PMID- 32144945
OWN - NLM
STAT- MEDLINE
DCOM- 20210525
LR  - 20210525
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 43
IP  - 6
DP  - 2020 Jun
TI  - Prevention of sudden cardiac death in hypertrophic cardiomyopathy: Risk 
      assessment using left atrial diameter predicted from left atrial volume.
PG  - 581-586
LID - 10.1002/clc.23351 [doi]
AB  - BACKGROUND: Left atrial diameter (LAd) is included in the European Society for 
      Cardiology's (ESC) risk model for assessment of sudden cardiac death (SCD) risk 
      in hypertrophic cardiomyopathy (HCM), but the recommended measure of LA size is 
      left atrial volume (LAv). HYPOTHESIS: We hypothesized that LAv could be used 
      instead of LAd in the HCM risk-SCD model. We aimed to determine the relation 
      between LAd and LAv and to assess the impact of using LAv instead of LAd. 
      METHODS: Echocardiographic measurements of anteroposterior LAd in the parasternal 
      long-axis window and LAv from Simpson's biplane method of disks were used. The 
      5-year risk of SCD by measured LAd and by LAd predicted from LAv were estimated 
      using the ESC risk-SCD model. RESULTS: In 205 HCM patients (age 56 +/- 14 years, 
      62% male), the relation between LAd and LAv was linear. Median 5-year risk of SCD 
      was 2.4% (interquartile range [IQR]: 1.6; 3.8) using measured LAd and 2.4% (IQR: 
      1.6; 3.7) using predicted LAd. The correlation between the SCD risk assessed by 
      measured vs predicted LAd was excellent (r(2) = 0.96). Use of predicted LAd 
      resulted in four patients (2%) being recategorized between the moderate and 
      high-risk categories. CONCLUSIONS: The relation between LAd and LAv was linear 
      with good agreement. On a population level, the correlation between the risk of 
      SCD using measured LAd or LAd predicted from LAv was excellent. On a patient 
      level, using LAd predicted from LAv resulted in the vast majority remaining in 
      the same risk category; however, for a minority of patients, it changed the 
      recommendation.
CI  - (c) 2020 The Authors. Clinical Cardiology published by Wiley Periodicals, Inc.
FAU - Mills, Helen
AU  - Mills H
AUID- ORCID: 0000-0002-3011-0740
AD  - The Unit for Inherited Cardiac Diseases, Department of Cardiology, Copenhagen 
      University Hospital, Rigshospitalet, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Espersen, Kiri
AU  - Espersen K
AD  - The Unit for Inherited Cardiac Diseases, Department of Cardiology, Copenhagen 
      University Hospital, Rigshospitalet, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Jurlander, Rebecca
AU  - Jurlander R
AD  - The Unit for Inherited Cardiac Diseases, Department of Cardiology, Copenhagen 
      University Hospital, Rigshospitalet, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Iversen, Kasper
AU  - Iversen K
AD  - Department of Cardiology, Copenhagen University Hospital, Herlev Hospital, 
      University of Copenhagen, Copenhagen, Denmark.
FAU - Bundgaard, Henning
AU  - Bundgaard H
AD  - The Unit for Inherited Cardiac Diseases, Department of Cardiology, Copenhagen 
      University Hospital, Rigshospitalet, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Raja, Anna Axelsson
AU  - Raja AA
AD  - The Unit for Inherited Cardiac Diseases, Department of Cardiology, Copenhagen 
      University Hospital, Rigshospitalet, University of Copenhagen, Copenhagen, 
      Denmark.
AD  - Department of Cardiology, Copenhagen University Hospital, Herlev Hospital, 
      University of Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20200307
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
SB  - IM
MH  - Cardiac Volume/*physiology
MH  - Cardiomyopathy, Hypertrophic/*complications/diagnosis/physiopathology
MH  - Death, Sudden, Cardiac/epidemiology/etiology/*prevention & control
MH  - Denmark/epidemiology
MH  - Echocardiography/*methods
MH  - Female
MH  - Heart Atria/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment/*methods
MH  - Survival Rate
PMC - PMC7298985
OTO - NOTNLM
OT  - echocardiography
OT  - implantable cardioverter-defibrillator
OT  - risk model
OT  - risk prediction
COIS- The authors declare no potential conflict of interest.
EDAT- 2020/03/08 06:00
MHDA- 2021/05/26 06:00
PMCR- 2020/03/07
CRDT- 2020/03/08 06:00
PHST- 2019/07/18 00:00 [received]
PHST- 2020/02/11 00:00 [accepted]
PHST- 2020/03/08 06:00 [pubmed]
PHST- 2021/05/26 06:00 [medline]
PHST- 2020/03/08 06:00 [entrez]
PHST- 2020/03/07 00:00 [pmc-release]
AID - CLC23351 [pii]
AID - 10.1002/clc.23351 [doi]
PST - ppublish
SO  - Clin Cardiol. 2020 Jun;43(6):581-586. doi: 10.1002/clc.23351. Epub 2020 Mar 7.