PMID- 32142998
OWN - NLM
STAT- MEDLINE
DCOM- 20210226
LR  - 20210226
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 14
IP  - 3
DP  - 2020 May-Jun
TI  - rs7903146 (C/T) polymorphism of Transcription factor 7 like 2 (TCF7L-2) gene is 
      independently associated with non-alcoholic fatty liver disease in Asian Indians.
PG  - 175-180
LID - S1871-4021(20)30032-1 [pii]
LID - 10.1016/j.dsx.2020.02.011 [doi]
AB  - BACKGROUND AND AIMS: Transcription factor 7 like 2 (TCF7L-2) polymorphism has 
      been associated with adipocyte metabolism and insulin resistance. Genetic 
      investigations of non-alcoholic fatty liver disease (NAFLD) with obesity, type 2 
      diabetes mellitus (T2DM) and atherosclerosis are unknown. This study was designed 
      to investigate the association of rs7903146 (C/T) polymorphism of TCF7L-2 gene 
      with non-alcoholic fatty liver disease (NAFLD) in Asian Indians. METHODS: In this 
      case-control study 162 non-diabetic subjects with NAFLD and 173 body mass index 
      (BMI)-matched controls without NAFLD were recruited. Abdominal ultrasound, 
      clinical and biochemical investigations, fasting insulin levels and value of 
      homeostasis model assessment of insulin resistance (HOMA-IR) was measured. Single 
      nucleotide polymorphism rs7903146 (C/T) was genotyped by polymerase chain 
      reaction-restriction fragment length polymorphisms. RESULTS: The distribution of 
      rs7903146 (C/T) alleles, the dominant model (CT + TT) and higher frequency (31%) 
      of C/T genotype were significantly associated with NAFLD. C/T genotype of TCF7L2 
      gene was associated with significantly higher levels of BMI (p = 0.02), abdominal 
      obesity (p < 0.05), fasting blood glucose (p = 0.05), hepatic transaminases 
      (p < 0.05) and markers of insulin resistance (p < 0.05) in subjects with NAFLD. 
      Using a multivariate analysis after adjusting for age and sex, TCF7L2 
      polymorphism was independently associated with presence of NAFLD [(OR: 3.234 (95% 
      CI: 1.219-4.160, p = 0.002)]. CONCLUSION: TCF7L2 (C/T) gene was Independently 
      associated with NAFLD in Asian Indians.
CI  - Copyright (c) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Bhatt, Surya Prakash
AU  - Bhatt SP
AD  - Diabetes Foundation (India), Safdarjung Development Area, New Delhi, 110016, 
      India; National Diabetes Obesity and Cholesterol Foundation (N-DOC), Safdarjung 
      Development Area, New Delhi, 110016, India; Department of Pulmonary, Critical 
      Care and Sleep Medicine, All India Institute of Medical Sciences, Ansari Nagar, 
      New Delhi, 110029, India; Fortis C-DOC Center of Excellence for Diabetes, 
      Metabolic Diseases, and Endocrinology, B-16, Chirag Enclave, New Delhi, India.
FAU - Misra, Anoop
AU  - Misra A
AD  - Diabetes Foundation (India), Safdarjung Development Area, New Delhi, 110016, 
      India; National Diabetes Obesity and Cholesterol Foundation (N-DOC), Safdarjung 
      Development Area, New Delhi, 110016, India; Fortis C-DOC Center of Excellence for 
      Diabetes, Metabolic Diseases, and Endocrinology, B-16, Chirag Enclave, New Delhi, 
      India. Electronic address: anoopmisra@gmail.com.
FAU - Pandey, Ravindra Mohan
AU  - Pandey RM
AD  - Biostatics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 
      110029, India.
LA  - eng
PT  - Journal Article
DEP - 20200221
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - India/epidemiology
MH  - Insulin/blood
MH  - Insulin Resistance/genetics
MH  - Liver Function Tests
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/*epidemiology/*genetics
MH  - Obesity, Abdominal/epidemiology/genetics
MH  - Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Transcription Factor 7-Like 2 Protein/*genetics
OTO - NOTNLM
OT  - Asian Indians
OT  - Non-alcoholic fatty liver disease
OT  - Transcription factor 7 like 2
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest The authors declare that they have no competing 
      interests.
EDAT- 2020/03/07 06:00
MHDA- 2021/02/27 06:00
CRDT- 2020/03/07 06:00
PHST- 2020/02/18 00:00 [received]
PHST- 2020/02/18 00:00 [revised]
PHST- 2020/02/18 00:00 [accepted]
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2021/02/27 06:00 [medline]
PHST- 2020/03/07 06:00 [entrez]
AID - S1871-4021(20)30032-1 [pii]
AID - 10.1016/j.dsx.2020.02.011 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2020 May-Jun;14(3):175-180. doi: 10.1016/j.dsx.2020.02.011. 
      Epub 2020 Feb 21.