PMID- 32143077
OWN - NLM
STAT- MEDLINE
DCOM- 20200603
LR  - 20200603
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 251
DP  - 2020 Jul
TI  - A sensitive method for simultaneous determination of 12 classes of per- and 
      polyfluoroalkyl substances (PFASs) in groundwater by ultrahigh performance liquid 
      chromatography coupled with quadrupole orbitrap high resolution mass 
      spectrometry.
PG  - 126327
LID - S0045-6535(20)30520-8 [pii]
LID - 10.1016/j.chemosphere.2020.126327 [doi]
AB  - Per- and polyfluoroalkyl substances (PFASs) comprise a large group of chemicals 
      with diverse physicochemical properties, which make their simultaneous 
      determination a challenging task. A trace analytical method based on ultrahigh 
      performance liquid chromatography-quadrupole Orbitrap high resolution mass 
      spectrometry (UHPLC-Q-Orbitrap HRMS) was developed for simultaneous determination 
      of 54 PFASs belonging to 12 classes in groundwater, including 24 perfluorocarbons 
      and 30 precursors. This method provided good linearity of calibration standards 
      (R(2) > 0.99), excellent method limits of quantification (MLOQs) (0.5-250 pg/L), 
      satisfactory matrix spiking recoveries (63%-148%), high precision (intra-day 
      relative standard deviations (RSDs) 1.4-11.4%, inter-day RSDs 1.6-12.9%, and 
      inter-week RSDs 2.1-12.7%), and short runtime (13 min), suitable for high 
      throughput studies. The newly established method was successfully applied to 
      detect PFASs in the groundwater samples collected from Hebei Province, China. 
      Twenty PFASs were detected with the total concentration of 0.3-32.9 ng/L, 
      indicating the contamination level similar to that in drinking water. The 
      dominant PFASs were perfluorobutanesulfonate (PFBS), perfluorobutanoic acid 
      (PFBA), perfluoropentanoic acid (PFPeA) and perfluorooctanoic acid (PFOA). In 
      addition, 6:2 fluorotelomer phosphate diester (6:2 diPAP) and 6:2 fluorotelomer 
      sulfonate (6:2 FTS) were found as the major precursors. The total PFAS 
      concentrations were lower than the cumulative permissible limit of 70 ng/L for 
      PFOS and PFOA recommended by the United States Environmental Protection Agency 
      (USEPA) for drinking water in 2016. In a nutshell, this study provided a fast and 
      sensitive method based on HRMS for the simultaneous analysis of a wide range of 
      PFASs, present at trace levels in groundwater samples.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Liu, Siqi
AU  - Liu S
AD  - Key Laboratory for Heavy Metal Pollution Control and Reutilization, School of 
      Environment and Energy, Peking University Shenzhen Graduate School, Shenzhen, 
      518055, China.
FAU - Junaid, Muhammad
AU  - Junaid M
AD  - Key Laboratory for Heavy Metal Pollution Control and Reutilization, School of 
      Environment and Energy, Peking University Shenzhen Graduate School, Shenzhen, 
      518055, China.
FAU - Zhong, Wei
AU  - Zhong W
AD  - Key Laboratory for Heavy Metal Pollution Control and Reutilization, School of 
      Environment and Energy, Peking University Shenzhen Graduate School, Shenzhen, 
      518055, China.
FAU - Zhu, Youchang
AU  - Zhu Y
AD  - Key Laboratory for Heavy Metal Pollution Control and Reutilization, School of 
      Environment and Energy, Peking University Shenzhen Graduate School, Shenzhen, 
      518055, China.
FAU - Xu, Nan
AU  - Xu N
AD  - Key Laboratory for Heavy Metal Pollution Control and Reutilization, School of 
      Environment and Energy, Peking University Shenzhen Graduate School, Shenzhen, 
      518055, China. Electronic address: xunan@pkusz.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200225
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Caprylates)
RN  - 0 (Drinking Water)
RN  - 0 (Fluorocarbons)
RN  - 0 (Water Pollutants, Chemical)
RN  - 375-22-4 (perfluorobutyric acid)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - SE4TWR0K2C (perfluorobutane)
SB  - IM
MH  - Caprylates
MH  - China
MH  - Chromatography, High Pressure Liquid/methods
MH  - Chromatography, Liquid
MH  - Drinking Water/chemistry
MH  - Fluorocarbons/analysis/*chemistry
MH  - Groundwater/*chemistry
MH  - Mass Spectrometry
MH  - Water Pollutants, Chemical/*analysis
OTO - NOTNLM
OT  - Groundwater
OT  - High resolution mass spectrometry
OT  - Per- and polyfluoroalkyl substances (PFASs)
OT  - Precursors
OT  - Quadrupole orbitrap
COIS- Declaration of competing interest Authors declare no conflict of interest.
EDAT- 2020/03/07 06:00
MHDA- 2020/06/04 06:00
CRDT- 2020/03/07 06:00
PHST- 2019/09/30 00:00 [received]
PHST- 2020/02/10 00:00 [revised]
PHST- 2020/02/21 00:00 [accepted]
PHST- 2020/03/07 06:00 [pubmed]
PHST- 2020/06/04 06:00 [medline]
PHST- 2020/03/07 06:00 [entrez]
AID - S0045-6535(20)30520-8 [pii]
AID - 10.1016/j.chemosphere.2020.126327 [doi]
PST - ppublish
SO  - Chemosphere. 2020 Jul;251:126327. doi: 10.1016/j.chemosphere.2020.126327. Epub 
      2020 Feb 25.