PMID- 32134683
OWN - NLM
STAT- MEDLINE
DCOM- 20210604
LR  - 20210604
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 45
IP  - 8
DP  - 2020 Aug
TI  - Effects of exercise training and sex on dynamic responses of O(2) uptake in type 
      2 diabetes.
PG  - 865-874
LID - 10.1139/apnm-2019-0636 [doi]
AB  - Effects of training and sex on oxygen uptake dynamics during exercise in type 2 
      diabetes mellitus (T2DM) are not well established. We tested the hypotheses that 
      exercise training improves the time constant of the primary phase of oxygen 
      uptake (tau(p) oxygen uptake) and with greater effect in males than females. 
      Forty-one subjects with T2DM were assigned to 2 training groups (T(male), 
      T(female)) and 2 control groups (C(male), C(female)), and were assessed before 
      and after a 12-week intervention period. Twelve weeks of aerobic/resistance 
      training was performed 3 times per week, 60-90 min per session. Assessments 
      included ventilatory threshold (VT), peak oxygen uptake, tau(p) oxygen uptake 
      (80%VT), and dynamic responses of cardiac output, mean arterial pressure and 
      systemic vascular conductance (80%VT). Training significantly decreased tau(p) 
      oxygen uptake in males by a mean of 20% (T(male) = 42.7 +/- 6.2 to 34.3 +/- 7.2 s) 
      and females by a mean of 16% (T(female) = 42.2 +/- 9.3 to 35.4 +/- 8.6 s); whereas 
      tau(p) oxygen uptake was not affected in controls (C(male) = 41.6 +/- 9.8 to 42.9 +/- 
      7.6 s; C(female) = 40.4 +/- 12.2 to 40.6 +/- 13.4 s). Training increased peak oxygen 
      uptake in both sexes (12%-13%) but did not alter systemic cardiovascular dynamics 
      in either sex. Training improved oxygen uptake dynamics to a similar extent in 
      males and females in the absence of changes in systemic cardiovascular dynamics. 
      Novelty Similar training improvements in oxygen uptake dynamics were observed in 
      males and females with T2DM. In both sexes these improvements occurred without 
      changes in systemic cardiovascular dynamics.
FAU - Green, Simon
AU  - Green S
AD  - School of Science and Health, Western Sydney University, Sydney 2567, Australia.
AD  - School of Medicine, Western Sydney University, Sydney 2567, Australia.
FAU - Kiely, Catherine
AU  - Kiely C
AD  - Department of Physiology, School of Medicine, Trinity College Dublin, Dublin 2, 
      Ireland.
FAU - O'Connor, Eamonn
AU  - O'Connor E
AD  - Department of Physiology, School of Medicine, Trinity College Dublin, Dublin 2, 
      Ireland.
FAU - Gildea, Norita
AU  - Gildea N
AD  - Department of Physiology, School of Medicine, Trinity College Dublin, Dublin 2, 
      Ireland.
FAU - O'Shea, Donal
AU  - O'Shea D
AD  - Endocrinology, St Columcille's and St Vincent's Hospitals, Dublin, Dublin 18, 
      Ireland.
FAU - Egana, Mikel
AU  - Egana M
AD  - Department of Physiology, School of Medicine, Trinity College Dublin, Dublin 2, 
      Ireland.
LA  - eng
PT  - Journal Article
DEP - 20200305
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
SB  - IM
MH  - Aged
MH  - Blood Pressure
MH  - Cardiac Output
MH  - Cardiovascular System
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - *Exercise
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxygen Consumption
MH  - *Resistance Training
OTO - NOTNLM
OT  - aptitude cardiorespiratoire
OT  - cardiorespiratory fitness
OT  - cardiovasculaire
OT  - cardiovascular
OT  - diabetes
OT  - diabete
OT  - maximal
OT  - patients
OT  - sous-maximal
OT  - submaximal
EDAT- 2020/03/07 06:00
MHDA- 2021/06/05 06:00
CRDT- 2020/03/06 06:00
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2021/06/05 06:00 [medline]
PHST- 2020/03/06 06:00 [entrez]
AID - 10.1139/apnm-2019-0636 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2020 Aug;45(8):865-874. doi: 10.1139/apnm-2019-0636. 
      Epub 2020 Mar 5.