PMID- 32146630
OWN - NLM
STAT- MEDLINE
DCOM- 20210201
LR  - 20210201
IS  - 1573-8221 (Electronic)
IS  - 0007-4888 (Linking)
VI  - 168
IP  - 4
DP  - 2020 Feb
TI  - Plasma Cytokines Profile in Patients with Parkinson's Disease Associated with 
      Mutations in GBA Gene.
PG  - 423-426
LID - 10.1007/s10517-020-04723-x [doi]
AB  - Plasma cytokine concentration in patients with Parkinson's disease and mutation 
      in GBA gene, in patients with sporadic Parkinson's disease, and in healthy 
      volunteers were measured by ELISA and multiplex analysis. In patients with 
      Parkinson's disease and mutation in GBA gene, elevated plasma concentrations of 
      IL-1beta and TNFalpha were revealed by ELISA in comparison with both controls and 
      patients with sporadic form of Parkinson's disease. Multiplex analysis revealed 
      enhanced secretion of IL-1beta, IL-2, IFNgamma and reduced plasma levels of monocyte 
      chemoattractant protein-1 (MCP-1) in patients with Parkinson's disease and 
      mutation in GBA gene (in comparison with other groups) and increased plasma 
      levels of IL-13 (only in comparison with the healthy volunteers). Our results 
      support the hypothesis that the concentrations of inflammatory mediators are 
      increased in patients with Parkinson's disease and mutation in GBA gene.
FAU - Miliukhina, I V
AU  - Miliukhina IV
AD  - Institute of Experimental Medicine, St. Petersburg, Russia. 
      milyukhinaiv@yandex.ru.
AD  - Ministry of Health of Russian Federation, I. P. Pavlov First St. Petersburg State 
      Medical University, St. Petersburg, Russia. milyukhinaiv@yandex.ru.
AD  - B. P. Konstantinov St. Petersburg Nuclear Physics Institute, National Research 
      Center Kurchatov Institute, Gatchina, Leningrad region, Russia. 
      milyukhinaiv@yandex.ru.
FAU - Usenko, T S
AU  - Usenko TS
AD  - Ministry of Health of Russian Federation, I. P. Pavlov First St. Petersburg State 
      Medical University, St. Petersburg, Russia.
AD  - B. P. Konstantinov St. Petersburg Nuclear Physics Institute, National Research 
      Center Kurchatov Institute, Gatchina, Leningrad region, Russia.
FAU - Senkevich, K A
AU  - Senkevich KA
AD  - Institute of Experimental Medicine, St. Petersburg, Russia.
AD  - Ministry of Health of Russian Federation, I. P. Pavlov First St. Petersburg State 
      Medical University, St. Petersburg, Russia.
AD  - B. P. Konstantinov St. Petersburg Nuclear Physics Institute, National Research 
      Center Kurchatov Institute, Gatchina, Leningrad region, Russia.
FAU - Nikolaev, M A
AU  - Nikolaev MA
AD  - Ministry of Health of Russian Federation, I. P. Pavlov First St. Petersburg State 
      Medical University, St. Petersburg, Russia.
AD  - B. P. Konstantinov St. Petersburg Nuclear Physics Institute, National Research 
      Center Kurchatov Institute, Gatchina, Leningrad region, Russia.
FAU - Timofeeva, A A
AU  - Timofeeva AA
AD  - Ministry of Health of Russian Federation, I. P. Pavlov First St. Petersburg State 
      Medical University, St. Petersburg, Russia.
FAU - Agapova, E A
AU  - Agapova EA
AD  - B. P. Konstantinov St. Petersburg Nuclear Physics Institute, National Research 
      Center Kurchatov Institute, Gatchina, Leningrad region, Russia.
FAU - Semenov, A V
AU  - Semenov AV
AD  - Ministry of Health of Russian Federation, I. P. Pavlov First St. Petersburg State 
      Medical University, St. Petersburg, Russia.
AD  - Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. 
      Petersburg, Russia.
FAU - Lubimova, N E
AU  - Lubimova NE
AD  - Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. 
      Petersburg, Russia.
FAU - Totolyan, A A
AU  - Totolyan AA
AD  - Ministry of Health of Russian Federation, I. P. Pavlov First St. Petersburg State 
      Medical University, St. Petersburg, Russia.
AD  - Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. 
      Petersburg, Russia.
FAU - Pchelina, S N
AU  - Pchelina SN
AD  - Institute of Experimental Medicine, St. Petersburg, Russia.
AD  - Ministry of Health of Russian Federation, I. P. Pavlov First St. Petersburg State 
      Medical University, St. Petersburg, Russia.
AD  - B. P. Konstantinov St. Petersburg Nuclear Physics Institute, National Research 
      Center Kurchatov Institute, Gatchina, Leningrad region, Russia.
LA  - eng
PT  - Journal Article
DEP - 20200307
PL  - United States
TA  - Bull Exp Biol Med
JT  - Bulletin of experimental biology and medicine
JID - 0372557
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IFNG protein, human)
RN  - 0 (IL1B protein, human)
RN  - 0 (IL2 protein, human)
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-2)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 3.2.1.45 (GBA protein, human)
RN  - EC 3.2.1.45 (Glucosylceramidase)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood/genetics/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Gene Expression
MH  - Glucosylceramidase/blood/*genetics/immunology
MH  - Humans
MH  - Inflammation
MH  - Interferon-gamma/blood/genetics/immunology
MH  - Interleukin-13/blood/genetics/immunology
MH  - Interleukin-1beta/blood/genetics/immunology
MH  - Interleukin-2/blood/genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - *Mutation
MH  - Parkinson Disease/blood/*genetics/immunology/pathology
MH  - Tumor Necrosis Factor-alpha/blood/genetics/immunology
OTO - NOTNLM
OT  - ELISA and multiplex assays
OT  - GBA mutation
OT  - Parkinson's disease
OT  - cytokines
OT  - neuroinflammation
EDAT- 2020/03/09 06:00
MHDA- 2021/02/02 06:00
CRDT- 2020/03/09 06:00
PHST- 2019/04/02 00:00 [received]
PHST- 2020/03/09 06:00 [pubmed]
PHST- 2021/02/02 06:00 [medline]
PHST- 2020/03/09 06:00 [entrez]
AID - 10.1007/s10517-020-04723-x [pii]
AID - 10.1007/s10517-020-04723-x [doi]
PST - ppublish
SO  - Bull Exp Biol Med. 2020 Feb;168(4):423-426. doi: 10.1007/s10517-020-04723-x. Epub 
      2020 Mar 7.