PMID- 32143431
OWN - NLM
STAT- MEDLINE
DCOM- 20201105
LR  - 20201105
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 56
IP  - 3
DP  - 2020 Mar 4
TI  - Immunoglobulin E (IgE)-Mediated Food Allergy in Children: Epidemiology, 
      Pathogenesis, Diagnosis, Prevention, and Management.
LID - 10.3390/medicina56030111 [doi]
LID - 111
AB  - A food allergy is an immunoglobulin E (IgE)-mediated hypersensitive reaction to 
      food, which consists in the appearance of allergic symptoms; it can vary from 
      common urticaria to even fatal anaphylaxis. The prevalence of food allergies has 
      been increasing in the past twenty years and it represents a major public health 
      problem in industrialized countries. The mechanism that leads to food allergies 
      is the lack of immunologic and clinical tolerance to food allergens. The 
      diagnosis of IgE-mediated food allergies is based on the combined use of a 
      detailed medical history, in-vivo, and in-vitro research of specific IgE, the 
      elimination diet, and the double-blind placebo-controlled food challenge. The 
      only currently available treatment for allergies is the strict elimination diet. 
      This type of attitude, which we could define as "passive", does not overcome the 
      risk of accidental reactions due to involuntary intake of the culprit food. For 
      food allergy management, an "active" approach is urgently needed, such as 
      specific allergen immunotherapy, which is currently under development and only 
      used for research purposes. This article aims to give an updated review of 
      IgE-mediated food allergies in pediatric populations in terms of epidemiology, 
      pathogenesis, prevention, diagnosis, and management.
FAU - Barni, Simona
AU  - Barni S
AUID- ORCID: 0000-0001-5598-2740
AD  - Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, 
      50139 Florence, Italy.
FAU - Liccioli, Giulia
AU  - Liccioli G
AD  - Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, 
      50139 Florence, Italy.
FAU - Sarti, Lucrezia
AU  - Sarti L
AD  - Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, 
      50139 Florence, Italy.
FAU - Giovannini, Mattia
AU  - Giovannini M
AD  - Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, 
      50139 Florence, Italy.
FAU - Novembre, Elio
AU  - Novembre E
AD  - Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, 
      50139 Florence, Italy.
FAU - Mori, Francesca
AU  - Mori F
AD  - Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, 
      50139 Florence, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200304
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Desensitization, Immunologic
MH  - *Food Hypersensitivity/diagnosis/epidemiology/prevention & control/therapy
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Incidence
MH  - Infant
MH  - Prevalence
PMC - PMC7142605
OTO - NOTNLM
OT  - children
OT  - diagnosis
OT  - epidemiology
OT  - food allergy management
OT  - pathogenesis
OT  - prevention
COIS- The authors declare no conflict of interest.
EDAT- 2020/03/08 06:00
MHDA- 2020/11/06 06:00
PMCR- 2020/03/04
CRDT- 2020/03/08 06:00
PHST- 2020/01/28 00:00 [received]
PHST- 2020/02/25 00:00 [revised]
PHST- 2020/02/28 00:00 [accepted]
PHST- 2020/03/08 06:00 [entrez]
PHST- 2020/03/08 06:00 [pubmed]
PHST- 2020/11/06 06:00 [medline]
PHST- 2020/03/04 00:00 [pmc-release]
AID - medicina56030111 [pii]
AID - medicina-56-00111 [pii]
AID - 10.3390/medicina56030111 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2020 Mar 4;56(3):111. doi: 10.3390/medicina56030111.