PMID- 32141346
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 45
IP  - 10
DP  - 2020 Oct
TI  - Analysis of Choroidal Thickness in Children with Congenital Aniridia.
PG  - 1292-1297
LID - 10.1080/02713683.2020.1736309 [doi]
AB  - Purpose: To evaluate the choroidal thickness (CT) in children with congenital 
      aniridia in comparison with age-matched controls. Methods: This was a 
      cross-sectional, observational study that included 64 eyes of 32 children with 
      congenital aniridia (aged 5-12 years) and 80 eyes of 40 healthy subjects who were 
      age-matched. In all subjects, subfoveal choroidal thickness (SFCT) was assessed 
      at 750-mum intervals from the fovea to 1.5 mm in the temporal and nasal directions 
      with spectral-domain optical coherence tomography (SD-OCT). Results: The mean 
      SFCT was 207.67 +/- 30.99 microm in the aniridic eyes. This SFCT was significantly 
      thinner than that in control eyes (288.55 +/- 30.06 microm) (P < .001). The SFCTs at 
      1.5 mm and 0.75 mm intervals in the temporal and nasal directions from the fovea 
      were also significantly thinner in eyes with aniridia than control eyes (P 
      < .001).There was a significant negative correlation between the SFCT and axial 
      length in eyes with aniridia (B = -10.60, 95%CI = -19.31~-1.89, P = .017). 
      Conclusions: The subfoveal and parafoveal CTs were significantly thinner in eyes 
      with congenital aniridia than in control eyes. These choroidal changes could open 
      up a new way for the research related to the pathophysiology of congenital 
      aniridia.
FAU - Chen, Hui
AU  - Chen H
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University , Guangzhou, China.
FAU - Wu, Xiaohang
AU  - Wu X
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University , Guangzhou, China.
FAU - Li, Xiaoyan
AU  - Li X
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University , Guangzhou, China.
FAU - Chen, Jingjing
AU  - Chen J
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University , Guangzhou, China.
FAU - Lin, Zhuoling
AU  - Lin Z
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University , Guangzhou, China.
FAU - Chen, Weirong
AU  - Chen W
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University , Guangzhou, China.
FAU - Lin, Haotian
AU  - Lin H
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University , Guangzhou, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200306
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
SB  - IM
MH  - Adolescent
MH  - Aniridia/diagnostic imaging/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Choroid/diagnostic imaging/*pathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Organ Size
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - Congenital aniridia
OT  - choroidal thickness
OT  - optical coherence tomography (OCT)
EDAT- 2020/03/07 06:00
MHDA- 2021/10/16 06:00
CRDT- 2020/03/07 06:00
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2020/03/07 06:00 [entrez]
AID - 10.1080/02713683.2020.1736309 [doi]
PST - ppublish
SO  - Curr Eye Res. 2020 Oct;45(10):1292-1297. doi: 10.1080/02713683.2020.1736309. Epub 
      2020 Mar 6.