PMID- 32140726
OWN - NLM
STAT- MEDLINE
DCOM- 20201229
LR  - 20230503
IS  - 1460-2377 (Electronic)
IS  - 0953-8178 (Linking)
VI  - 32
IP  - 7
DP  - 2020 Jun 26
TI  - Metabolic and immunologic control of intestinal cell function by mTOR.
PG  - 455-465
LID - 10.1093/intimm/dxaa015 [doi]
AB  - The intestinal epithelium is one of the most quickly dividing tissues in our 
      body, combining the absorptive advantages of a single layer with the protection 
      of a constantly renewing barrier. It is continuously exposed to nutrients and 
      commensal bacteria as well as microbial and host-derived metabolites, but also to 
      hazards such as pathogenic bacteria and toxins. These environmental cues are 
      sensed by the mucosa and a vast repertory of immune cells, especially 
      macrophages. A disruption of intestinal homeostasis in terms of barrier 
      interruption can lead to inflammatory bowel diseases and colorectal cancer, and 
      macrophages have an important role in restoring epithelial function following 
      injury. The mammalian/mechanistic target of rapamycin (mTOR) signalling pathway 
      senses environmental cues and integrates metabolic responses. It has emerged as 
      an important regulator of intestinal functions in homeostasis and disease. In 
      this review, we are going to discuss intestinal mTOR signalling and metabolic 
      regulation in different intestinal cell populations with a special focus on 
      immune cells and their actions on intestinal function.
CI  - (c) The Japanese Society for Immunology. 2020. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Fritsch, Stephanie D
AU  - Fritsch SD
AD  - Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical 
      University of Vienna, Wahringer Strasse, Vienna, Austria.
FAU - Weichhart, Thomas
AU  - Weichhart T
AD  - Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical 
      University of Vienna, Wahringer Strasse, Vienna, Austria.
LA  - eng
GR  - P 27701/FWF_/Austrian Science Fund FWF/Austria
GR  - P 30857/FWF_/Austrian Science Fund FWF/Austria
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Intestines/cytology/*immunology
MH  - Signal Transduction/immunology
MH  - TOR Serine-Threonine Kinases/*immunology/*metabolism
OTO - NOTNLM
OT  - colon cancer
OT  - epithelial regeneration
OT  - immunometabolism
OT  - inflammatory bowel disease
OT  - macrophages
EDAT- 2020/03/07 06:00
MHDA- 2020/12/30 06:00
CRDT- 2020/03/07 06:00
PHST- 2020/02/19 00:00 [received]
PHST- 2020/02/28 00:00 [accepted]
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2020/12/30 06:00 [medline]
PHST- 2020/03/07 06:00 [entrez]
AID - 5788241 [pii]
AID - 10.1093/intimm/dxaa015 [doi]
PST - ppublish
SO  - Int Immunol. 2020 Jun 26;32(7):455-465. doi: 10.1093/intimm/dxaa015.