PMID- 32140284
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2151-321X (Print)
IS  - 2151-3228 (Electronic)
IS  - 2151-321X (Linking)
VI  - 32
IP  - 3
DP  - 2019 Sep 1
TI  - A Case of Anaphylaxis to Measles Vaccination in an Infant with Cow's Milk 
      Allergy.
PG  - 135-138
LID - 10.1089/ped.2019.0993 [doi]
AB  - Background: Cow's milk is one of the most common of the foods that cause food 
      allergies in children. Here, we present a 10-month-old male who was diagnosed 
      with having an allergy to cow's milk and who developed an anaphylactic reaction 
      after being recently vaccinated with a measles vaccine. Case: The patient had 
      been diagnosed with atopic dermatitis and cow's milk allergy at 40 days old after 
      a rash appeared on his face and arms while exclusively breastfeeding. At 9 
      months, on his routine welfare outpatient appointment, he developed a facial rash 
      and swelling, wheezing, difficulty breathing, and cyanosis within 10 min of 
      having his first measles vaccination (M-VAC((R)); Serum Institute of India, 
      Hadapsar, Pune, India). After an allergy evaluation and a physical examination 
      that showed that he was otherwise healthy, he was diagnosed with an allergy to 
      cow's milk, which was then eliminated from his diet. Laboratory evaluations were 
      as follows: serum immunoglobulin E (IgE) to cow's milk: 36.2 kU/L, alpha-lactalbumin: 
      9.39 kU/L, beta-lactoglobulin: 8.74 kU/L, casein: 34.2 kU/L, latex-specific (sp)IgE: 
      0.10 kU/L, gelatin spIgE: <0.35 kU/L (normal levels <0.35 kU/L; Pharmacia, 
      Uppsala, Sweden). Results revealed lactalbumin hydrolysate as one of the M-VAC 
      ingredients according to the manufacturer's package insert. Conclusion: In most 
      cases with a cow's milk allergy, vaccines are administered without any problems 
      because the amount of milk proteins contained in the vaccines is not sufficient 
      to represent a risk factor for anaphylaxis; however, the vaccine content should 
      be examined for possible allergens, particularly for children with food 
      allergies, before vaccinating. We should keep in mind when determining the agent 
      responsible for an allergic reaction that the risk from a residual component of 
      milk protein in vaccines can differ according to the nutritional habits of the 
      population.
CI  - Copyright 2019, Mary Ann Liebert, Inc., publishers.
FAU - Sipahi, Sevgi
AU  - Sipahi S
AD  - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Istanbul 
      Faculty of Medicine, Istanbul University, Istanbul, Turkey.
FAU - Ozceker, Deniz
AU  - Ozceker D
AD  - Department of Pediatric Allergy and Clinic Immunology, Okmeydani Training and 
      Research Hospital, Istanbul, Turkey.
FAU - Gokcay, Gulbin
AU  - Gokcay G
AD  - Well Child Unit, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul 
      University, Istanbul, Turkey.
FAU - Guler, Nermin
AU  - Guler N
AD  - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Istanbul 
      Faculty of Medicine, Istanbul University, Istanbul, Turkey.
FAU - Tamay, Zeynep
AU  - Tamay Z
AD  - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Istanbul 
      Faculty of Medicine, Istanbul University, Istanbul, Turkey.
LA  - eng
PT  - Case Reports
DEP - 20190917
PL  - United States
TA  - Pediatr Allergy Immunol Pulmonol
JT  - Pediatric allergy, immunology, and pulmonology
JID - 101549629
PMC - PMC7057048
OTO - NOTNLM
OT  - allergy
OT  - anaphylaxis
OT  - cow's milk
OT  - measles
OT  - vaccination
COIS- No competing financial interests exist.
EDAT- 2020/03/07 06:00
MHDA- 2020/03/07 06:01
PMCR- 2020/03/01
CRDT- 2020/03/07 06:00
PHST- 2019/01/14 00:00 [received]
PHST- 2019/06/08 00:00 [accepted]
PHST- 2020/03/07 06:00 [entrez]
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2020/03/07 06:01 [medline]
PHST- 2020/03/01 00:00 [pmc-release]
AID - 10.1089/ped.2019.0993 [pii]
AID - 10.1089/ped.2019.0993 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol Pulmonol. 2019 Sep 1;32(3):135-138. doi: 
      10.1089/ped.2019.0993. Epub 2019 Sep 17.