PMID- 32138454
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210110
IS  - 1559-0097 (Electronic)
IS  - 1046-3976 (Linking)
VI  - 5
IP  - 4
DP  - 1994 Dec
TI  - Ki-67 is an indicator of progression of neuroendocrine tumors.
PG  - 223-228
LID - 10.1007/BF02921490 [doi]
AB  - No current histological or cytological indices can distinguish reliably malignant 
      from benign tumors in neuroendocrine tumors, including pheochromocytomas, 
      pancreatic endocrine tumors, and carcinoid tumors. We investigated 
      immunohistochemically the expression of Ki-67 in 52 neuroendocrine tumors, 
      including 17 pheochromocytomas, 9 pancreatic endocrine tumors, 23 carcinoid 
      tumors, 2 neuroendocrine carcinomas (NEC), and 1 neuroblastoma with liver 
      metastasis. Of the 52 tumors, distant metastasis was observed in 4 
      pheochromocytomas, 2 pancreatic endocrine tumors, 4 carcinoids, 2 NEC, and 1 
      neuroblastoma. We classified these tumors into 3 groups; Groups A, B, and C, 
      depending on the number of Ki-67-positive cells counted under a 200 x magnified 
      field. Expression of Ki-67 was extremely high in group A (> 50 labeled 
      nuclei/field), moderately high in group B (20-50 labeled nuclei), and very low in 
      group C (< 10 labeled nuclei). There was a significant correlation between 
      expression of Ki-67 and tumor progression. The tumors in group A progressed 
      rapidly with the worst outcome; the tumors in group B progressed slowly but with 
      a bad outcome; and the tumors in group C had no metastasis and a good prognosis. 
      Ki-67 is an excellent indicator to assess progression of neuroendocrine tumors.
FAU - Kimura, Noriko
AU  - Kimura N
AD  - Department of Pathology, Tohoku University School of Medicine, 1-2 Sciryomachi 
      Aoba-ku, 980, Sendai, Japan.
FAU - Miura, Wakako
AU  - Miura W
AD  - Department of Second Internal Medicine, Tohoku University School of Medicine, 
      Japan.
FAU - Noshiro, Takao
AU  - Noshiro T
AD  - Department of Second Internal Medicine, Tohoku University School of Medicine, 
      Japan.
FAU - Miura, Yukio
AU  - Miura Y
AD  - Department of Second Internal Medicine, Tohoku University School of Medicine, 
      Japan.
FAU - Ookuma, Tsuneo
AU  - Ookuma T
AD  - Department of Second Surgery, Tohoku University School of Medicine, Japan.
FAU - Nagura, Hiroshi
AU  - Nagura H
AD  - Department of Pathology, Tohoku University School of Medicine, 1-2 Sciryomachi 
      Aoba-ku, 980, Sendai, Japan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Endocr Pathol
JT  - Endocrine pathology
JID - 9009288
SB  - IM
OTO - NOTNLM
OT  - Carcinoid Tumor
OT  - Endocrine Pathology Volume
OT  - Neuroblastoma
OT  - Neuroendocrine Carcinoma
OT  - Neuroendocrine Tumor
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 2020/03/07 06:00
PHST- 2020/03/07 06:00 [entrez]
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
AID - 10.1007/BF02921490 [pii]
AID - 10.1007/BF02921490 [doi]
PST - ppublish
SO  - Endocr Pathol. 1994 Dec;5(4):223-228. doi: 10.1007/BF02921490.