PMID- 32146710
OWN - NLM
STAT- MEDLINE
DCOM- 20210913
LR  - 20210913
IS  - 1936-0568 (Electronic)
IS  - 1936-055X (Print)
IS  - 1936-055X (Linking)
VI  - 14
IP  - 4
DP  - 2020 Dec
TI  - Prevalence and Detection of Sexually Transmitted Cases of Laryngeal Carcinoma.
PG  - 909-914
LID - 10.1007/s12105-020-01150-2 [doi]
AB  - INTRODUCTION: Human papillomavirus (HPV) is among the reported etiologies of 
      laryngeal squamous cell carcinoma (LSCC). Understanding the impact of HPV on LSCC 
      may help reduce its incidence. This study investigates the association between 
      HPV and LSCC as well as the roles for different immunohistochemical stains in HPV 
      detection. METHODS: A total of fifty-two formalin-fixed, paraffin-embedded tissue 
      samples of LSCC, diagnosed between 2005 and 2015, were obtained from the archives 
      of the Pathology Department. The samples were stained and processed to evaluate 
      the relationship of HPV to LSCC. RESULTS: Patients had a mean age of 
      65.02 +/- 14.341 years. By polymerase chain reaction (PCR), high-risk strains of 
      HPV were detected in 15.4% of tissue samples. HPV-16 was found in 75% of the 
      positive samples for an overall prevalence of 13.5%. P16 immunostaining was 
      positive in 15.4% of cases while cyclin B and cyclin E were positive in 65.4% and 
      76.9%, respectively. Over half of the cases were histologically graded as 
      moderately-differentiated, 28.8% as well-differentiated, and 15.4% as 
      poorly-differentiated. DISCUSSION: The prevalence of HPV-positive LSCC was lower 
      than previously stated in the literature. HPV-16 was the most commonly detected 
      subtype, in concordance with the findings of multiple other studies. HPV-positive 
      LSCC trended with higher histologic grade. P16 and cyclin E immunohistochemical 
      stains were of limited use in identifying HPV in LSCC. In contrast, cyclin B had 
      a high sensitivity which could be used to rule out HPV in LSCC.
FAU - Al-Qudah, Mohammad Abdulhameed
AU  - Al-Qudah MA
AUID- ORCID: 0000-0001-6877-1184
AD  - Department of Pathology and Microbiology, Faculty of Medicine, Jordan University 
      of Science and Technology, Irbid, 22110, Jordan. m.alqudah12@just.edu.jo.
FAU - Al-Shaikh, Ala'a Fuad
AU  - Al-Shaikh AF
AD  - Ministry of Health, Amman, 11118, Jordan.
FAU - Haddad, Husam Kamel
AU  - Haddad HK
AD  - Department of Pathology and Microbiology, Faculty of Medicine, Jordan University 
      of Science and Technology, Irbid, 22110, Jordan.
FAU - Elhassan, Mohammad Abdelatif
AU  - Elhassan MA
AD  - Department of Pathology and Microbiology, Faculty of Medicine, Jordan University 
      of Science and Technology, Irbid, 22110, Jordan.
FAU - Elhassan, Osman Basheir
AU  - Elhassan OB
AD  - Department of Pathology and Microbiology, Faculty of Medicine, Jordan University 
      of Science and Technology, Irbid, 22110, Jordan.
FAU - Dababneh, Melad Nabeel
AU  - Dababneh MN
AD  - Department of Pathology and Microbiology, Faculty of Medicine, Jordan University 
      of Science and Technology, Irbid, 22110, Jordan.
FAU - Zaitoun, Anas Wasef
AU  - Zaitoun AW
AD  - Jordan University of Science and Technology, Irbid, 22110, Jordan.
FAU - Al Ghamdi, Nawwaf Saleh
AU  - Al Ghamdi NS
AD  - Jordan University of Science and Technology, Irbid, 22110, Jordan.
FAU - Al-Najjar, Bara'a Yousef
AU  - Al-Najjar BY
AD  - Jordan University of Science and Technology, Irbid, 22110, Jordan.
LA  - eng
GR  - 20150359/Jordan University of Science and Technology - Deanship of Research/
PT  - Journal Article
DEP - 20200307
PL  - United States
TA  - Head Neck Pathol
JT  - Head and neck pathology
JID - 101304010
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/epidemiology/*virology
MH  - Male
MH  - Middle Aged
MH  - Papillomaviridae
MH  - Papillomavirus Infections/*diagnosis/*epidemiology
MH  - Prevalence
MH  - Sexually Transmitted Diseases, Viral/*diagnosis/epidemiology
MH  - Squamous Cell Carcinoma of Head and Neck/diagnosis/epidemiology/*virology
PMC - PMC7669925
OTO - NOTNLM
OT  - Cyclin B
OT  - Cyclin E
OT  - Cyclin-dependent kinase inhibitor p16
OT  - Human papilloma virus
OT  - Laryngeal squamous cell carcinoma
OT  - PCR
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/03/09 06:00
MHDA- 2021/09/14 06:00
PMCR- 2021/03/07
CRDT- 2020/03/09 06:00
PHST- 2020/01/03 00:00 [received]
PHST- 2020/02/28 00:00 [accepted]
PHST- 2020/02/15 00:00 [revised]
PHST- 2020/03/09 06:00 [pubmed]
PHST- 2021/09/14 06:00 [medline]
PHST- 2020/03/09 06:00 [entrez]
PHST- 2021/03/07 00:00 [pmc-release]
AID - 10.1007/s12105-020-01150-2 [pii]
AID - 1150 [pii]
AID - 10.1007/s12105-020-01150-2 [doi]
PST - ppublish
SO  - Head Neck Pathol. 2020 Dec;14(4):909-914. doi: 10.1007/s12105-020-01150-2. Epub 
      2020 Mar 7.