PMID- 32140278
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2151-321X (Print)
IS  - 2151-3228 (Electronic)
IS  - 2151-321X (Linking)
VI  - 32
IP  - 3
DP  - 2019 Sep 1
TI  - Factors Associated with Positive Adenosine Challenge Test in Young Children with 
      Suspected Asthma.
PG  - 103-108
LID - 10.1089/ped.2019.1028 [doi]
AB  - Background: To investigate the predictive factors associated with positive 
      adenosine monophosphate challenge using the auscultation method (AMP-PCW) test 
      results. Methods: This is a prospective study of young children with suspected 
      asthma who underwent AMP-PCW test. Patients with a positive AMP-PCW test were 
      compared with those with a negative AMP-PCW. A multivariate logistic regression 
      model was performed to identify the independent determinants of positive AMP-PCW. 
      Results: A total of 159 patients completed the AMP-PCW test. The median age was 
      53 months. In total, 54.0% of patients had a positive AMP-PCW. The prevalence of 
      atopic dermatitis and family history of asthma and allergy were significantly 
      higher among the positive AMP-PCW group (P = 0.04, P = 0.02, and P = 0.007, 
      respectively), as were the prevalences of elevated immunoglobulin E (IgE), 
      peripheral blood eosinophils percentage (P = 0.003, P < 0.001, respectively), and 
      number of emergency department (ED) visits/hospitalizations before AMP-PCW test 
      (P = 0.006). A significant inverse correlation exists between peripheral blood 
      eosinophils percentage and serum IgE levels with the AMP end-point concentrations 
      (r = -0.302, P = 0.001, and r = -0.312, P = 0.001, respectively). In multivariate 
      logistic regression model, peripheral blood eosinophils percentage, IgE levels, 
      and the number of ED visits/hospitalizations before the AMP-PCW test were found 
      as independent predictors for positive AMP-PCW test result. Conclusions: Our 
      results suggest that bronchial responsiveness to AMP-PCW is related to proxy 
      markers of airway inflammation (elevated eosinophils and IgE levels) and clinical 
      exacerbation of asthma before the test. This may support the role of AMP-PCW in 
      detecting inflammatory changes and monitoring their trend among young children 
      with suspected asthma.
CI  - Copyright 2019, Mary Ann Liebert, Inc., publishers.
FAU - Levin, Gabriel
AU  - Levin G
AD  - Department of Obstetrics and Gynecology, Hadassah University Medical Center, 
      Jerusalem, Israel.
FAU - Cohen, Shlomo
AU  - Cohen S
AD  - Institute of Pulmonology, Shaare Zedek Medical Center, Jerusalem, Israel.
FAU - Springer, Chaim
AU  - Springer C
AD  - Institute of Pulmonology, Hadassah University Medical Center, Jerusalem, Israel.
FAU - Avital, Avraham
AU  - Avital A
AD  - Institute of Pulmonology, Hadassah University Medical Center, Jerusalem, Israel.
FAU - Picard, Elie
AU  - Picard E
AD  - Institute of Pulmonology, Shaare Zedek Medical Center, Jerusalem, Israel.
FAU - Rottensctreich, Amihai
AU  - Rottensctreich A
AD  - Department of Obstetrics and Gynecology, Hadassah University Medical Center, 
      Jerusalem, Israel.
LA  - eng
PT  - Journal Article
DEP - 20190917
PL  - United States
TA  - Pediatr Allergy Immunol Pulmonol
JT  - Pediatric allergy, immunology, and pulmonology
JID - 101549629
PMC - PMC7057053
OTO - NOTNLM
OT  - adenosine
OT  - asthma
OT  - challenge test
OT  - hyper-responsiveness
OT  - wheezing
COIS- The authors report no conflicts of interest. The authors alone are responsible 
      for the content and writing of the article.
EDAT- 2020/03/07 06:00
MHDA- 2020/03/07 06:01
PMCR- 2020/03/01
CRDT- 2020/03/07 06:00
PHST- 2019/04/08 00:00 [received]
PHST- 2019/06/29 00:00 [accepted]
PHST- 2020/03/07 06:00 [entrez]
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2020/03/07 06:01 [medline]
PHST- 2020/03/01 00:00 [pmc-release]
AID - 10.1089/ped.2019.1028 [pii]
AID - 10.1089/ped.2019.1028 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol Pulmonol. 2019 Sep 1;32(3):103-108. doi: 
      10.1089/ped.2019.1028. Epub 2019 Sep 17.