PMID- 3213641
OWN - NLM
STAT- MEDLINE
DCOM- 19890222
LR  - 20191022
VI  - 43
DP  - 1988
TI  - The investigation of experimental brain tumours using 31P-MRS and 1H-MRI.
PG  - 140-4
AB  - In vivo 31P-magnetic resonance spectra (MRS) were obtained by the surface coil 
      method from rat glioma, human glioblastoma, and human neuroblastoma inoculated 
      subcutaneously in CD Fisher rats and hamsters, and the effects of chemotherapy, 
      photoradiation therapy, and radiofrequency hyperthermia as well as 
      60Co-irradiation were evaluated by sequentially observing spectral changes. In 
      the 31P-spectra of tumour tissue, the nucleoside triphosphate (NTP), 
      phosphomonoesters (PME) peaks were high and the phosphocreatine peak was low 
      compared to those of normal brain. When the antitumour agents were given and were 
      effective, NTP peaks decreased, and inorganic phosphate increased remarkably 
      within several hours after the treatment. 1H-magnetic resonance imaging (MRI) 
      were also obtained in some cases. Necrotic regions was detected by the 1H-MRI as 
      image changes which appeared later than those detected by MRS. It proved 
      practical to monitor the effect of therapy by employing either 31P-MRS or 1H-MRI. 
      However, the image changes which demonstrated the effect of the therapy used 
      closely resembled those changes which occurred with the onset of necrosis in 
      tumour tissue during tumour growth. Several problems for future application of 
      these techniques to human brain tumours are also mentioned.
FAU - Hirakawa, K
AU  - Hirakawa K
AD  - Department of Neurosurgery, Kyoto Prefectural University of Medicine, Japan.
FAU - Naruse, S
AU  - Naruse S
FAU - Higuchi, T
AU  - Higuchi T
FAU - Horikawa, Y
AU  - Horikawa Y
FAU - Tanaka, C
AU  - Tanaka C
FAU - Ebisu, T
AU  - Ebisu T
LA  - eng
PT  - Journal Article
PL  - Austria
TA  - Acta Neurochir Suppl (Wien)
JT  - Acta neurochirurgica. Supplementum
JID - 0140560
RN  - 0 (Antineoplastic Agents)
RN  - 27YLU75U4W (Phosphorus)
RN  - 7YNJ3PO35Z (Hydrogen)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - Brain Neoplasms/*diagnosis/pathology
MH  - Cricetinae
MH  - Hydrogen
MH  - *Magnetic Resonance Imaging
MH  - *Magnetic Resonance Spectroscopy
MH  - Phosphorus
MH  - Rats
MH  - Tumor Cells, Cultured
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1007/978-3-7091-8978-8_30 [doi]
PST - ppublish
SO  - Acta Neurochir Suppl (Wien). 1988;43:140-4. doi: 10.1007/978-3-7091-8978-8_30.