PMID- 32135591
OWN - NLM
STAT- MEDLINE
DCOM- 20200316
LR  - 20211204
IS  - 0578-1310 (Print)
IS  - 0578-1310 (Linking)
VI  - 58
IP  - 3
DP  - 2020 Mar 2
TI  - [Predictive values of routine blood test results for iron deficiency in 
      children].
PG  - 201-205
LID - 10.3760/cma.j.issn.0578-1310.2020.03.008 [doi]
AB  - Objective: To explore the predictive values of routine blood test results for 
      iron deficiency (ID) screening in children. Methods: Routine blood test results 
      and serum ferritin (SF) levels from 1 443 healthy children (862 boys, 581 girls) 
      aged 6 months to 18 years, who were seen for well-child visits between June 2017 
      and May 2019 in Children's Hospital, Zhejiang University School of Medicine, were 
      retrospectively analyzed. ID was defined as SF<20 mug/L, iron deficiency anemia 
      (IDA) as ID with anemia (hemoglobin(Hb)<110 g/L at 6 months-5 years of age, 
      Hb<120 g/L at 6-18 years of age), non-anemia ID as ID without anemia, non-ID 
      anemia as SF>/=20 mug/L with anemia, and healthy control subjects as those with 
      SF>/=20 mug/L but without anemia. The blood test results including Hb, mean 
      corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), red 
      blood cell distribution width (RDW), and the percentage of low hemoglobin density 
      (LHD) of healthy control, non-anemia ID, non-ID anemia, and IDA groups were 
      compared by analysis of variance (ANOVA) or non-parametric test, quantitative 
      data were described as x+/-s or M(interquartile range), and receiver operating 
      characteristic curve (ROC) analysis was applied to assess predictive values of 
      routine blood test results and LHD for detecting IDA and ID. Results: Among 1 443 
      children with median age of 2.1(3.3) years, 1 061 children were in healthy 
      control group, 292 in non-anemia ID group, 43 in non-ID anemia group and 47 in 
      IDA group. The prevalence of ID was much higher than that of anemia (23.5% (339/1 
      443) vs. 6.2% (90/1 443) , chi(2)=169.76, P<0.01). Compared with control group, 
      non-anemia ID group showed higher LHD (0.088 (0.093) vs.0.073 (0.068), P<0.01) 
      and RDW (0.131+/-0.013 vs. 0.126+/-0.008, P<0.01), lower MCV ((80+/-4) vs. (83+/-4) fl, 
      P<0.01) and MCHC values ((326+/-9) vs. (329+/-8) g/L, P<0.01). IDA group showed 
      higher LHD (0.322(0.544)) and RDW (0.151+/-0.018), lower MCV ((73+/-6) fl) and MCHC 
      values((309+/-14) g/L) than non-anemia ID group (all P<0.01). The area under curve 
      (AUC) values of MCHC, LHD, RDW and MCV for detecting ID were 0.63 (95%CI: 
      0.60-0.67), 0.63 (95%CI:0.60-0.67), 0.67 (95%CI: 0.63-0.70) and 0.73 (95%CI: 
      0.69-0.76) respectively. With cutoff limits (MCV<80.2 fl, RDW>0.131 or MCHC<322 
      g/L), MCV, RDW and MCHC showed higher sensitivity for screening ID than 
      hemoglobin (0.540, 0.469 and 0.336 vs. 0.139, chi(2)=121.70, 87.47, 35.56, all 
      P<0.01). Conclusion: MCV, RDW and MCHC can be used to screen ID in primary health 
      care settings.
FAU - Zhan, J Y
AU  - Zhan JY
AD  - Department of Pediatric Health Care, Children's Hospital, Zhejiang University 
      School of Medicine, National Clinical Research Center for Child Health, Hangzhou 
      310003, China.
FAU - Zheng, S S
AU  - Zheng SS
AD  - Department of Pediatric Health Care, Children's Hospital, Zhejiang University 
      School of Medicine, National Clinical Research Center for Child Health, Hangzhou 
      310003, China.
FAU - Dong, W W
AU  - Dong WW
AD  - Department of Pediatric Health Care, Children's Hospital, Zhejiang University 
      School of Medicine, National Clinical Research Center for Child Health, Hangzhou 
      310003, China.
FAU - Shao, J
AU  - Shao J
AD  - Department of Pediatric Health Care, Children's Hospital, Zhejiang University 
      School of Medicine, National Clinical Research Center for Child Health, Hangzhou 
      310003, China.
LA  - chi
GR  - 81773440/National Natural Sciences Foundation of China General Program/
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Ke Za Zhi
JT  - Zhonghua er ke za zhi = Chinese journal of pediatrics
JID - 0417427
RN  - 0 (Hemoglobins)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adolescent
MH  - Anemia/*diagnosis/epidemiology
MH  - Anemia, Iron-Deficiency/blood/*diagnosis/epidemiology
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Erythrocyte Indices
MH  - Erythrocytes/chemistry
MH  - Female
MH  - Hemoglobins/chemistry
MH  - Humans
MH  - Infant
MH  - Iron/blood
MH  - Iron Deficiencies
MH  - Male
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Anemia, iron deficiency
OT  - Child
OT  - Percentage of low hemoglobin density
OT  - Red cell distribution width
EDAT- 2020/03/07 06:00
MHDA- 2020/03/17 06:00
CRDT- 2020/03/06 06:00
PHST- 2020/03/06 06:00 [entrez]
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2020/03/17 06:00 [medline]
AID - 10.3760/cma.j.issn.0578-1310.2020.03.008 [doi]
PST - ppublish
SO  - Zhonghua Er Ke Za Zhi. 2020 Mar 2;58(3):201-205. doi: 
      10.3760/cma.j.issn.0578-1310.2020.03.008.