - 2019
TI  - Rapid onset of altered mental status with progressive autonomic instability and 
      hypoventilation in a 2-year-old male.
PG  - 949-952
LID - 2086 [pii]
LID - 10.24953/turkjped.2019.06.019 [doi]
AB  - Nazari R, Carmona Jr CA. Rapid onset of altered mental status with progressive 
      autonomic instability and hypoventilation in a 2-year-old male. Turk J Pediatr 
      2019; 61: 949-952. Anti N-methyl-D-aspartate receptor (NMDAR) encephalitis should 
      be suspected in children who report with acute behavioral change, seizures, and 
      non-specific movement disorders. While historically associated with adolescent 
      females with ovarian teratoma, anti-NMDAR encephalitis has now been described in 
      the pediatric population of both sexes. These patients display the neurological 
      and psychiatric manifestations similar to females but lack a tumor. We report a 
      two-year-old previously healthy young male who presented with alteration in 
      speech, seizures, and extra pyramidal movement disorders. He was diagnosed with 
      anti-NMDAR encephalitis with positive cerebrospinal fluid (CSF) serology for 
      anti-NMDAR antibodies. In this case report, we describe the clinical 
      presentation, course of illness, investigation, and management of our patient. We 
      conclude by emphasizing three observations and insights from our case compared to 
      what is mentioned in the literature.
FAU - Nazari, Ramin
AU  - Nazari R
AD  - Department Pediatric Critical Care, Florida Hospital for Children, University of 
      Central Florida College of Medicine, Orlando, Florida-USA.
FAU - Carmona-Jr, Carlos A
AU  - Carmona-Jr CA
AD  - Department of Pediatrics, Florida Hospital for Children, University of Central 
      Florida College of Medicine, Orlando, Florida-USA.
LA  - eng
PT  - Case Reports
PL  - Turkey
TA  - Turk J Pediatr
JT  - The Turkish journal of pediatrics
JID - 0417505
RN  - 0 (Biomarkers)
RN  - 0 (GRIN1 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*complications/diagnosis
MH  - Biomarkers/cerebrospinal fluid
MH  - Cerebrospinal Fluid/metabolism
MH  - Child, Preschool
MH  - Humans
MH  - Hypoventilation/*etiology/physiopathology/surgery
MH  - Male
MH  - *Mental Health
MH  - Nerve Tissue Proteins/cerebrospinal fluid/immunology
MH  - Receptors, N-Methyl-D-Aspartate/immunology
MH  - Tracheostomy
OTO - NOTNLM
OT  - CSF serology
OT  - NMDA receptors
OT  - movement disorders
OT  - pediatric neurology
OT  - tumor
EDAT- 2019/01/01 00:00
MHDA- 2020/08/05 06:00
CRDT- 2020/03/06 06:00
PHST- 2020/03/06 06:00 [entrez]
PHST- 2019/01/01 00:00 [pubmed]
PHST- 2020/08/05 06:00 [medline]
AID - 2086 [pii]
AID - 10.24953/turkjped.2019.06.019 [doi]
PST - ppublish
SO  - Turk J Pediatr. 2019;61(6):949-952. doi: 10.24953/turkjped.2019.06.019.